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NFE2L3 NFE2 like bZIP transcription factor 3 [ Homo sapiens (human) ]

Gene ID: 9603, updated on 31-Mar-2024

Summary

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Official Symbol
NFE2L3provided by HGNC
Official Full Name
NFE2 like bZIP transcription factor 3provided by HGNC
Primary source
HGNC:HGNC:7783
See related
Ensembl:ENSG00000050344 MIM:604135; AllianceGenome:HGNC:7783
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NRF3
Summary
This gene encodes a member of the cap 'n' collar basic-region leucine zipper family of transcription factors. The encoded protein heterodimerizes with small musculoaponeurotic fibrosarcoma factors to bind antioxidant response elements in target genes. This protein is a membrane bound glycoprotein that is targeted to the endoplasmic reticulum and the nuclear envelope. Pseudogenes of this gene are found on chromosomes 16, 17, and 18. [provided by RefSeq, Mar 2009]
Expression
Broad expression in placenta (RPKM 30.4), appendix (RPKM 7.6) and 16 other tissues See more
Orthologs
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Genomic context

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Location:
7p15.2
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (26152198..26187137)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (26287764..26322815)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (26191818..26226757)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375199 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18027 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18028 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18029 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25774 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25775 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25776 Neighboring gene microRNA 148a Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr7:26050032-26050705 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25777 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:26140958-26141128 Neighboring gene uncharacterized LOC105375198 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25778 Neighboring gene MPRA-validated peak6446 silencer Neighboring gene MPRA-validated peak6447 silencer Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:26187424-26188096 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr7:26188097-26188769 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:26191778-26192572 Neighboring gene OCT4-H3K27ac hESC enhancer GRCh37_chr7:26192573-26193366 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25780 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25781 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:26197976-26198476 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:26198477-26198977 Neighboring gene Sharpr-MPRA regulatory region 12991 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25782 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25783 Neighboring gene Sharpr-MPRA regulatory region 4449 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25784 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25785 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:26227891-26228415 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:26238808-26239781 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:26239782-26240754 Neighboring gene heterogeneous nuclear ribonucleoprotein A2/B1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18035 Neighboring gene chromobox 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. NFE2L3 as a Potential Functional Gene Regulating Immune Microenvironment in Human Kidney Cancer. Zhang Q, et al. Biomed Res Int, 2022. PMID 36337840, Free PMC Article
  2. NFE2L3 promotes tumor progression and predicts a poor prognosis of bladder cancer. Qian J, et al. Carcinogenesis, 2022 Jun 4. PMID 35022660
  3. Elevated expression of NFE2L3 promotes the development of gastric cancer through epithelial-mesenchymal transformation. Wang X, et al. Bioengineered, 2021 Dec. PMID 34783304, Free PMC Article
  4. NFE2L3 Inhibition Induces Cell Cycle Arrest at the G0/G1 Phase in Colorectal Cancer Cells through Downregulating CCND1 and pRb1-ser807/811. Zhang L, et al. Dis Markers, 2019. PMID 31191746, Free PMC Article
  5. Short hairpin RNA-mediated knockdown of nuclear factor erythroid 2-like 3 exhibits tumor-suppressing effects in hepatocellular carcinoma cells. Yu MM, et al. World J Gastroenterol, 2019 Mar 14. PMID 30886504, Free PMC Article

See all (45) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Identification roles of NFE2L3 in digestive system cancers.
    Title: Identification roles of NFE2L3 in digestive system cancers.
  2. Hypomethylation-Mediated Upregulation of NFE2L3 Promotes Malignant Phenotypes of Clear Cell Renal Cell Carcinoma Cells.
    Title: Hypomethylation-Mediated Upregulation of NFE2L3 Promotes Malignant Phenotypes of Clear Cell Renal Cell Carcinoma Cells.
  3. NRF3 suppresses squamous carcinogenesis, involving the unfolded protein response regulator HSPA5.
    Title: NRF3 suppresses squamous carcinogenesis, involving the unfolded protein response regulator HSPA5.
  4. Transcription factor NFE2L3 promotes the proliferation of esophageal squamous cell carcinoma cells and causes radiotherapy resistance by regulating IL-6.
    Title: Transcription factor NFE2L3 promotes the proliferation of esophageal squamous cell carcinoma cells and causes radiotherapy resistance by regulating IL-6.
  5. NFE2L3 as a Potential Functional Gene Regulating Immune Microenvironment in Human Kidney Cancer.
    Title: NFE2L3 as a Potential Functional Gene Regulating Immune Microenvironment in Human Kidney Cancer.
  6. NFE2L3 promotes tumor progression and predicts a poor prognosis of bladder cancer.
    Title: NFE2L3 promotes tumor progression and predicts a poor prognosis of bladder cancer.
  7. Elevated expression of NFE2L3 promotes the development of gastric cancer through epithelial-mesenchymal transformation.
    Title: Elevated expression of NFE2L3 promotes the development of gastric cancer through epithelial-mesenchymal transformation.
  8. NFE2L3 Controls Colon Cancer Cell Growth through Regulation of DUX4, a CDK1 Inhibitor.
    Title: NFE2L3 Controls Colon Cancer Cell Growth through Regulation of DUX4, a CDK1 Inhibitor.
  9. NFE2L1 and NFE2L3 Complementarily Maintain Basal Proteasome Activity in Cancer Cells through CPEB3-Mediated Translational Repression.
    Title: NFE2L1 and NFE2L3 Complementarily Maintain Basal Proteasome Activity in Cancer Cells through CPEB3-Mediated Translational Repression.
  10. NRF3-POMP-20S Proteasome Assembly Axis Promotes Cancer Development via Ubiquitin-Independent Proteolysis of p53 and Retinoblastoma Protein.
    Title: NRF3-POMP-20S Proteasome Assembly Axis Promotes Cancer Development via Ubiquitin-Independent Proteolysis of p53 and Retinoblastoma Protein.
Submit: New GeneRIF Correction See all GeneRIFs (26)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry.
EBI GWAS Catalog
Common variants at 1p36 are associated with superior frontal gyrus volume.
EBI GWAS Catalog
Genome-wide association study of peripheral neuropathy with D-drug-containing regimens in AIDS Clinical Trials Group protocol 384.
EBI GWAS Catalog
Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution.
EBI GWAS Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity TAS
Traceable Author Statement
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
  
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in integrated stress response signaling NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in transcription by RNA polymerase II TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of RNA polymerase II transcription regulator complex IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of chromatin ISA
Inferred from Sequence Alignment
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
nuclear factor erythroid 2-related factor 3
Names
NF-E2-related factor 3
NFE2-related factor 3
nuclear factor, erythroid 2 like 3
nuclear factor, erythroid derived 2, like 3
nuclear factor-erythroid 2 p45-related factor 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004289.7 → NP_004280.5  nuclear factor erythroid 2-related factor 3

    See identical proteins and their annotated locations for NP_004280.5

    Status: REVIEWED

    Source sequence(s)
    AA603252, AC004520, AF134891, BC056142, BX396198
    Consensus CDS
    CCDS5396.1
    UniProtKB/Swiss-Prot
    Q6NUS0, Q7Z498, Q86UJ4, Q86VR5, Q9UQA4, Q9Y4A8
    UniProtKB/TrEMBL
    A4D178
    Related
    ENSP00000056233.3, ENST00000056233.4
    Conserved Domains (1) summary
    cd14720
    Location:575 → 642
    bZIP_NFE2-like; Basic leucine zipper (bZIP) domain of Nuclear Factor, Erythroid-derived 2 (NFE2) and similar proteins: a DNA-binding and dimerization domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    26152198..26187137
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    26287764..26322815
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Y4A8.1 GenPept UniProtKB/Swiss-Prot:Q9Y4A8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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