WTAP WT1 associated protein [Homo sapiens (human)] - Gene

Summary

Official Symbol: WTAPprovided by HGNC
Official Full Name: WT1 associated proteinprovided by HGNC
Primary source: HGNC:HGNC:16846
See related: Ensembl:ENSG00000146457 MIM:605442; AllianceGenome:HGNC:16846
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: Mum2
Summary: The Wilms tumor suppressor gene WT1 appears to play a role in both transcriptional and posttranscriptional regulation of certain cellular genes. This gene encodes a WT1-associating protein, which is a ubiquitously expressed nuclear protein. Like WT1 protein, this protein is localized throughout the nucleoplasm as well as in speckles and partially colocalizes with splicing factors. Alternative splicing of this gene results in several transcript variants encoding three different isoforms. [provided by RefSeq, Jul 2012]
Expression: Ubiquitous expression in bone marrow (RPKM 44.8), lymph node (RPKM 20.4) and 25 other tissues See more
Orthologs: mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 6q25.3

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	6	NC_000006.12 (159726693..159756319)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	6	NC_060930.1 (160967457..161001943)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	6	NC_000006.11 (160148149..160177351)

Chromosome 6 - NC_000006.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

WTAP regulates the production of reactive oxygen species, promotes malignant progression, and is closely related to the tumor microenvironment in glioblastoma.
Title: WTAP regulates the production of reactive oxygen species, promotes malignant progression, and is closely related to the tumor microenvironment in glioblastoma.
WTAP Mediated N6-methyladenosine RNA Modification of ELF3 Drives Cellular Senescence by Upregulating IRF8.
Title: WTAP Mediated N6-methyladenosine RNA Modification of ELF3 Drives Cellular Senescence by Upregulating IRF8.
Regulation of ULK1 by WTAP/IGF2BP3 axis enhances mitophagy and progression in epithelial ovarian cancer.
Title: Regulation of ULK1 by WTAP/IGF2BP3 axis enhances mitophagy and progression in epithelial ovarian cancer.
WTAP-mediated m[6]A modification of FRZB triggers the inflammatory response via the Wnt signaling pathway in osteoarthritis.
Title: WTAP-mediated m(6)A modification of FRZB triggers the inflammatory response via the Wnt signaling pathway in osteoarthritis.
[m[6]A methylase WTAP participates in renal ischemia-reperfusion injury by regulating FOXO1 expression].
Title: [m(6)A methylase WTAP participates in renal ischemia-reperfusion injury by regulating FOXO1 expression].
WTAP Mediated the N6-methyladenosine Modification of PDK4 to Regulate the Malignant Behaviors of Colorectal Cancer Cells In Vitro and In Vivo.
Title: WTAP Mediated the N6-methyladenosine Modification of PDK4 to Regulate the Malignant Behaviors of Colorectal Cancer Cells In Vitro and In Vivo.
A cleaved METTL3 potentiates the METTL3-WTAP interaction and breast cancer progression.
Title: A cleaved METTL3 potentiates the METTL3-WTAP interaction and breast cancer progression.
N6-methyladenosine (m6A) methyltransferase WTAP-mediated miR-92b-5p accelerates osteoarthritis progression.
Title: N6-methyladenosine (m6A) methyltransferase WTAP-mediated miR-92b-5p accelerates osteoarthritis progression.
PRMT1 methylation of WTAP promotes multiple myeloma tumorigenesis by activating oxidative phosphorylation via m6A modification of NDUFS6.
Title: PRMT1 methylation of WTAP promotes multiple myeloma tumorigenesis by activating oxidative phosphorylation via m6A modification of NDUFS6.
WTAP activates MAPK signaling through m6A methylation in VEGFA mRNA-mediated by YTHDC1 to promote colorectal cancer development.
Title: WTAP activates MAPK signaling through m6A methylation in VEGFA mRNA-mediated by YTHDC1 to promote colorectal cancer development.

Submit: New GeneRIF Correction See all GeneRIFs (69)

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Variants in TF and HFE explain approximately 40% of genetic variation in serum-transferrin levels. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

SHGC-56705 (e-PCR)
- UniSTS:67334

SHGC-56803 (e-PCR)
- UniSTS:63323

MARC_17739-17740:1031760457:1 (e-PCR)
- UniSTS:268391

RH45346 (e-PCR)
- UniSTS:75903

RH45351 (e-PCR)
- UniSTS:79551

RH25332 (e-PCR)
- UniSTS:84682

RH45141 (e-PCR)
- UniSTS:48858

Wtap (e-PCR), detects polymorphism
- UniSTS:498921

D6S1433 (e-PCR)
- UniSTS:66286

RH40826 (e-PCR)
- UniSTS:92153

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in RNA splicing	IEA Inferred from Electronic Annotation more info
involved_in cell cycle	IEA Inferred from Electronic Annotation more info
involved_in mRNA modification	IBA Inferred from Biological aspect of Ancestor more info
involved_in mRNA modification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mRNA modification	NAS Non-traceable Author Statement more info	PubMed
involved_in mRNA processing	IEA Inferred from Electronic Annotation more info
involved_in regulation of alternative mRNA splicing, via spliceosome	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of alternative mRNA splicing, via spliceosome	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of RNA N6-methyladenosine methyltransferase complex	IDA Inferred from Direct Assay more info	PubMed
part_of RNA N6-methyladenosine methyltransferase complex	IPI Inferred from Physical Interaction more info	PubMed
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in nuclear membrane	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear speck	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	NAS Non-traceable Author Statement more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: pre-mRNA-splicing regulator WTAP

Names: PNAS-132; Wilms tumor 1 associated protein; Wilms' tumour 1-associating protein; female-lethal(2)D homolog; hFL(2)D; putative pre-mRNA splicing regulator female-lethal(2D); wilms tumor 1-associating protein

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001270531.2 → NP_001257460.1 pre-mRNA-splicing regulator WTAP isoform 1

See identical proteins and their annotated locations for NP_001257460.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1 and 4 both encode the same isoform (1).

Source sequence(s)

AF374416, BC069192, BG702882, BX387163

Consensus CDS

CCDS5266.1

UniProtKB/Swiss-Prot

Q15007, Q5TCL8, Q5TCL9, Q96T28, Q9BYJ7, Q9H4E2

UniProtKB/TrEMBL

A8K489

Related

ENSP00000479438.1, ENST00000621533.5

Conserved Domains (1) summary

pfam17098
Location:68 → 222

Wtap; WTAP/Mum2p family
NM_001270532.2 → NP_001257461.1 pre-mRNA-splicing regulator WTAP isoform 3

See identical proteins and their annotated locations for NP_001257461.1

Status: REVIEWED

Description

Transcript Variant: This variant (5) has an alternate 3' end sequence compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus compared to isoform 1. Variants 5 and 6 both encode the same isoform (3).

Source sequence(s)

AA706250, BE906617, CN284477, D14661

Consensus CDS

CCDS75542.1

UniProtKB/TrEMBL

A0A087X1R4

Related

ENSP00000484404.1, ENST00000614346.4

Conserved Domains (1) summary

pfam17098
Location:68 → 150

Wtap; WTAP/Mum2p family
NM_001270533.2 → NP_001257462.1 pre-mRNA-splicing regulator WTAP isoform 3

See identical proteins and their annotated locations for NP_001257462.1

Status: REVIEWED

Description

Transcript Variant: This variant (6) has an alternate 5' and 3' end sequences compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus compared to isoform 1. Variants 5 and 6 both encode the same isoform (3).

Source sequence(s)

AA706250, BG702882, BQ948913, D14661

Consensus CDS

CCDS75542.1

UniProtKB/TrEMBL

A0A087X1R4

Related

ENSP00000487338.1, ENST00000631126.2

Conserved Domains (1) summary

pfam17098
Location:68 → 150

Wtap; WTAP/Mum2p family
NM_004906.5 → NP_004897.2 pre-mRNA-splicing regulator WTAP isoform 1

See identical proteins and their annotated locations for NP_004897.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Variants 1 and 4 both encode the same isoform (1).

Source sequence(s)

AF374416, BC069192, BE906617

Consensus CDS

CCDS5266.1

UniProtKB/Swiss-Prot

Q15007, Q5TCL8, Q5TCL9, Q96T28, Q9BYJ7, Q9H4E2

UniProtKB/TrEMBL

A8K489

Related

ENSP00000351141.4, ENST00000358372.8

Conserved Domains (1) summary

pfam17098
Location:68 → 222

Wtap; WTAP/Mum2p family
NM_152857.3 → NP_690596.1 pre-mRNA-splicing regulator WTAP isoform 2

See identical proteins and their annotated locations for NP_690596.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) has alternate 5' and 3' end sequences compared to variant 1. Because of the frameshift and immediate translation termination, the resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1. Variants 2 and 3 both encode the same isoform (2).

Source sequence(s)

AA706250, BG702882, D14661

Consensus CDS

CCDS5267.1

UniProtKB/Swiss-Prot

Q15007

Related

ENSP00000336911.4, ENST00000337387.4

Conserved Domains (1) summary

pfam17098
Location:68 → 150

Wtap; WTAP/Mum2p family
NM_152858.3 → NP_690597.1 pre-mRNA-splicing regulator WTAP isoform 2

See identical proteins and their annotated locations for NP_690597.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) has an alternate 3' end sequence compared to variant 1, that causes a frameshift and immediate translation termination. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1. Variants 2 and 3 both encode the same isoform (2).

Source sequence(s)

AA706250, BE906617, D14661, DA561768

Consensus CDS

CCDS5267.1

UniProtKB/Swiss-Prot

Q15007

Related

ENSP00000497840.1, ENST00000650096.1

Conserved Domains (1) summary

pfam17098
Location:68 → 150

Wtap; WTAP/Mum2p family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000006.12 Reference GRCh38.p14 Primary Assembly

Range

159726693..159756319

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017011514.3 → XP_016867003.1 pre-mRNA-splicing regulator WTAP isoform X1

UniProtKB/TrEMBL

A8K489
XM_017011516.3 → XP_016867005.1 pre-mRNA-splicing regulator WTAP isoform X4
XM_047419578.1 → XP_047275534.1 pre-mRNA-splicing regulator WTAP isoform X2

UniProtKB/Swiss-Prot

Q15007, Q5TCL8, Q5TCL9, Q96T28, Q9BYJ7, Q9H4E2
XM_017011515.2 → XP_016867004.1 pre-mRNA-splicing regulator WTAP isoform X3

UniProtKB/TrEMBL

A8K489

Alternate T2T-CHM13v2.0

Genomic

NC_060930.1 Alternate T2T-CHM13v2.0

Range

160967457..161001943

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054356858.1 → XP_054212833.1 pre-mRNA-splicing regulator WTAP isoform X1
XM_054356861.1 → XP_054212836.1 pre-mRNA-splicing regulator WTAP isoform X4
XM_054356859.1 → XP_054212834.1 pre-mRNA-splicing regulator WTAP isoform X2

UniProtKB/Swiss-Prot

Q15007, Q5TCL8, Q5TCL9, Q96T28, Q9BYJ7, Q9H4E2
XM_054356860.1 → XP_054212835.1 pre-mRNA-splicing regulator WTAP isoform X3