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LASVsSgp1 nucleoprotein [ Mammarenavirus lassaense ]

Gene ID: 956584, updated on 18-Aug-2023

Summary

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Gene symbol
LASVsSgp1
Gene description
nucleoprotein
Locus tag
LASVsSgp1
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mammarenavirus lassaense (strain: Josiah)
Lineage
Viruses; Riboviria; Orthornavirae; Negarnaviricota; Polyploviricotina; Ellioviricetes; Bunyavirales; Arenaviridae; Mammarenavirus
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Genomic context

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Location:
segment: S
Sequence:
NC_004296.1 (101..1810)

NC_004296.1Genomic Context describing neighboring genes Neighboring gene glycoprotein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_004296.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Exonuclease domain of the Lassa virus nucleoprotein is critical to avoid RIG-I signaling and to inhibit the innate immune response. Reynard S, et al. J Virol, 2014 Dec. PMID 25253344, Free PMC Article
  2. The exonuclease domain of Lassa virus nucleoprotein is involved in antigen-presenting-cell-mediated NK cell responses. Russier M, et al. J Virol, 2014 Dec. PMID 25253342, Free PMC Article
  3. The role of oligomerization for the biological functions of the arenavirus nucleoprotein. Lennartz F, et al. Arch Virol, 2013 Sep. PMID 23553456
  4. Studies on the binding modes of Lassa nucleoprotein complexed with m7GpppG and dTTP by molecular dynamic simulations and free energy calculations. Li L, et al. J Biomol Struct Dyn, 2013 Mar. PMID 22871039
  5. Structure of the Lassa virus nucleoprotein revealed by X-ray crystallography, small-angle X-ray scattering, and electron microscopy. Brunotte L, et al. J Biol Chem, 2011 Nov 4. PMID 21917929, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These results highlight the key role of nucleoprotein exonuclease domain function in the immune evasion that occurs during Lassa virus infection.
    Title: Exonuclease domain of the Lassa virus nucleoprotein is critical to avoid RIG-I signaling and to inhibit the innate immune response.
  2. Importantly, authors demonstrate for the first time that Lassa virus nucleoprotein is involved in the inhibition of antigen-presenting cell-mediated NK cell responses.
    Title: The exonuclease domain of Lassa virus nucleoprotein is involved in antigen-presenting-cell-mediated NK cell responses.
  3. NP trimerization is essential for transcription and/or replication of the viral genome.
    Title: The role of oligomerization for the biological functions of the arenavirus nucleoprotein.
  4. molecular dynamics (MD) simulations have been carried out to investigate the characters of deoxythymidine triphosphate binding to two forms of nucleoprotein.
    Title: Studies on the binding modes of Lassa nucleoprotein complexed with m7GpppG and dTTP by molecular dynamic simulations and free energy calculations.
  5. Structure of the Lassa virus nucleoprotein revealed by X-ray crystallography, small-angle X-ray scattering, and electron microscopy
    Title: Structure of the Lassa virus nucleoprotein revealed by X-ray crystallography, small-angle X-ray scattering, and electron microscopy.
  6. Residues D389 and G392 of nucleoprotein were critical for Lassa virus viability, while the D389A/G392A and D389T/392A double mutants were severely altered in the ability to suppress interferon in macrophages and dendritic cells.
    Title: Lassa virus nucleoprotein mutants generated by reverse genetics induce a robust type I interferon response in human dendritic cells and macrophages.
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General gene information

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Homology

General protein information

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Preferred Names
nucleoprotein

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004296.1 Reference assembly

    Range
    101..1810
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_694869.1 nucleoprotein [Mammarenavirus lassaense]

    See identical proteins and their annotated locations for NP_694869.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P13699
    UniProtKB/TrEMBL
    A0A097F434, A0A097F435, F1D8L1, Q6GWS1
    Conserved Domains (2) summary
    pfam00843
    Location:4 → 339
    Arena_nucleocap; Arenavirus nucleocapsid N-terminal domain
    pfam17290
    Location:367 → 543
    Arena_ncap_C; Arenavirus nucleocapsid C-terminal domain
Protein Accession Links
GenPept Link UniProtKB Link
AAA46285.1
AAT49003.1
ADY11069.1
ADY11071.1
AEY85212.1
APT69591.1
APT69604.1
APT69608.1
APT69663.1
QST04902.1

Gene LinkOut

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Molecular Biology Databases
Research Materials