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HA hemagglutinin [ Influenza B virus (B/Lee/1940) ]

Gene ID: 956538, updated on 18-Aug-2023

Summary

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Gene symbol
HA
Gene description
hemagglutinin
Locus tag
FLUBVsRNA-4gp1
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Influenza B virus (B/Lee/1940) (strain: B/Lee/40)
Lineage
Viruses; ssRNA viruses; ssRNA negative-strand viruses; Orthomyxoviridae; Influenzavirus B
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Genomic context

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Location:
segment: 4
Sequence:
NC_002207.1 (34..1788)

NC_002207.1Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_002207.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The roles of hemagglutinin Phe-95 in receptor binding and pathogenicity of influenza B virus. Ni F, et al. Virology, 2014 Feb. PMID 24503069, Free PMC Article
  2. Structural basis for the divergent evolution of influenza B virus hemagglutinin. Ni F, et al. Virology, 2013 Nov. PMID 24074573, Free PMC Article
  3. The cytoplasmic tail domain of influenza B virus hemagglutinin is important for its incorporation into virions but is not essential for virus replication in cell culture in the presence of compensatory mutations. Imai M, et al. J Virol, 2012 Nov. PMID 22896616, Free PMC Article
  4. Passage in egg culture is a major cause of apparent positive selection in influenza B hemagglutinin. Gatherer D. J Med Virol, 2010 Jan. PMID 19950248
  5. A point mutation at the C terminus of the cytoplasmic domain of influenza B virus haemagglutinin inhibits syncytium formation. Ujike M, et al. J Gen Virol, 2006 Jun. PMID 16690932

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Hemagglutinin cleavability, acid stability, and temperature dependence optimize influenza B virus for replication in human airways.
    Title: Hemagglutinin Cleavability, Acid Stability, and Temperature Dependence Optimize Influenza B Virus for Replication in Human Airways.
  2. Although random reassortment event may generate unique reassortants, detailed phylogenetic classification of gene segments showed possible genetic linkage between PA and NA genes in B/Phuket/3073/2013-like viruses, which requires further investigation. Understanding on reassortment patterns in influenza B evolution may contribute to future vaccine design.
    Title: Whole-Genome Phylogenetic Analysis of Influenza B/Phuket/3073/2013-Like Viruses and Unique Reassortants Detected in Malaysia between 2012 and 2014.
  3. Results show that in influenza B viruses genomic segments coding for PB1 and PB2 and hemagglutinin proteins have been maintained in only Victoria and Yamagata lineages.
    Title: Reassortment between influenza B lineages and the emergence of a coadapted PB1-PB2-HA gene complex.
  4. Mutation Phe95-->Tyr in influenza B virus HA enhance receptor binding.
    Title: The roles of hemagglutinin Phe-95 in receptor binding and pathogenicity of influenza B virus.
  5. HAs of diverged influenza B virus strains display much stronger molecular interactions with terminal sialic acid of bound receptors.
    Title: Structural basis for the divergent evolution of influenza B virus hemagglutinin.
  6. These findings indicate that the cytoplasmic tail domain of influenza B virus hemagglutinin is important for efficient incorporation of hemagglutinin into virions and tight lipid raft association.
    Title: The cytoplasmic tail domain of influenza B virus hemagglutinin is important for its incorporation into virions but is not essential for virus replication in cell culture in the presence of compensatory mutations.
  7. Non-synonymous mutations resulting in the loss of the N-glycosylation site at positions 197-199 of hemagglutinin have been positively selected to a far greater degree in egg-cultured strains than in other strains
    Title: Passage in egg culture is a major cause of apparent positive selection in influenza B hemagglutinin.
  8. results demonstrate that Leu at the end portion of the C terminus of the HA-CT (cytoplasmic tail) is not essential for membrane fusion, but that the hydrophobicity of the single amino acid at this position plays an important role in syncytium formation
    Title: A point mutation at the C terminus of the cytoplasmic domain of influenza B virus haemagglutinin inhibits syncytium formation.
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General gene information

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Homology

General protein information

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Preferred Names
hemagglutinin
NP_056660.1
  • glycoprotein

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_002207.1 Reference assembly

    Range
    34..1788
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_056660.1 hemagglutinin [Influenza B virus (B/Lee/1940)]

    See identical proteins and their annotated locations for NP_056660.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P03460
    UniProtKB/TrEMBL
    I0B748, I0B8D7
    Conserved Domains (1) summary
    pfam00509
    Location:18 → 584
    Hemagglutinin; Haemagglutinin
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P03460.1

Gene LinkOut

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Research Materials