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NS1 nonstructural protein 1 [ Influenza A virus (A/Puerto Rico/8/1934(H1N1)) ]

Gene ID: 956533, updated on 5-Jun-2024

Summary

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Gene symbol
NS1
Gene description
nonstructural protein 1
Locus tag
FLUAVs8gp2
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Influenza A virus (A/Puerto Rico/8/1934(H1N1)) (strain: A/Puerto Rico/8/1934, serotype: H1N1)
Lineage
Viruses; ssRNA viruses; ssRNA negative-strand viruses; Orthomyxoviridae; Influenzavirus A
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Genomic context

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Location:
segment: 8
Sequence:
NC_002020.1 (27..719)

NC_002020.1Genomic Context describing neighboring genes Neighboring gene nonstructural protein 2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_002020.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Phosphorylation of Influenza A Virus NS1 at Serine 205 Mediates Its Viral Polymerase-Enhancing Function. Patil A, et al. J Virol, 2021 Feb 24. PMID 33408177, Free PMC Article
  2. Influenza A virus NS1 optimises virus infectivity by enhancing genome packaging in a dsRNA-binding dependent manner. Sha TW, et al. Virol J, 2020 Jul 16. PMID 32677963, Free PMC Article
  3. Structural basis for influenza virus NS1 protein block of mRNA nuclear export. Zhang K, et al. Nat Microbiol, 2019 Oct. PMID 31263181, Free PMC Article
  4. A Novel Role for PDZ-Binding Motif of Influenza A Virus Nonstructural Protein 1 in Regulation of Host Susceptibility to Postinfluenza Bacterial Superinfections. Shepardson K, et al. Viral Immunol, 2019 Apr. PMID 30822217, Free PMC Article
  5. Influenza A virus-derived siRNAs increase in the absence of NS1 yet fail to inhibit virus replication. Tsai K, et al. RNA, 2018 Sep. PMID 29903832, Free PMC Article

See all (67) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Influenza A virus NS1 effector domain is required for PA-X-mediated host shutoff in infected cells.
    Title: Influenza A virus NS1 effector domain is required for PA-X-mediated host shutoff in infected cells.
  2. The circRNA circVAMP3 restricts influenza A virus replication by interfering with NP and NS1 proteins.
    Title: The circRNA circVAMP3 restricts influenza A virus replication by interfering with NP and NS1 proteins.
  3. Nonstructural Protein NS1 of Influenza Virus Disrupts Mitochondrial Dynamics and Enhances Mitophagy via ULK1 and BNIP3.
    Title: Nonstructural Protein NS1 of Influenza Virus Disrupts Mitochondrial Dynamics and Enhances Mitophagy via ULK1 and BNIP3.
  4. RuvB-Like Protein 2 Interacts with the NS1 Protein of Influenza A Virus and Affects Apoptosis That Is Counterbalanced by Type I Interferons.
    Title: RuvB-Like Protein 2 Interacts with the NS1 Protein of Influenza A Virus and Affects Apoptosis That Is Counterbalanced by Type I Interferons.
  5. Influenza A virus NS1 induces degradation of sphingosine 1-phosphate lyase to obstruct the host innate immune response.
    Title: Influenza A virus NS1 induces degradation of sphingosine 1-phosphate lyase to obstruct the host innate immune response.
  6. Influenza a virus NS1 resembles a TRAF3-interacting motif to target the RNA sensing-TRAF3-type I IFN axis and impair antiviral innate immunity.
    Title: Influenza a virus NS1 resembles a TRAF3-interacting motif to target the RNA sensing-TRAF3-type I IFN axis and impair antiviral innate immunity.
  7. Phosphorylation of Influenza A Virus NS1 at Serine 205 Mediates Its Viral Polymerase-Enhancing Function.
    Title: Phosphorylation of Influenza A Virus NS1 at Serine 205 Mediates Its Viral Polymerase-Enhancing Function.
  8. Influenza A virus NS1 optimises virus infectivity by enhancing genome packaging in a dsRNA-binding dependent manner.
    Title: Influenza A virus NS1 optimises virus infectivity by enhancing genome packaging in a dsRNA-binding dependent manner.
  9. Influenza virus NS1- C/EBPbeta gene regulatory complex inhibits RIG-I transcription.
    Title: Influenza virus NS1- C/EBPβ gene regulatory complex inhibits RIG-I transcription.
  10. Differential modulation of innate immune responses in human primary cells by influenza A viruses carrying human or avian NS1 protein has been reported.
    Title: Differential Modulation of Innate Immune Responses in Human Primary Cells by Influenza A Viruses Carrying Human or Avian Nonstructural Protein 1.
Submit: New GeneRIF Correction See all GeneRIFs (65)

Pathways from PubChem

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General gene information

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Homology

General protein information

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Preferred Names
nonstructural protein 1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_002020.1 Reference assembly

    Range
    27..719
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_040984.1 nonstructural protein 1 [Influenza A virus (A/Puerto Rico/8/1934(H1N1))]

    See identical proteins and their annotated locations for NP_040984.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    B4URE2, P03496, Q20N32, Q67267, Q71QT3
    UniProtKB/TrEMBL
    A0A075ETP1, A0A1D8EMU4, A0A343VTR9, A0A3S7GZT7, A4ZNQ3, B4UPB2, B6A767, C7S276, D5F1U6, E5FF42, F0TTA7, F0TTF1, F5CGM8, F5CGN9, F5CGQ0, H8PHK7, H8XZT1, H8XZV5, H8XZW5, I6S507, I6S8B7, I6SGN6, I6SIC0, I6SIT8, I6T2Q4, I6T3J6, I6T525, I6TAB5, I6TAG8, I6TDL1
    Conserved Domains (1) summary
    pfam00600
    Location:1 → 216
    Flu_NS1; Influenza non-structural protein (NS1)
Nucleotide Protein
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Gene LinkOut

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