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gag gag protein [ Simian immunodeficiency virus SIV-mnd 2 ]

Gene ID: 956108, updated on 18-Aug-2023

Summary

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Gene symbol
gag
Gene description
gag protein
Locus tag
Siv2gp1
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Simian immunodeficiency virus SIV-mnd 2 (isolate: SIVmnd-2, nat-host: Mandrillus sphinx)
Lineage
Viruses; Retro-transcribing viruses; Retroviridae; Orthoretrovirinae; Lentivirus; Primate lentivirus group
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Genomic context

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Sequence:
NC_004455.1 (737..2290)

NC_004455.1Genomic Context describing neighboring genes Neighboring gene pol protein Neighboring gene vif protein Neighboring gene vpx protein Neighboring gene vpr protein Neighboring gene tat protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_004455.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cell-mediated anti-Gag immunity in pharmacologically induced functional cure of simian AIDS: a 'bottleneck effect'? Shytaj IL, et al. J Med Primatol, 2015 Oct. PMID 26058990
  2. Contribution of glutamine residues in the helix 4-5 loop to capsid-capsid interactions in simian immunodeficiency virus of macaques. Tipper C, et al. J Virol, 2014 Sep. PMID 24991000, Free PMC Article
  3. Mapping of the self-interaction domains in the simian immunodeficiency virus Gag polyprotein. Rauddi ML, et al. AIDS Res Hum Retroviruses, 2011 Mar. PMID 20969459
  4. Identification and structural characterization of the ALIX-binding late domains of simian immunodeficiency virus SIVmac239 and SIVagmTan-1. Zhai Q, et al. J Virol, 2011 Jan. PMID 20962096, Free PMC Article
  5. Natural infection of wild-born mandrills (Mandrillus sphinx) with two different types of simian immunodeficiency virus. Takehisa J, et al. AIDS Res Hum Retroviruses, 2001 Aug 10. PMID 11522184

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Glutamines 89 and 92 located on the distal face of hexameric capsid contribute to interhexamer interactions.
    Title: Contribution of glutamine residues in the helix 4-5 loop to capsid-capsid interactions in simian immunodeficiency virus of macaques.
  2. The authors identified the region comprising the C-terminal third portion of the capsid and the entire nucleocapsid as the major SIV Gag interacting domain.
    Title: Mapping of the self-interaction domains in the simian immunodeficiency virus Gag polyprotein.
  3. Crystal structures revealed that anchoring tyrosines and nearby hydrophobic residues contact the ALIX V domain, revealing how SIV gag proteins employ a diverse family of late-domain sequences to bind ALIX and promote virus budding.
    Title: Identification and structural characterization of the ALIX-binding late domains of simian immunodeficiency virus SIVmac239 and SIVagmTan-1.
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General gene information

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Homology

General protein information

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Preferred Names
gag protein

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004455.1 Reference assembly

    Range
    737..2290
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_758886.1 gag protein [Simian immunodeficiency virus SIV-mnd 2]

    See identical proteins and their annotated locations for NP_758886.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    Q7ZB20, Q8Q7J5
    Conserved Domains (3) summary
    pfam00540
    Location:2 → 136
    Gag_p17; gag gene protein p17 (matrix protein)
    pfam00098
    Location:418 → 435
    zf-CCHC; Zinc knuckle
    pfam00607
    Location:152 → 366
    Gag_p24; gag gene protein p24 (core nucleocapsid protein)
Nucleotide Protein
Heading Accession and Version

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