CXCL14 C-X-C motif chemokine ligand 14 [Homo sapiens (human)] - Gene

Summary

Official Symbol: CXCL14provided by HGNC
Official Full Name: C-X-C motif chemokine ligand 14provided by HGNC
Primary source: HGNC:HGNC:10640
See related: Ensembl:ENSG00000145824 MIM:604186; AllianceGenome:HGNC:10640
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: KEC; KS1; BMAC; BRAK; NJAC; MIP2G; MIP-2g; SCYB14
Summary: This antimicrobial gene belongs to the cytokine gene family which encode secreted proteins involved in immunoregulatory and inflammatory processes. The protein encoded by this gene is structurally related to the CXC (Cys-X-Cys) subfamily of cytokines. Members of this subfamily are characterized by two cysteines separated by a single amino acid. This cytokine displays chemotactic activity for monocytes but not for lymphocytes, dendritic cells, neutrophils or macrophages. It has been implicated that this cytokine is involved in the homeostasis of monocyte-derived macrophages rather than in inflammation. [provided by RefSeq, Sep 2014]
Expression: Biased expression in skin (RPKM 295.1), kidney (RPKM 161.0) and 13 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 5q31.1

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	5	NC_000005.10 (135570679..135578991, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	5	NC_060929.1 (136097821..136106134, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	5	NC_000005.9 (134906369..134914681, complement)

Chromosome 5 - NC_000005.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Osteosarcoma Cells Secrete CXCL14 That Activates Integrin alpha11beta1 on Fibroblasts to Form a Lung Metastatic Niche.
Title: Osteosarcoma Cells Secrete CXCL14 That Activates Integrin α11β1 on Fibroblasts to Form a Lung Metastatic Niche.
Analysis of the mucosal chemokines CCL28, CXCL14, and CXCL17 in dry eye disease: An in vitro and clinical investigation.
Title: Analysis of the mucosal chemokines CCL28, CXCL14, and CXCL17 in dry eye disease: An in vitro and clinical investigation.
The Chemokine CXCL14 as a Potential Immunotherapeutic Agent for Cancer Therapy.
Title: The Chemokine CXCL14 as a Potential Immunotherapeutic Agent for Cancer Therapy.
CXCL14 as a Key Regulator of Neuronal Development: Insights from Its Receptor and Multi-Omics Analysis.
Title: CXCL14 as a Key Regulator of Neuronal Development: Insights from Its Receptor and Multi-Omics Analysis.
Proinflammatory chemokine CXCL14 activates MAS-related G protein-coupled receptor MRGPRX2 and its putative mouse ortholog MRGPRB2.
Title: Proinflammatory chemokine CXCL14 activates MAS-related G protein-coupled receptor MRGPRX2 and its putative mouse ortholog MRGPRB2.
Data Mining Suggests That CXCL14 Gene Silencing in Colon Cancer Is Due to Promoter Methylation.
Title: Data Mining Suggests That CXCL14 Gene Silencing in Colon Cancer Is Due to Promoter Methylation.
Comprehensive analysis of CXCL14 uncovers its role during liver metastasis in colon cancer.
Title: Comprehensive analysis of CXCL14 uncovers its role during liver metastasis in colon cancer.
CXCL5 and CXCL14, but not CXCL16 as potential biomarkers of colorectal cancer.
Title: CXCL5 and CXCL14, but not CXCL16 as potential biomarkers of colorectal cancer.
Characterization of the bone marrow niche in patients with chronic myeloid leukemia identifies CXCL14 as a new therapeutic option.
Title: Characterization of the bone marrow niche in patients with chronic myeloid leukemia identifies CXCL14 as a new therapeutic option.
CXCL14 promotes metastasis of non-small cell lung cancer through ACKR2-depended signaling pathway.
Title: CXCL14 promotes metastasis of non-small cell lung cancer through ACKR2-depended signaling pathway.

Submit: New GeneRIF Correction See all GeneRIFs (100)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study of smoking behaviours in patients with COPD. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Tat	tat	Microarray analysis indicates HIV-1 Tat-induced upregulation of chemokine (C-X-C motif) ligand 14 (CXCL14) in primary human brain microvascular endothelial cells	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

G59717 (e-PCR)
- UniSTS:137016

CXCL14__2459 (e-PCR)
- UniSTS:280632

A002I14 (e-PCR)
- UniSTS:37714

A005K28 (e-PCR)
- UniSTS:17868

WI-13424 (e-PCR)
- UniSTS:57293

CXCL14 (e-PCR)
- UniSTS:278259

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables chemokine activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell chemotaxis	IEA Inferred from Electronic Annotation more info
involved_in cell-cell signaling	TAS Traceable Author Statement more info	PubMed
involved_in chemotaxis	TAS Traceable Author Statement more info	PubMed
involved_in signal transduction	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	IDA Inferred from Direct Assay more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: C-X-C motif chemokine 14

Names: CXC chemokine in breast and kidney; MIP-2 gamma; bolekine; breast and kidney; chemokine (C-X-C motif) ligand 14; chemokine BRAK; small inducible cytokine subfamily B (Cys-X-Cys), member 14 (BRAK); small-inducible cytokine B14; tumor-suppressing chemokine

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_004887.5 → NP_004878.3 C-X-C motif chemokine 14 precursor

Status: REVIEWED

Source sequence(s)

AC034206

Consensus CDS

CCDS4188.2

UniProtKB/TrEMBL

A0A0C4DGC1

Related

ENSP00000423783.1, ENST00000512158.6

Conserved Domains (1) summary

cl00134
Location:24 → 85

Chemokine; small cytokines, including a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; distinguished from other cytokines by their receptors, which are G-protein coupled receptors; divided into 4 ...