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nanM N-acetylneuraminate mutarotase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 949106, updated on 19-Sep-2024

Summary

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Official Symbol
nanM
Official Full Name
N-acetylneuraminate mutarotase
Primary source
ECOCYC:G7920
Locus tag
b4310
See related
ASAP:ABE-0014132
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK4301; yjhT
Summary
NanM has N-acetylneuraminic acid mutarotase activity and is required for the efficient utilization of N-acetylneuraminic acid (Da Severi, 2008). [More information is available at EcoGene: EG12562]. N-acetylneuraminate mutarotase supports the efficient use of -N-acetylneuraminate (-Neu5Ac) as the sole source of carbon. [More information is available at EcoCyc: G7920].
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Genomic context

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Sequence:
NC_000913.3 (4537659..4538765, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene protein YthB Neighboring gene N-acetyl-9-O-acetylneuraminate esterase Neighboring gene N-acetylneuraminate outer membrane channel Neighboring gene Type 1 fimbriae regulatory protein FimB

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Function and expression of an N-acetylneuraminic acid-inducible outer membrane channel in Escherichia coli. Condemine G, et al. J Bacteriol, 2005 Mar. PMID 15743943, Free PMC Article
  2. Fishing new proteins in the twilight zone of genomes: the test case of outer membrane proteins in Escherichia coli K12, Escherichia coli O157:H7, and other Gram-negative bacteria. Casadio R, et al. Protein Sci, 2003 Jun. PMID 12761386, Free PMC Article
  3. Identification and functional analysis of 'hypothetical' genes expressed in Haemophilus influenzae. Kolker E, et al. Nucleic Acids Res, 2004. PMID 15121896, Free PMC Article
  4. Comparison of the large-scale periplasmic proteomes of the Escherichia coli K-12 and B strains. Han MJ, et al. J Biosci Bioeng, 2014 Apr. PMID 24140104
  5. Sialic acid mutarotation is catalyzed by the Escherichia coli beta-propeller protein YjhT. Severi E, et al. J Biol Chem, 2008 Feb 22. PMID 18063573

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables isomerase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables racemase and epimerase activity, acting on carbohydrates and derivatives IDA
Inferred from Direct Assay
more info
 PubMed 
enables racemase and epimerase activity, acting on carbohydrates and derivatives IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in N-acetylneuraminate catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in outer membrane-bounded periplasmic space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in periplasmic space IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
N-acetylneuraminate mutarotase
NP_418730.4

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    4537659..4538765 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418730.4 N-acetylneuraminate mutarotase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_418730.4

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A8S7EGH8
    Conserved Domains (2) summary
    PRK14131
    Location:4 → 368
    PRK14131; N-acetylneuraminate epimerase
    sd00038
    Location:75 → 126
    Kelch; KELCH repeat [structural motif]
Nucleotide Protein
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