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fadE acyl-CoA dehydrogenase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 949007, updated on 19-Sep-2024

Summary

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Official Symbol
fadE
Official Full Name
acyl-CoA dehydrogenase
Primary source
ECOCYC:G6105
Locus tag
b0221
See related
ASAP:ABE-0000743
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0222; yafH
Summary
FadR regulon. [More information is available at EcoGene: EG13145]. The previously uncharacterized yafH open reading frame has been shown to encode the FadE acyl-CoA dehydrogenase enzyme . [More information is available at EcoCyc: G6105].
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Genomic context

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Sequence:
NC_000913.3 (240859..243303, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene 2-oxoglutaramate amidase Neighboring gene periplasmic chaperone, inhibitor of vertebrate C-type lysozyme Neighboring gene D-sedoheptulose 7-phosphate isomerase Neighboring gene putative glutamine amidotransferase YafJ Neighboring gene peptidoglycan meso-diaminopimelic acid protein amidase A

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. [Study on regulation of long-chain fatty acid metabolism with the use of computer analysis of complete bacterial genomes]. Sadovskaia NS, et al. Mol Biol (Mosk), 2001 Nov-Dec. PMID 11771124
  2. Fatty acid degradation in Escherichia coli. An inducible system for the uptake of fatty acids and further characterization of old mutants. Klein K, et al. Eur J Biochem, 1971 Apr. PMID 4928881
  3. Evidence for a complex of three beta-oxidation enzymes in Escherichia coli: induction and localization. O'Brien WJ, et al. J Bacteriol, 1977 Nov. PMID 334745, Free PMC Article
  4. Regulation of fatty acid degradation in Escherichia coli: analysis by operon fusion. Clark D. J Bacteriol, 1981 Nov. PMID 6271734, Free PMC Article
  5. The beta-oxidation systems of Escherichia coli and Salmonella enterica are not functionally equivalent. Iram SH, et al. J Bacteriol, 2006 Jan. PMID 16385050, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables acyl-CoA dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables acyl-CoA dehydrogenase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables acyl-CoA dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
  
enables acyl-CoA dehydrogenase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables flavin adenine dinucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables long-chain fatty acyl-CoA dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
  
enables medium-chain fatty acyl-CoA dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in fatty acid beta-oxidation IEA
Inferred from Electronic Annotation
more info
  
involved_in fatty acid beta-oxidation using acyl-CoA dehydrogenase IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fatty acid beta-oxidation using acyl-CoA dehydrogenase IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within fatty acid beta-oxidation using acyl-CoA dehydrogenase IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within fatty acid catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
acyl-CoA dehydrogenase
NP_414756.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    240859..243303 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_414756.2 acyl-CoA dehydrogenase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_414756.2

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A8S7EEN1, A0A8S7I7T9, A0A8T5Z7G2
    Conserved Domains (1) summary
    PRK09463
    Location:42 → 814
    fadE; acyl-CoA dehydrogenase; Reviewed
Nucleotide Protein
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