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radA DNA recombination protein [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948912, updated on 10-Oct-2024

Summary

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Official Symbol
radA
Official Full Name
DNA recombination protein
Primary source
ECOCYC:EG11296
Locus tag
b4389
See related
ASAP:ABE-0014395
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK4381; sms
Summary
RadA is involved in processing of DNA recombination intermediates . [More information is available at EcoCyc: EG11296].
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Genomic context

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Sequence:
NC_000913.3 (4625912..4627294)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative inner membrane protein Smp Neighboring gene phosphoserine phosphatase Neighboring gene DNA-binding transcriptional repressor/NMN adenylyltransferase NadR Neighboring gene energy-dependent translational throttle protein EttA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Recombinational branch migration by the RadA/Sms paralog of RecA in Escherichia coli. Cooper DL, et al. Elife, 2016 Feb 4. PMID 26845522, Free PMC Article
  2. Genetic analysis of Escherichia coli RadA: functional motifs and genetic interactions. Cooper DL, et al. Mol Microbiol, 2015 Mar. PMID 25484163, Free PMC Article
  3. Escherichia coli DNA repair genes radA and sms are the same gene. Song Y, et al. J Bacteriol, 1996 Aug. PMID 8759876, Free PMC Article
  4. Quantitation of the involvement of the recA, recB, recC, recF, recJ, recN, lexA, radA, radB, uvrD, and umuC genes in the repair of X-ray-induced DNA double-strand breaks in Escherichia coli. Sargentini NJ, et al. Radiat Res, 1986 Jul. PMID 3526390
  5. Mutational analysis of the Escherichia coli serB promoter region reveals transcriptional linkage to a downstream gene. Neuwald AF, et al. Gene, 1992 Oct 12. PMID 1327967

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. RadA-mediated branch migration aids recombination by allowing the 3' invading strand to be incorporated into heteroduplex DNA and to be extended by DNA polymerases.
    Title: Recombinational branch migration by the RadA/Sms paralog of RecA in Escherichia coli.
  2. findings show that the putative Zn finger, Walker A motif, KNRXG motif and Lon protease homology domain of the Escherichia coli RadA protein are required for DNA damage survival
    Title: Genetic analysis of Escherichia coli RadA: functional motifs and genetic interactions.
  3. Study shows that enhanced recombination is dependent on the factors: the RuvA Holliday junction helicase, the RecJ single-strand DNA exonuclease, the RadA/Sms RecA-paralog protein of unknown function and, surprisingly, the DinB translesion polymerase.
    Title: Replication arrest-stimulated recombination: Dependence on the RecA paralog, RadA/Sms and translesion polymerase, DinB.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent DNA damage sensor activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent activity, acting on DNA IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables damaged DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables single-stranded DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within DNA repair IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within recombinational repair EXP
Inferred from Experiment
more info
 PubMed 
involved_in recombinational repair IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within recombinational repair IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in recombinational repair IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within response to radiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
DNA recombination protein

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    4625912..4627294
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418806.1 DNA recombination protein [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_418806.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0AAN3TU22
    Conserved Domains (1) summary
    TIGR00416
    Location:1 → 454
    sms; DNA repair protein RadA
Nucleotide Protein
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