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yjjG pyrimidine 5'-nucleotidase YjjG [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948899, updated on 19-Sep-2024

Summary

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Official Symbol
yjjG
Official Full Name
pyrimidine 5'-nucleotidase YjjG
Primary source
ECOCYC:EG12115
Locus tag
b4374
See related
ASAP:ABE-0014344
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK4365
Summary
Efficient in vitro substrates include: dUMP, UMP, and dTMP; phosphoramidase: in vitro activities demonstrated by Kuznetsova et al. [More information is available at EcoGene: EG12115]. YjjG is a monophosphatase whose activity is essential for thymine salvage in a thyA (|FRAME: [More information is available at EcoCyc: EG12115].
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Genomic context

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Sequence:
NC_000913.3 (4608646..4609323)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene 16S rRNA m(2)G1207 methyltransferase Neighboring gene DNA polymerase III subunit psi Neighboring gene protein N-acetyltransferase RimI Neighboring gene peptide chain release factor RF3 Neighboring gene periplasmic chaperone OsmY

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. YjjG, a dUMP phosphatase, is critical for thymine utilization by Escherichia coli K-12. Weiss B. J Bacteriol, 2007 Mar. PMID 17189366, Free PMC Article
  2. A deoxyuridine monophosphate phosphatase detected in mutants of Escherichia coli lacking alkaline phosphatase and 5'-nucleotidase. Uerkvitz W, et al. Mol Gen Genet, 1973 Mar 19. PMID 4571806
  3. The dgt gene of Escherichia coli facilitates thymine utilization in thymine-requiring strains. Itsko M, et al. Mol Microbiol, 2011 Sep. PMID 21736641, Free PMC Article
  4. Multiple stressor-induced proteome responses of Escherichia coli BL21(DE3). Han KY, et al. J Proteome Res, 2008 May. PMID 18363324
  5. Analysis of the Escherichia coli genome VI: DNA sequence of the region from 92.8 through 100 minutes. Burland V, et al. Nucleic Acids Res, 1995 Jun 25. PMID 7610040, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Blockage of the yjjG pathway for deoxyribose-1-phosphate generation greatly exacerbated the severity of thymine starvation in enriched media, and under these conditions the dgt pathway becomes crucial in protecting the cells against thymineless death.
    Title: The dgt gene of Escherichia coli facilitates thymine utilization in thymine-requiring strains.
  2. YjjG, a dUMP phosphatase, is critical for thymine utilization by Escherichia coli K-12.
    Title: YjjG, a dUMP phosphatase, is critical for thymine utilization by Escherichia coli K-12.
  3. identified the presence of nucleotidase activity in three uncharacterized E. coli proteins, SurE, YfbR, and YjjG, that belong to different enzyme superfamilies
    Title: General enzymatic screens identify three new nucleotidases in Escherichia coli. Biochemical characterization of SurE, YfbR, and YjjG.
  4. The substrate spectrum of YjjG suggests that its in vivo substrates are noncanonical pyrimidine derivatives, which might also include oxidized nucleobases such as 5-formyluracil and 5-hydroxyuracil.
    Title: The Escherichia coli protein YjjG is a house-cleaning nucleotidase in vivo.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables 5'-deoxynucleotidase activity IEA
Inferred from Electronic Annotation
more info
  
enables 5'-nucleotidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 5'-nucleotidase activity IEA
Inferred from Electronic Annotation
more info
  
enables XMP 5'-nucleosidase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables manganese ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables thymidylate 5'-phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in pyrimidine nucleobase salvage IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within response to xenobiotic stimulus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in thymine metabolic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
pyrimidine 5'-nucleotidase YjjG
NP_418791.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    4608646..4609323
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418791.1 pyrimidine 5'-nucleotidase YjjG [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_418791.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A8S7CVR0
    Conserved Domains (1) summary
    PRK09449
    Location:1 → 224
    PRK09449; dUMP phosphatase; Provisional
Nucleotide Protein
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