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pepB aminopeptidase B [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948766, updated on 10-Oct-2024

Summary

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Official Symbol
pepB
Official Full Name
aminopeptidase B
Primary source
ECOCYC:EG12310
Locus tag
b2523
See related
ASAP:ABE-0008305
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2520; yfhI
Summary
Aminopeptidase B (PepB) is one of four cysteinylglycinases in Escherichia coli. [More information is available at EcoCyc: EG12310].
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Genomic context

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Sequence:
NC_000913.3 (2655075..2656358, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene putative toxic protein TimP Neighboring gene protein SseB Neighboring gene accessory iron-sulfur cluster assembly protein IscX Neighboring gene reduced ferredoxin

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Characterization of two M17 family members in Escherichia coli, Peptidase A and Peptidase B. Bhosale M, et al. Biochem Biophys Res Commun, 2010 Apr 23. PMID 20350528
  2. Purification and characterization of aminopeptidase B from Escherichia coli K-12. Suzuki H, et al. Biosci Biotechnol Biochem, 2001 Jul. PMID 11515538
  3. Comparison of metal-bound and unbound structures of aminopeptidase B proteins from Escherichia coli and Yersinia pestis. Minasov G, et al. Protein Sci, 2020 Jul. PMID 32306515, Free PMC Article
  4. Escherichia coli peptidase A, B, or N can process translation inhibitor microcin C. Kazakov T, et al. J Bacteriol, 2008 Apr. PMID 18223070, Free PMC Article
  5. Soluble di- and aminopeptidases in Escherichia K-12. Dispensible enzymes. Hermsdorf CL, et al. Int J Pept Protein Res, 1979 Feb. PMID 372108

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Comparison of metal-bound and unbound structures of aminopeptidase B proteins from Escherichia coli and Yersinia pestis.
    Title: Comparison of metal-bound and unbound structures of aminopeptidase B proteins from Escherichia coli and Yersinia pestis.
  2. Data show that PepB can effectively process heptapeptide-nucleotide microcin C (McC).
    Title: Escherichia coli peptidase A, B, or N can process translation inhibitor microcin C.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables aminopeptidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables aminopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables manganese ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metalloaminopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within peptide catabolic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within proteolysis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol HDA PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
aminopeptidase B
NP_417018.4

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2655075..2656358 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417018.4 aminopeptidase B [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_417018.4

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0AAQ2RBQ1
    Conserved Domains (1) summary
    PRK05015
    Location:5 → 427
    PRK05015; aminopeptidase B; Provisional
Nucleotide Protein
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