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CHST10 carbohydrate sulfotransferase 10 [ Homo sapiens (human) ]

Gene ID: 9486, updated on 3-Apr-2024

Summary

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Official Symbol
CHST10provided by HGNC
Official Full Name
carbohydrate sulfotransferase 10provided by HGNC
Primary source
HGNC:HGNC:19650
See related
Ensembl:ENSG00000115526 MIM:606376; AllianceGenome:HGNC:19650
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HNK1ST; HNK-1ST
Summary
This protein encoded by this gene transfers sulfate to the C-3 hydroxyl of terminal glucuronic acid of protein- and lipid-linked oligosaccharides. This protein was first identified as a sulfotransferase that acts on the human natural killer-1 (HNK-1) glycan; HNK-1 is a carbohydrate involved in neurodevelopment and synaptic plasticity.[provided by RefSeq, Feb 2011]
Expression
Broad expression in brain (RPKM 10.4), endometrium (RPKM 4.2) and 21 other tissues See more
Orthologs
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Genomic context

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See CHST10 in Genome Data Viewer
Location:
2q11.2
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (100391860..100417668, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (100850699..100876504, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (101008322..101034130, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11813 Neighboring gene LON peptidase N-terminal domain and ring finger 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:100907393-100908033 Neighboring gene CYCS pseudogene 7 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:101007732-101008232 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:101008233-101008733 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16291 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16292 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16293 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16294 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:101021577-101022078 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:101028413-101028940 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11814 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11815 Neighboring gene RALBP1 pseudogene 2 Neighboring gene uncharacterized LOC105373506 Neighboring gene neuromedin S

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. HNK-1 sulfotransferase modulates α-dystroglycan glycosylation by 3-O-sulfation of glucuronic acid on matriglycan. Sheikh MO, et al. Glycobiology, 2020 Sep 28. PMID 32149355, Free PMC Article
  2. Sulfation of glucuronic acid in the linkage tetrasaccharide by HNK-1 sulfotransferase is an inhibitory signal for the expression of a chondroitin sulfate chain on thrombomodulin. Nakagawa N, et al. Biochem Biophys Res Commun, 2011 Nov 11. PMID 22020094
  3. Mechanism of regulation and suppression of melanoma invasiveness by novel retinoic acid receptor-gamma target gene carbohydrate sulfotransferase 10. Zhao X, et al. Cancer Res, 2009 Jun 15. PMID 19470764
  4. Structure and function of HNK-1 sulfotransferase. Identification of donor and acceptor binding sites by site-directed mutagenesis. Ong E, et al. J Biol Chem, 1999 Sep 3. PMID 10464296
  5. Expression cloning of a human sulfotransferase that directs the synthesis of the HNK-1 glycan on the neural cell adhesion molecule and glycolipids. Ong E, et al. J Biol Chem, 1998 Feb 27. PMID 9478973

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. novel role for HNK-1ST as a tumor suppressor controlling the functional glycans on alpha-DG and the importance of sulfate transfer in the glycosylation of alpha-DG.
    Title: Human natural killer-1 sulfotransferase (HNK-1ST)-induced sulfate transfer regulates laminin-binding glycans on α-dystroglycan.
  2. These results suggest that HNK-1ST is involved in 3-O-sulfation of the terminal GlcA of the linkage tetrasaccharide which acts as an inhibitory signal for the initiation of chondroitin sulfate chain biosynthesis on thrombomodulin.
    Title: Sulfation of glucuronic acid in the linkage tetrasaccharide by HNK-1 sulfotransferase is an inhibitory signal for the expression of a chondroitin sulfate chain on thrombomodulin.
  3. HNK-1ST may be responsible for regulating the sorting of alpha- and beta-TM.
    Title: Involvement of human natural killer-1 (HNK-1) sulfotransferase in the biosynthesis of the GlcUA(3-O-sulfate)-Gal-Gal-Xyl tetrasaccharide found in α-thrombomodulin from human urine.
  4. Observational study and meta-analysis of gene-disease association. (HuGE Navigator)
    Title: Candidate gene analysis of the human natural killer-1 carbohydrate pathway and perineuronal nets in schizophrenia: B3GAT2 is associated with disease risk and cortical surface area.
  5. We show that CHST10 is also regulated by RARgamma in a significant subset of human melanoma cells, and three-dimensional cell culture migration assays suggest that CHST10 functions as a suppressor of invasiveness, but not proliferation, in these cells
    Title: Mechanism of regulation and suppression of melanoma invasiveness by novel retinoic acid receptor-gamma target gene carbohydrate sulfotransferase 10.
  6. identification of a novel member of HNK-1 family of sulfotransferases
    Title: Molecular cloning and characterization of chondroitin-4-O-sulfotransferase-3. A novel member of the HNK-1 family of sulfotransferases.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp160, precursor env Sulfate is linked to the carbohydrate chains of HIV-1 glycoproteins gp160, gp120, and gp41 during the endoplasmic reticulum to Golgi transport of the glycoproteins PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC17148

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables HNK-1 sulfotransferase activity TAS
Traceable Author Statement
more info
  
enables sulfotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sulfotransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in androgen metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in carbohydrate biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in cell adhesion TAS
Traceable Author Statement
more info
 PubMed 
involved_in estrogen metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in learning IEA
Inferred from Electronic Annotation
more info
  
involved_in long-term memory IEA
Inferred from Electronic Annotation
more info
  
involved_in proteoglycan biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus TAS
Traceable Author Statement
more info
 PubMed 
located_in Golgi membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in Golgi membrane TAS
Traceable Author Statement
more info
  
located_in membrane TAS
Traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
carbohydrate sulfotransferase 10
Names
HNK-1 sulfotransferase
huHNK-1ST
NP_004845.1
XP_011510509.1
XP_011510510.1
XP_011510512.1
XP_011510513.1
XP_016860869.1
XP_016860870.1
XP_016860871.1
XP_016860872.1
XP_024309016.1
XP_047302389.1
XP_047302390.1
XP_047302392.1
XP_047302393.1
XP_047302394.1
XP_054200619.1
XP_054200620.1
XP_054200621.1
XP_054200622.1
XP_054200623.1
XP_054200624.1
XP_054200625.1
XP_054200626.1
XP_054200627.1
XP_054200628.1
XP_054200629.1
XP_054200630.1
XP_054200631.1
XP_054200632.1
XP_054200633.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_028153.1 RefSeqGene

    Range
    5001..30809
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_004854.5 → NP_004845.1  carbohydrate sulfotransferase 10

    See identical proteins and their annotated locations for NP_004845.1

    Status: REVIEWED

    Source sequence(s)
    AF033827, AF070594, DA522916, DA732392
    Consensus CDS
    CCDS2047.1
    UniProtKB/Swiss-Prot
    O43529, Q53T18
    UniProtKB/TrEMBL
    B7Z4E8
    Related
    ENSP00000264249.3, ENST00000264249.8
    Conserved Domains (1) summary
    pfam03567
    Location:116 → 348
    Sulfotransfer_2; Sulfotransferase family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    100391860..100417668 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011512210.2 → XP_011510512.1  carbohydrate sulfotransferase 10 isoform X1

    See identical proteins and their annotated locations for XP_011510512.1

    UniProtKB/Swiss-Prot
    O43529, Q53T18
    UniProtKB/TrEMBL
    B7Z4E8
    Conserved Domains (1) summary
    pfam03567
    Location:116 → 348
    Sulfotransfer_2; Sulfotransferase family

  2. XM_017005381.3 → XP_016860870.1  carbohydrate sulfotransferase 10 isoform X1

    UniProtKB/Swiss-Prot
    O43529, Q53T18
    UniProtKB/TrEMBL
    B7Z4E8
    Conserved Domains (1) summary
    pfam03567
    Location:116 → 348
    Sulfotransfer_2; Sulfotransferase family

  3. XM_017005380.3 → XP_016860869.1  carbohydrate sulfotransferase 10 isoform X1

    UniProtKB/Swiss-Prot
    O43529, Q53T18
    UniProtKB/TrEMBL
    B7Z4E8
    Conserved Domains (1) summary
    pfam03567
    Location:116 → 348
    Sulfotransfer_2; Sulfotransferase family

  4. XM_047446433.1 → XP_047302389.1  carbohydrate sulfotransferase 10 isoform X1

    UniProtKB/Swiss-Prot
    O43529, Q53T18

  5. XM_011512207.3 → XP_011510509.1  carbohydrate sulfotransferase 10 isoform X1

    See identical proteins and their annotated locations for XP_011510509.1

    UniProtKB/Swiss-Prot
    O43529, Q53T18
    UniProtKB/TrEMBL
    B7Z4E8
    Conserved Domains (1) summary
    pfam03567
    Location:116 → 348
    Sulfotransfer_2; Sulfotransferase family

  6. XM_011512208.2 → XP_011510510.1  carbohydrate sulfotransferase 10 isoform X1

    See identical proteins and their annotated locations for XP_011510510.1

    UniProtKB/Swiss-Prot
    O43529, Q53T18
    UniProtKB/TrEMBL
    B7Z4E8
    Conserved Domains (1) summary
    pfam03567
    Location:116 → 348
    Sulfotransfer_2; Sulfotransferase family

  7. XM_011512211.2 → XP_011510513.1  carbohydrate sulfotransferase 10 isoform X1

    See identical proteins and their annotated locations for XP_011510513.1

    UniProtKB/Swiss-Prot
    O43529, Q53T18
    UniProtKB/TrEMBL
    B7Z4E8
    Conserved Domains (1) summary
    pfam03567
    Location:116 → 348
    Sulfotransfer_2; Sulfotransferase family

  8. XM_047446437.1 → XP_047302393.1  carbohydrate sulfotransferase 10 isoform X1

    UniProtKB/Swiss-Prot
    O43529, Q53T18

  9. XM_024453248.2 → XP_024309016.1  carbohydrate sulfotransferase 10 isoform X1

    UniProtKB/Swiss-Prot
    O43529, Q53T18
    UniProtKB/TrEMBL
    B7Z4E8
    Conserved Domains (1) summary
    pfam03567
    Location:116 → 348
    Sulfotransfer_2; Sulfotransferase family

  10. XM_047446438.1 → XP_047302394.1  carbohydrate sulfotransferase 10 isoform X1

    UniProtKB/Swiss-Prot
    O43529, Q53T18

  11. XM_017005383.3 → XP_016860872.1  carbohydrate sulfotransferase 10 isoform X1

    UniProtKB/Swiss-Prot
    O43529, Q53T18
    UniProtKB/TrEMBL
    B7Z4E8
    Conserved Domains (1) summary
    pfam03567
    Location:116 → 348
    Sulfotransfer_2; Sulfotransferase family

  12. XM_047446434.1 → XP_047302390.1  carbohydrate sulfotransferase 10 isoform X1

    UniProtKB/Swiss-Prot
    O43529, Q53T18
    Related
    ENSP00000387309.1, ENST00000409701.5

  13. XM_017005382.3 → XP_016860871.1  carbohydrate sulfotransferase 10 isoform X1

    UniProtKB/Swiss-Prot
    O43529, Q53T18
    UniProtKB/TrEMBL
    B7Z4E8
    Conserved Domains (1) summary
    pfam03567
    Location:116 → 348
    Sulfotransfer_2; Sulfotransferase family

  14. XM_047446436.1 → XP_047302392.1  carbohydrate sulfotransferase 10 isoform X1

    UniProtKB/Swiss-Prot
    O43529, Q53T18

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    100850699..100876504 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054344646.1 → XP_054200621.1  carbohydrate sulfotransferase 10 isoform X1

    UniProtKB/Swiss-Prot
    O43529, Q53T18

  2. XM_054344647.1 → XP_054200622.1  carbohydrate sulfotransferase 10 isoform X1

    UniProtKB/Swiss-Prot
    O43529, Q53T18

  3. XM_054344652.1 → XP_054200627.1  carbohydrate sulfotransferase 10 isoform X1

    UniProtKB/Swiss-Prot
    O43529, Q53T18

  4. XM_054344645.1 → XP_054200620.1  carbohydrate sulfotransferase 10 isoform X1

    UniProtKB/Swiss-Prot
    O43529, Q53T18

  5. XM_054344644.1 → XP_054200619.1  carbohydrate sulfotransferase 10 isoform X1

    UniProtKB/Swiss-Prot
    O43529, Q53T18

  6. XM_054344650.1 → XP_054200625.1  carbohydrate sulfotransferase 10 isoform X1

    UniProtKB/Swiss-Prot
    O43529, Q53T18

  7. XM_054344648.1 → XP_054200623.1  carbohydrate sulfotransferase 10 isoform X1

    UniProtKB/Swiss-Prot
    O43529, Q53T18

  8. XM_054344654.1 → XP_054200629.1  carbohydrate sulfotransferase 10 isoform X1

    UniProtKB/Swiss-Prot
    O43529, Q53T18

  9. XM_054344651.1 → XP_054200626.1  carbohydrate sulfotransferase 10 isoform X1

    UniProtKB/Swiss-Prot
    O43529, Q53T18

  10. XM_054344656.1 → XP_054200631.1  carbohydrate sulfotransferase 10 isoform X1

    UniProtKB/Swiss-Prot
    O43529, Q53T18

  11. XM_054344657.1 → XP_054200632.1  carbohydrate sulfotransferase 10 isoform X1

    UniProtKB/Swiss-Prot
    O43529, Q53T18

  12. XM_054344649.1 → XP_054200624.1  carbohydrate sulfotransferase 10 isoform X1

    UniProtKB/Swiss-Prot
    O43529, Q53T18

  13. XM_054344655.1 → XP_054200630.1  carbohydrate sulfotransferase 10 isoform X1

    UniProtKB/Swiss-Prot
    O43529, Q53T18

  14. XM_054344653.1 → XP_054200628.1  carbohydrate sulfotransferase 10 isoform X1

    UniProtKB/Swiss-Prot
    O43529, Q53T18

  15. XM_054344658.1 → XP_054200633.1  carbohydrate sulfotransferase 10 isoform X1

    UniProtKB/Swiss-Prot
    O43529, Q53T18
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O43529.1 GenPept UniProtKB/Swiss-Prot:O43529

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