hinT [Escherichia coli str. K-12 substr. MG1655] - Gene

Summary

Official Symbol: hinT
Primary source: ECOCYC:EG12172
Locus tag: b1103
See related: ASAP:ABE-0003729
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage: Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as: ECK1089; ycfF
Summary: HinT hydrolyzes lysyl-AMP, an activity that may be involved in the regulation of translation or the scavanging of aminoacyl-adenylates (Chou, 2006). hinT is essential for growth under high salt conditions (Chou, 2005). [More information is available at EcoGene: EG12172]. HinT is a purine nucleoside phosphoramidase with a preference for purine nucleoside phosphoramidates. [More information is available at EcoCyc: EG12172].
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NC_000913.3 Genomic Context describing neighboring genes

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evaluation of potential inhibitors of human and Escherichia coli histidine triad nucleotide binding proteins
Title: Synthesis and evaluation of potential inhibitors of human and Escherichia coli histidine triad nucleotide binding proteins.
The ability of the C-terminal deletion mutants to hydrolyze lysyl-AMP generated by LysU was greatly impaired.
Title: Probing the impact of the echinT C-terminal domain on structure and catalysis.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables adenosine 5'-monophosphoramidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables adenosine 5'-monophosphoramidase activity	IDA Inferred from Direct Assay more info	PubMed
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in D-alanine catabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_positive_effect D-alanine catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed

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The following sections contain reference sequences that belong to a specific genome build. Explain