U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

mtn 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948542, updated on 19-Sep-2024

Summary

Go to the top of the page Help
Official Symbol
mtn
Official Full Name
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase
Primary source
ECOCYC:EG11090
Locus tag
b0159
See related
ASAP:ABE-0000545
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0158; mtnN; pfs; yadA
Summary
Mutants accumulate 5'-deoxyadenosine and have impaired biotin synthase activity. [More information is available at EcoGene: EG11090]. The mtn gene encodes 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase . [More information is available at EcoCyc: EG11090].
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Sequence:
NC_000913.3 (178455..179153, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene protein YadW Neighboring gene iron-sulfur cluster insertion protein ErpA Neighboring gene PF03458 family protein YadS Neighboring gene vitamin B12 ABC transporter periplasmic binding protein Neighboring gene dGTP triphosphohydrolase Neighboring gene periplasmic serine endoprotease DegP

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. The catalytic mechanism of adenosylhomocysteine/methylthioadenosine nucleosidase from Escherichia coli--chemical evidence for a transition state with a substantial oxocarbenium character. Allart B, et al. Eur J Biochem, 1998 Aug 15. PMID 9746359
  2. Structure of Escherichia coli 5'-methylthioadenosine/ S-adenosylhomocysteine nucleosidase inhibitor complexes provide insight into the conformational changes required for substrate binding and catalysis. Lee JE, et al. J Biol Chem, 2003 Mar 7. PMID 12496243
  3. pfs-dependent regulation of autoinducer 2 production in Salmonella enterica serovar Typhimurium. Beeston AL, et al. J Bacteriol, 2002 Jul. PMID 12057938, Free PMC Article
  4. Structural rationale for the affinity of pico- and femtomolar transition state analogues of Escherichia coli 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase. Lee JE, et al. J Biol Chem, 2005 May 6. PMID 15746096
  5. Femtomolar transition state analogue inhibitors of 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase from Escherichia coli. Singh V, et al. J Biol Chem, 2005 May 6. PMID 15749708

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The transition-state analogue affinity and thermodynamics in mutant VcMTAN became even more unlike those of EcMTAN, the opposite of expectations from catalytic site similarity
    Title: Active site and remote contributions to catalysis in methylthioadenosine nucleosidases.
  2. Pfs and LuxS synthesize AI-2 in vitro from S-ribosylhomocysteine.
    Title: [Cloning and expression of luxS and pfs and in vitro biosynthesis autoinducer 2 of avian pathogenic Escherichia coli from Anhui Province].
  3. Pfs transcription is shown to rely on both sigma 70 and sigma 38 (rpoS), and the latter is subject to induction that increases pfs expression
    Title: Escherichia coli pfs transcription: regulation and proposed roles in autoinducer-2 synthesis and purine excretion.
  4. transition state structure investigated using multiple kinetic isotope effects and its geometric and electrostatic properties obtained using density functional methods
    Title: Transition state structure of 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase from Escherichia coli and its similarity to transition state analogues.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

General protein information

Go to the top of the page Help
Preferred Names
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase
NP_414701.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    178455..179153 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_414701.1 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_414701.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A376MCL3
    Conserved Domains (1) summary
    PRK05584
    Location:1 → 230
    PRK05584; 5'-methylthioadenosine/adenosylhomocysteine nucleosidase
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.