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pgi glucose-6-phosphate isomerase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948535, updated on 19-Sep-2024

Summary

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Official Symbol
pgi
Official Full Name
glucose-6-phosphate isomerase
Primary source
ECOCYC:EG10702
Locus tag
b4025
See related
ASAP:ABE-0013163
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK4017
Summary
Also called phosphoglucose isomerase. [More information is available at EcoGene: EG10702]. [More information is available at EcoCyc: EG10702].
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Genomic context

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Sequence:
NC_000913.3 (4233758..4235407)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene DUF3811 domain-containing protein YjbD Neighboring gene aspartate kinase III Neighboring gene uncharacterized protein YjbE Neighboring gene lipoprotein YjbF Neighboring gene capsule biosynthesis GfcC family protein YjbG

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Multiple Optimal Phenotypes Overcome Redox and Glycolytic Intermediate Metabolite Imbalances in Escherichia coli pgi Knockout Evolutions. McCloskey D, et al. Appl Environ Microbiol, 2018 Oct 1. PMID 30054360, Free PMC Article
  2. A novel bioluminescent bacterial biosensor using the highly specific oxidative stress-inducible pgi gene. Niazi JH, et al. Biosens Bioelectron, 2008 Dec 1. PMID 18657410
  3. Gene expression patterns for metabolic pathway in pgi knockout Escherichia coli with and without phb genes based on RT-PCR. Kabir MM, et al. J Biotechnol, 2003 Oct 9. PMID 14511906
  4. INTRACELLULAR PH EFFECT UPON PHOSPHOGLUCOSE ISOMERASE IN ESCHERICHIA COLI. KLUNGSOEYR L, et al. Biochim Biophys Acta, 1964 Nov 22. PMID 14249126
  5. Phosphoglucose isomerase from Escherischia coli K 10: purification, properties and formation under aerobic and anaerobic condition. Schreyer R, et al. Arch Microbiol, 1980 Oct. PMID 7004378

See all (44) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Pgi knockout exhibited an 80% drop in growth rate that was largely recovered in eight replicate, but phenotypically distinct, cultures after undergoing adaptive laboratory evolution.
    Title: Multiple Optimal Phenotypes Overcome Redox and Glycolytic Intermediate Metabolite Imbalances in Escherichia coli pgi Knockout Evolutions.
  2. pgi transcription and enzymatic activity are induced under oxidative stress, and is regulated by the SoxRS system.
    Title: Activation of glucose transport under oxidative stress in Escherichia coli.
  3. transformation with different pET-plasmids containing archaeal or bacterial pgi, cpgi or pgi/pmi genes from the three known PGI families (PGI, PGI/PMI, cPGI) restored growth
    Title: Escherichia coli phosphoglucose isomerase can be substituted by members of the PGI family, the PGI/PMI family, and the cPGI family.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables carbohydrate derivative binding IEA
Inferred from Electronic Annotation
more info
  
enables glucose-6-phosphate isomerase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glucose-6-phosphate isomerase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables glucose-6-phosphate isomerase activity IEA
Inferred from Electronic Annotation
more info
  
enables glucose-6-phosphate isomerase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables isomerase activity IEA
Inferred from Electronic Annotation
more info
  
enables monosaccharide binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cellular response to oxidative stress IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within cellular response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in gluconeogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in gluconeogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in glucose 6-phosphate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glycolytic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glycolytic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within glycolytic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol HDA PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
glucose-6-phosphate isomerase
NP_418449.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    4233758..4235407
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418449.1 glucose-6-phosphate isomerase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_418449.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A8S7EC36
    Conserved Domains (1) summary
    PRK00179
    Location:2 → 549
    pgi; glucose-6-phosphate isomerase; Reviewed
Nucleotide Protein
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