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eptC phosphoethanolamine transferase EptC [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948458, updated on 10-Oct-2024

Summary

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Official Symbol
eptC
Official Full Name
phosphoethanolamine transferase EptC
Primary source
ECOCYC:EG11914
Locus tag
b3955
See related
ASAP:ABE-0012947
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3946; yijP
Summary
YijP has similarity to YijP of Escherichia coli K1, which is required for that strain to invade brain microvascular endothelial cells and thereby cross the blood-brain barrier . [More information is available at EcoCyc: EG11914].
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Genomic context

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Sequence:
NC_000913.3 (4148532..4150265, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative formate acetyltransferase 2 Neighboring gene putative pyruvate formate-lyase 2 activating enzyme PflC Neighboring gene putative PTS enzyme IIB component FrwD Neighboring gene putative DNA-binding transcriptional regulator YijO Neighboring gene phosphoenolpyruvate carboxylase Neighboring gene acetylornithine deacetylase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The gene locus yijP contributes to Escherichia coli K1 invasion of brain microvascular endothelial cells. Wang Y, et al. Infect Immun, 1999 Sep. PMID 10456927, Free PMC Article
  2. Identification of cptA, a PmrA-regulated locus required for phosphoethanolamine modification of the Salmonella enterica serovar typhimurium lipopolysaccharide core. Tamayo R, et al. J Bacteriol, 2005 May. PMID 15866924, Free PMC Article
  3. Phosphoethanolamine substitution in the lipid A of Escherichia coli O157 : H7 and its association with PmrC. Kim SH, et al. Microbiology (Reading), 2006 Mar. PMID 16514146
  4. Molecular and structural basis of inner core lipopolysaccharide alterations in Escherichia coli: incorporation of glucuronic acid and phosphoethanolamine in the heptose region. Klein G, et al. J Biol Chem, 2013 Mar 22. PMID 23372159, Free PMC Article
  5. A phosphoethanolamine transferase specific for the outer 3-deoxy-D-manno-octulosonic acid residue of Escherichia coli lipopolysaccharide. Identification of the eptB gene and Ca2+ hypersensitivity of an eptB deletion mutant. Reynolds CM, et al. J Biol Chem, 2005 Jun 3. PMID 15795227

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables phosphotransferase activity, phosphate group as acceptor EXP
Inferred from Experiment
more info
 PubMed 
enables phosphotransferase activity, phosphate group as acceptor IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphotransferase activity, phosphate group as acceptor IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity, transferring phosphorus-containing groups IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in lipopolysaccharide biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in lipopolysaccharide core region biosynthetic process EXP
Inferred from Experiment
more info
 PubMed 
involved_in lipopolysaccharide core region biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in lipopolysaccharide core region biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in lipopolysaccharide core region biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
phosphoethanolamine transferase EptC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    4148532..4150265 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418390.1 phosphoethanolamine transferase EptC [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_418390.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0AAN5FCN4, A0AAN6AB46
    Conserved Domains (1) summary
    NF012179
    Location:13 → 568
    CptA; phosphoethanolamine transferase CptA
Nucleotide Protein
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