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speE spermidine synthase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947726, updated on 19-Sep-2024

Summary

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Official Symbol
speE
Official Full Name
spermidine synthase
Primary source
ECOCYC:EG10963
Locus tag
b0121
See related
ASAP:ABE-0000418
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0120
Summary
Paraquat toxicity observed in cells deficient in spermidine. [More information is available at EcoGene: EG10963].
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Genomic context

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Sequence:
NC_000913.3 (135598..136464, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene PF06062 family protein YacL Neighboring gene S-adenosylmethionine decarboxylase proenzyme Neighboring gene putative lipoprotein YacC Neighboring gene multicopper oxidase CueO

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Site-directed mutations of the gatekeeping loop region affect the activity of Escherichia coli spermidine synthase. Lee MJ, et al. Mol Biotechnol, 2013 Jun. PMID 23001854
  2. The crystal structure of Escherichia coli spermidine synthase SpeE reveals a unique substrate-binding pocket. Zhou X, et al. J Struct Biol, 2010 Mar. PMID 20051267
  3. Mechanism of propylamine-transfer reactions. Kinetic and inhibition studies on spermidine synthase from Escherichia coli. Zappia V, et al. J Biol Chem, 1980 Aug 10. PMID 6993485
  4. Inhibition of bacterial aminopropyltransferases by S-adenosyl-1,8-diamino-3-thiooctane and by dicyclohexylamine. Pegg AE, et al. FEBS Lett, 1983 May 8. PMID 6406265
  5. Putrescine aminopropyltransferase (Escherichia coli). Tabor CW, et al. Methods Enzymol, 1983. PMID 6312268

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Crystal structure of E. coli SpeE reveals that it has a large and unique substrate-binding cleft that may account for its lower amine substrate specificity.
    Title: The crystal structure of Escherichia coli spermidine synthase SpeE reveals a unique substrate-binding pocket.
  2. N-terminus verified by Edman degradation on mature peptide
    Title: Spermidine synthase of Escherichia coli: localization of the speE gene.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables cadaverine aminopropyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables spermidine synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables spermidine synthase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables spermidine synthase activity IEA
Inferred from Electronic Annotation
more info
  
enables spermidine synthase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables spermine synthase activity IEA
Inferred from Electronic Annotation
more info
  
enables thermospermine synthase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables thermospermine synthase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in polyamine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in spermidine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in spermidine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within spermidine biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol HDA PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
spermidine synthase
NP_414663.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    135598..136464 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_414663.1 spermidine synthase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_414663.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A8S7TQ96, A0A8T5ZAE9
    Conserved Domains (1) summary
    PRK00811
    Location:7 → 284
    PRK00811; polyamine aminopropyltransferase
Nucleotide Protein
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