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narQ sensor histidine kinase NarQ [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946948, updated on 10-Oct-2024

Summary

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Official Symbol
narQ
Official Full Name
sensor histidine kinase NarQ
Primary source
ECOCYC:EG11460
Locus tag
b2469
See related
ASAP:ABE-0008132
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2464
Summary
NarQ belongs to the two component system NarQ/NarP, is a sensor-histidine kinase and is known to be a transmembrane protein composed of three domains: external sensory domain (amino-terminal), cytoplasmic transmitter domain (carboxyl-terminal) and transmembrane hydrophobic central domain (unknown funtion). [More information is available at EcoCyc: EG11460].
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Genomic context

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Sequence:
NC_000913.3 (2585731..2587431)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene GDP-mannose hydrolase Neighboring gene putative oxidoreductase AegA Neighboring gene multidrug efflux pump RND permease AcrD Neighboring gene uncharacterized protein YpfM

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mechanism of transmembrane signaling by sensor histidine kinases. Gushchin I, et al. Science, 2017 Jun 9. PMID 28522691
  2. Physical map location of the narQ gene of Escherichia coli. Chiang RC, et al. J Bacteriol, 1992 Dec. PMID 1447165, Free PMC Article
  3. Response to culture aeration mediated by the nitrate and nitrite sensor NarQ of Escherichia coli K-12. Stewart V, et al. Mol Microbiol, 2003 Nov. PMID 14622424
  4. Sensor Histidine Kinase NarQ Activates via Helical Rotation, Diagonal Scissoring, and Eventually Piston-Like Shifts. Gushchin I, et al. Int J Mol Sci, 2020 Apr 28. PMID 32354084, Free PMC Article
  5. Autophosphorylation and dephosphorylation by soluble forms of the nitrate-responsive sensors NarX and NarQ from Escherichia coli K-12. Noriega CE, et al. J Bacteriol, 2008 Jun. PMID 18375557, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Sensor Histidine Kinase NarQ Activates via Helical Rotation, Diagonal Scissoring, and Eventually Piston-Like Shifts.
    Title: Sensor Histidine Kinase NarQ Activates via Helical Rotation, Diagonal Scissoring, and Eventually Piston-Like Shifts.
  2. Study presents crystal structures of the periplasmic sensor domain, the transmembrane domain, and the cytoplasmic HAMP domain of the Escherichia coli nitrate/nitrite sensor histidine kinase NarQ in the ligand-bound and mutated ligand-free states.
    Title: Mechanism of transmembrane signaling by sensor histidine kinases.
  3. Results from bacterial adenylate cyclase two-hybrid analysis revealed robust interactions for the NarX-NarL, NarQ-NarL and NarQ-NarP pairs but a much weaker interaction for the NarX-NarP pair.
    Title: Sensor-response regulator interactions in a cross-regulated signal transduction network.
  4. study showed that only a small proportion of NarX and NarQ remain phosphorylated in the absence of nitrate, resulting in efficient response regulator dephosphorylation by the remaining unphosphorylated sensors
    Title: Autophosphorylation and dephosphorylation by soluble forms of the nitrate-responsive sensors NarX and NarQ from Escherichia coli K-12.
  5. analysis of FNR regulon and its interactions with nitrate, nitrite, NarXL, and NarQP
    Title: A reassessment of the FNR regulon and transcriptomic analysis of the effects of nitrate, nitrite, NarXL, and NarQP as Escherichia coli K12 adapts from aerobic to anaerobic growth.
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Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphorelay sensor kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphorelay sensor kinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein dimerization activity IEA
Inferred from Electronic Annotation
more info
  
enables protein histidine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cellular response to nitrate IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cellular response to nitrite IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nitrate assimilation IEA
Inferred from Electronic Annotation
more info
  
involved_in peptidyl-histidine phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphorelay signal transduction system IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within signal transduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
sensor histidine kinase NarQ
NP_416964.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2585731..2587431
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416964.1 sensor histidine kinase NarQ [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416964.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A376D4L0, A0A8T3UGU9, A0AAQ2LUT9
    Conserved Domains (1) summary
    PRK10935
    Location:1 → 563
    PRK10935; nitrate/nitrite two-component system sensor histidine kinase NarQ
Nucleotide Protein
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