U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

fadL long-chain fatty acid outer membrane channel/bacteriophage T2 receptor [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946820, updated on 10-Oct-2024

Summary

Go to the top of the page Help
Official Symbol
fadL
Official Full Name
long-chain fatty acid outer membrane channel/bacteriophage T2 receptor
Primary source
ECOCYC:EG10280
Locus tag
b2344
See related
ASAP:ABE-0007740
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2338; ttr
Summary
FadL is an outer membrane protein involved with the uptake of long-chain fatty acids . [More information is available at EcoCyc: EG10280].
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Sequence:
NC_000913.3 (2461306..2462646)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene 3-hydroxyacyl-CoA dehydrogenase FadJ Neighboring gene 3-ketoacyl-CoA thiolase FadI Neighboring gene DUF406 domain-containing protein YfcZ Neighboring gene protein YfdF Neighboring gene intermembrane phospholipid transport system - outer membrane lipoprotein MlaA

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. The C-terminal tails of the bacterial chaperonin GroEL stimulate protein folding by directly altering the conformation of a substrate protein. Weaver J, et al. J Biol Chem, 2014 Aug 15. PMID 24970895, Free PMC Article
  2. Ligand-gated diffusion across the bacterial outer membrane. Lepore BW, et al. Proc Natl Acad Sci U S A, 2011 Jun 21. PMID 21593406, Free PMC Article
  3. Transmembrane passage of hydrophobic compounds through a protein channel wall. Hearn EM, et al. Nature, 2009 Mar 19. PMID 19182779, Free PMC Article
  4. Dynamic mechanism of fatty acid transport across cellular membranes through FadL: molecular dynamics simulations. Zou H, et al. J Phys Chem B, 2008 Oct 16. PMID 18811191
  5. The FadL family: unusual transporters for unusual substrates. van den Berg B. Curr Opin Struct Biol, 2005 Aug. PMID 16005205

See all (43) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CRP-cAMP complex directly activates expression of fadL and fadD genes.
    Title: Crosstalk of Escherichia coli FadR with global regulators in expression of fatty acid transport genes.
  2. Data show that high-affinity (submicromolar) substrate binding to the outer membrane long-chain fatty acid transporter FadL from Escherichia coli causes conformational changes in the N terminus that open up a channel for substrate diffusion.
    Title: Ligand-gated diffusion across the bacterial outer membrane.
  3. N-terminus verified by Edman degradation on mature peptide
    Title: Amounts of proteins altered by mutations in the dnaA gene of Escherichia coli.
Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables ligand-gated channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables long-chain fatty acid transporting porin activity EXP
Inferred from Experiment
more info
 PubMed 
enables long-chain fatty acid transporting porin activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables long-chain fatty acid transporting porin activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in lipid transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within long-chain fatty acid transport EXP
Inferred from Experiment
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell outer membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell outer membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
long-chain fatty acid outer membrane channel/bacteriophage T2 receptor

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2461306..2462646
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416846.2 long-chain fatty acid outer membrane channel/bacteriophage T2 receptor [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416846.2

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0AAP7VVP1
    Conserved Domains (1) summary
    PRK10716
    Location:1 → 446
    PRK10716; long-chain fatty acid transporter FadL
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.