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eco serine protease inhibitor ecotin [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946700, updated on 19-Sep-2024

Summary

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Official Symbol
eco
Official Full Name
serine protease inhibitor ecotin
Primary source
ECOCYC:EG10255
Locus tag
b2209
See related
ASAP:ABE-0007297
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2201; eti
Summary
Ecotin inhibits trypsin and a number of additional heterologous proteases . [More information is available at EcoCyc: EG10255].
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Genomic context

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Sequence:
NC_000913.3 (2303905..2304393)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene NapA signal peptide-binding chaperone NapD Neighboring gene ferredoxin-type protein Neighboring gene uncharacterized protein YojO Neighboring gene malate:quinone oxidoreductase Neighboring gene ABC transporter family protein/microcin J25 efflux protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Isolation of a high affinity inhibitor of urokinase-type plasminogen activator by phage display of ecotin. Wang CI, et al. J Biol Chem, 1995 May 19. PMID 7744876
  2. Alteration of the specificity of ecotin, an E. coli serine proteinase inhibitor, by site directed mutagenesis. Pál G, et al. FEBS Lett, 1994 Mar 28. PMID 8143850
  3. Crystallization and preliminary X-ray crystallographic analysis of the protease inhibitor ecotin. Shin DH, et al. J Mol Biol, 1993 Feb 20. PMID 8445642
  4. Trypsin display on the surface of bacteriophage. Corey DR, et al. Gene, 1993 Jun 15. PMID 8508953
  5. Stable monomeric form of an originally dimeric serine proteinase inhibitor, ecotin, was constructed via site directed mutagenesis. Pál G, et al. FEBS Lett, 1996 May 6. PMID 8647243

See all (47) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Synergy of protease-binding sites within the ecotin homodimer is crucial for inhibition of MASP enzymes and for blocking lectin pathway activation.
    Title: Synergy of protease-binding sites within the ecotin homodimer is crucial for inhibition of MASP enzymes and for blocking lectin pathway activation.
  2. Data show that the mass difference in ecotin is likely due to the cross-linker itself.
    Title: Finding chimeras: a bioinformatics strategy for identification of cross-linked peptides.
  3. N-terminus verified by Edman degradation on mature peptide
    Title: Comparing the predicted and observed properties of proteins encoded in the genome of Escherichia coli K-12.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables serine-type endopeptidase inhibitor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables serine-type endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in defense response IC
Inferred by Curator
more info
 PubMed 
involved_in negative regulation of peptidase activity IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in outer membrane-bounded periplasmic space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in periplasmic space IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
serine protease inhibitor ecotin

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2303905..2304393
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416713.1 serine protease inhibitor ecotin [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416713.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A6G4BWX1, A0A839B0M6
    Conserved Domains (1) summary
    COG4574
    Location:1 → 162
    Eco; Serine protease inhibitor ecotin [Posttranslational modification, protein turnover, chaperones]
Nucleotide Protein
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