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fabF 3-oxoacyl-[acyl carrier protein] synthase 2 [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946665, updated on 19-Sep-2024

Summary

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Official Symbol
fabF
Official Full Name
3-oxoacyl-[acyl carrier protein] synthase 2
Primary source
ECOCYC:EG12606
Locus tag
b1095
See related
ASAP:ABE-0003705
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
cvc; ECK1081; fabJ; vtr; vtrB
Summary
There are three -ketoacyl-ACP synthases (KAS) in Escherichia coli: |FRAME: [More information is available at EcoCyc: EG12606].
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Genomic context

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Sequence:
NC_000913.3 (1151939..1153180)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene 3-oxoacyl-[acyl-carrier-protein] reductase FabG Neighboring gene acyl carrier protein Neighboring gene aminodeoxychorismate lyase Neighboring gene endolytic murein transglycosylase Neighboring gene Tmk

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Multiple forms of beta-ketoacyl-acyl carrier protein synthetase in Escherichia coli. D'Agnolo G, et al. J Biol Chem, 1975 Jul 25. PMID 237914
  2. Mutant of Escherichia coli deficient in the synthesis of cis-vaccenic acid. Gelmann EP, et al. J Bacteriol, 1972 Oct. PMID 4562402, Free PMC Article
  3. The putative fabJ gene of Escherichia coli fatty acid synthesis is the fabF gene. Magnuson K, et al. J Bacteriol, 1995 Jun. PMID 7768872, Free PMC Article
  4. Structure of the complex between the antibiotic cerulenin and its target, beta-ketoacyl-acyl carrier protein synthase. Moche M, et al. J Biol Chem, 1999 Mar 5. PMID 10037680
  5. Assessment of Rhodopseudomonas sphaeroides chromatophore membrane asymmetry through bilateral antiserum adsorption studies. Collins ML, et al. J Bacteriol, 1980 Jul. PMID 6967482, Free PMC Article

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These data taken together support a gating mechanism that regulates acyl-ACP binding and substrate delivery to the beta-ketoacyl-acyl carrier protein (ACP) synthases (FabF and FabB) active site.
    Title: Gating mechanism of elongating β-ketoacyl-ACP synthases.
  2. N-terminus verified by Edman degradation on mature peptide
    Title: The fabJ-encoded beta-ketoacyl-[acyl carrier protein] synthase IV from Escherichia coli is sensitive to cerulenin and specific for short-chain substrates.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables 3-oxoacyl-[acyl-carrier-protein] synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 3-oxoacyl-[acyl-carrier-protein] synthase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 3-oxoacyl-[acyl-carrier-protein] synthase activity IEA
Inferred from Electronic Annotation
more info
  
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables acyltransferase activity, transferring groups other than amino-acyl groups IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in fatty acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fatty acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within fatty acid elongation, saturated fatty acid IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within monounsaturated fatty acid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to cold IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in small molecule metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol HDA PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
3-oxoacyl-[acyl carrier protein] synthase 2
NP_415613.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1151939..1153180
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415613.1 3-oxoacyl-[acyl carrier protein] synthase 2 [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415613.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A5B9AKE4
    Conserved Domains (1) summary
    PRK07314
    Location:3 → 413
    PRK07314; beta-ketoacyl-ACP synthase II
Nucleotide Protein
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