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wcaK colanic acid biosynthesis pyruvyl transferase WcaK [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946569, updated on 10-Oct-2024

Summary

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Official Symbol
wcaK
Official Full Name
colanic acid biosynthesis pyruvyl transferase WcaK
Primary source
ECOCYC:G7096
Locus tag
b2045
See related
ASAP:ABE-0006780
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2039
Summary
Overexpression causes a decrease in the amount of biofilm formed. [More information is available at EcoGene: EG13577]. WcaK may be involved in colanic acid synthesis based on sequence and its presence in a putative colanic acid synthesis operon , though there is no evidence suggesting a function for this protein. [More information is available at EcoCyc: G7096].
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Genomic context

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Sequence:
NC_000913.3 (2117124..2118404, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene UTP:glucose-1-phosphate uridylyltransferase, low activity Neighboring gene putative colanic acid biosynthesis protein WcaM Neighboring gene putative colanic acid biosynthesis glycosyl transferase WcaL Neighboring gene colanic acid repeat unit flippase Neighboring gene UDP-glucose:undecaprenyl-phosphate glucose-1-phosphate transferase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Group II intron protein localization and insertion sites are affected by polyphosphate. Zhao J, et al. PLoS Biol, 2008 Jun 24. PMID 18593213, Free PMC Article
  2. Biosynthesis and assembly of capsular polysaccharides in Escherichia coli. Whitfield C. Annu Rev Biochem, 2006. PMID 16756484
  3. Development of a biofilm production-deficient Escherichia coli strain as a host for biotechnological applications. Sung BH, et al. Appl Environ Microbiol, 2006 May. PMID 16672475, Free PMC Article
  4. Genome-wide analyses revealing a signaling network of the RcsC-YojN-RcsB phosphorelay system in Escherichia coli. Hagiwara D, et al. J Bacteriol, 2003 Oct. PMID 13129944, Free PMC Article
  5. Tracking Colanic Acid Repeat Unit Formation from Stepwise Biosynthesis Inactivation in Escherichia coli. Reid AJ, et al. Biochemistry, 2021 Jul 13. PMID 34159784, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within colanic acid biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in lipopolysaccharide biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in slime layer polysaccharide biosynthetic process IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
colanic acid biosynthesis pyruvyl transferase WcaK

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2117124..2118404 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416549.1 colanic acid biosynthesis pyruvyl transferase WcaK [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416549.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A376S9A4, A0A8H9XMI0
    Conserved Domains (1) summary
    TIGR04006
    Location:1 → 426
    wcaK; colanic acid biosynthesis pyruvyl transferase WcaK
Nucleotide Protein
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