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shiA shikimate:H(+) symporter [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946495, updated on 19-Sep-2024

Summary

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Official Symbol
shiA
Official Full Name
shikimate:H(+) symporter
Primary source
ECOCYC:G7067
Locus tag
b1981
See related
ASAP:ABE-0006572
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1976; yeeM
Summary
Major Facilitator Superfamily (MFS). [More information is available at EcoGene: EG20205]. ShiA has been implicated in the high affinity transport of shikimate, an intermediate in the aromatic amino acid biosynthetic pathway . [More information is available at EcoCyc: G7067].
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Genomic context

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Sequence:
NC_000913.3 (2053643..2054959)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene inverse autotransporter adhesin Neighboring gene pseudo Neighboring gene AMP nucleosidase Neighboring gene putative transcriptional regulator YeeN

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Gene controlling the uptake of shikimic acid by Escherichia coli. Pittard J, et al. J Bacteriol, 1966 Oct. PMID 5332864, Free PMC Article
  2. Cloning and analysis of the shiA gene, which encodes the shikimate transport system of escherichia coli K-12. Whipp MJ, et al. Gene, 1998 Mar 16. PMID 9524262
  3. Frequency and mechanism of resistance to antibacterial action of ZM 240401, (6S)-6-fluoro-shikimic acid. Ewart CD, et al. Antimicrob Agents Chemother, 1995 Jan. PMID 7695335, Free PMC Article
  4. Transport and utilization of the biosynthetic intermediate shikimic acid in Escherichia coli. Brown KD, et al. Biochim Biophys Acta, 1976 May 28. PMID 6050
  5. Hydroaromatic equilibration during biosynthesis of shikimic acid. Knop DR, et al. J Am Chem Soc, 2001 Oct 24. PMID 11603966

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables shikimate transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables symporter activity IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within shikimate transmembrane transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
shikimate:H(+) symporter

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2053643..2054959
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416488.1 shikimate:H(+) symporter [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416488.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A376D8Z8
    Conserved Domains (1) summary
    PRK09952
    Location:1 → 438
    PRK09952; shikimate transporter; Provisional
Nucleotide Protein
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