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tpx lipid hydroperoxide peroxidase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945880, updated on 10-Oct-2024

Summary

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Official Symbol
tpx
Official Full Name
lipid hydroperoxide peroxidase
Primary source
ECOCYC:G6660
Locus tag
b1324
See related
ASAP:ABE-0004442
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1320; yzzJ
Summary
Binds TrxA (Kumar, 2004). although initially reported to be a periplasmic enzyme, the formation of a mixed-disulfide complex with TrxA indicates a cytoplasmic localization (Tao, 2008). [More information is available at EcoGene: EG12672]. Tpx is a |FRAME: [More information is available at EcoCyc: G6660].
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Genomic context

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Sequence:
NC_000913.3 (1388305..1388811, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene DUF463 domain-containing protein YcjX Neighboring gene DUF697 domain-containing inner membrane protein YcjF Neighboring gene DNA-binding transcriptional dual regulator TyrR Neighboring gene L-Ala-D/L-Glu epimerase Neighboring gene murein tripeptide amidase A Neighboring gene putative uncharacterized protein YmjC

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The structure of an orthorhombic crystal form of a 'forced reduced' thiol peroxidase reveals lattice formation aided by the presence of the affinity tag. Beckham KS, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2012 May 1. PMID 22691780, Free PMC Article
  2. Structural changes common to catalysis in the Tpx peroxiredoxin subfamily. Hall A, et al. J Mol Biol, 2009 Nov 6. PMID 19699750, Free PMC Article
  3. The dual functions of thiol-based peroxidases in H2O2 scavenging and signaling. Fourquet S, et al. Antioxid Redox Signal, 2008 Sep. PMID 18498222
  4. Escherichia coli periplasmic thiol peroxidase acts as lipid hydroperoxide peroxidase and the principal antioxidative function during anaerobic growth. Cha MK, et al. J Biol Chem, 2004 Mar 5. PMID 14676195
  5. Crystal structure of Escherichia coli thiol peroxidase in the oxidized state: insights into intramolecular disulfide formation and substrate binding in atypical 2-Cys peroxiredoxins. Choi J, et al. J Biol Chem, 2003 Dec 5. PMID 14506251

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Structural alignments revealed that Tpx is conserved
    Title: The structure of an orthorhombic crystal form of a 'forced reduced' thiol peroxidase reveals lattice formation aided by the presence of the affinity tag.
  2. Results describe in detail the structural changes associated with catalysis in the thiol peroxidase subfamily.
    Title: Structural changes common to catalysis in the Tpx peroxiredoxin subfamily.
  3. N-terminus verified by Edman degradation on mature peptide
    Title: Comparing the predicted and observed properties of proteins encoded in the genome of Escherichia coli K-12.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables hydroperoxide reductase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables peroxidase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables thioredoxin peroxidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables thioredoxin peroxidase activity IEA
Inferred from Electronic Annotation
more info
  
enables thioredoxin-dependent peroxiredoxin activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cellular oxidant detoxification IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cellular response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in periplasmic space IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
lipid hydroperoxide peroxidase
NP_415840.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1388305..1388811 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415840.1 lipid hydroperoxide peroxidase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415840.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0AAQ2LM18
    Conserved Domains (1) summary
    PRK00522
    Location:2 → 168
    tpx; thiol peroxidase
Nucleotide Protein
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