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ispE 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945774, updated on 19-Sep-2024

Summary

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Official Symbol
ispE
Official Full Name
4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase
Primary source
ECOCYC:EG11294
Locus tag
b1208
See related
ASAP:ABE-0004056
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1196; ipk; ychB
Summary
[More information is available at EcoCyc: EG11294].
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Genomic context

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Sequence:
NC_000913.3 (1262026..1262877, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene aerobic C4-dicarboxylate transporter DauA Neighboring gene ribose-phosphate diphosphokinase Neighboring gene outer membrane lipoprotein LolB Neighboring gene glutamyl-tRNA reductase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Inhibitors of the kinase IspE: structure-activity relationships and co-crystal structure analysis. Hirsch AK, et al. Org Biomol Chem, 2008 Aug 7. PMID 18633530
  2. Synthesis and characterization of cytidine derivatives that inhibit the kinase IspE of the non-mevalonate pathway for isoprenoid biosynthesis. Crane CM, et al. ChemMedChem, 2008 Jan. PMID 18033714
  3. A triclinic crystal form of Escherichia coli 4-diphosphocytidyl-2C-methyl-D-erythritol kinase and reassessment of the quaternary structure. Kalinowska-Tłuścik J, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2010 Mar 1. PMID 20208151, Free PMC Article
  4. Isopentenyl diphosphate biosynthesis via a mevalonate-independent pathway: isopentenyl monophosphate kinase catalyzes the terminal enzymatic step. Lange BM, et al. Proc Natl Acad Sci U S A, 1999 Nov 23. PMID 10570138, Free PMC Article
  5. Cloning and characterization of genes involved in the biosynthesis of delta-aminolevulinic acid in Escherichia coli. Ikemi M, et al. Gene, 1992 Nov 2. PMID 1427085

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. triclinic crystal structure of the Escherichia coli IspE-ADP complex with two molecules in the asymmetric unit was determined at 2 A resolution.
    Title: A triclinic crystal form of Escherichia coli 4-diphosphocytidyl-2C-methyl-D-erythritol kinase and reassessment of the quaternary structure.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in isoprenoid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in terpenoid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase
NP_415726.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1262026..1262877 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415726.1 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415726.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A776QWR0
    Conserved Domains (1) summary
    PRK00343
    Location:1 → 272
    ipk; 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional
Nucleotide Protein
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