U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

fabD [acyl-carrier-protein] S-malonyltransferase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945766, updated on 3-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
fabD
Official Full Name
[acyl-carrier-protein] S-malonyltransferase
Primary source
ECOCYC:EG11317
Locus tag
b1092
See related
ASAP:ABE-0003698
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1078; tfpA
Summary
The fabD gene is part of a fatty acid biosynthesis operon and the malonyl-CoA transacylase is part of a multienzyme fatty acid synthase II complex. [More information is available at EcoCyc: EG11317].
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Sequence:
NC_000913.3 (1149728..1150657)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative phosphate acyltransferase Neighboring gene 3-oxoacyl-[acyl carrier protein] synthase 3 Neighboring gene 3-oxoacyl-[acyl-carrier-protein] reductase FabG Neighboring gene acyl carrier protein

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. The isolation and general properties of Escherichia coli malonyl coenzyme A-acyl carrier protein transacylase. Ruch FE, et al. J Biol Chem, 1973 Dec 10. PMID 4584822
  2. Characterization of a malonyl-enzyme intermediate and identification of the malonyl binding site in malonyl coenzyme A-acyl carrier protein transacylase of Escherichia coli. Ruch FE, et al. J Biol Chem, 1973 Dec 10. PMID 4584823
  3. Mutants of Escherichia coli with temperature-sensitive malonyl coenzyme A-acyl carrier protein transacylase. Harder ME, et al. J Biol Chem, 1974 Dec 10. PMID 4612036
  4. Studies on the mechanism of fatty acid synthesis. XXVI. Purification and properties of malonyl-coenzyme A--acyl carrier protein transacylase of Escherichia coli. Joshi VC, et al. Arch Biochem Biophys, 1971 Apr. PMID 4934182
  5. Mapping the active site of Escherichia coli malonyl-CoA-acyl carrier protein transacylase (FabD) by protein crystallography. Oefner C, et al. Acta Crystallogr D Biol Crystallogr, 2006 Jun. PMID 16699188

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Interfacial plasticity facilitates high reaction rate of E. coli FAS malonyl-CoA:ACP transacylase, FabD.
    Title: Interfacial plasticity facilitates high reaction rate of E. coli FAS malonyl-CoA:ACP transacylase, FabD.
  2. N-terminus verified by Edman degradation on mature peptide
    Title: Comparing the predicted and observed properties of proteins encoded in the genome of Escherichia coli K-12.
  3. A possible new catalytic enzyme mechanism is discussed for FabD.
    Title: Mapping the active site of Escherichia coli malonyl-CoA-acyl carrier protein transacylase (FabD) by protein crystallography.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables [acyl-carrier-protein] S-malonyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables [acyl-carrier-protein] S-malonyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables [acyl-carrier-protein] S-malonyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in fatty acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fatty acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within fatty acid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
[acyl-carrier-protein] S-malonyltransferase
NP_415610.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1149728..1150657
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415610.1 [acyl-carrier-protein] S-malonyltransferase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415610.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    D0VE86
    Conserved Domains (1) summary
    TIGR00128
    Location:2 → 292
    fabD; malonyl CoA-acyl carrier protein transacylase
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.