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rluC 23S rRNA pseudouridine(955/2504/2580) synthase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945637, updated on 10-Oct-2024

Summary

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Official Symbol
rluC
Official Full Name
23S rRNA pseudouridine(955/2504/2580) synthase
Primary source
ECOCYC:EG11118
Locus tag
b1086
See related
ASAP:ABE-0003675
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1071; yceC
Summary
Ribosome-associated protein (Jiang, 2007). [More information is available at EcoGene: EG11118]. RluC catalyzes pseudouridylation of nucleotides U955, U2504, and U2580 in 23S rRNA; all three sites are located near the peptidyl transferase center of the ribosome . [More information is available at EcoCyc: EG11118].
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Genomic context

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Sequence:
NC_000913.3 (1144940..1145899)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene ribonuclease E Neighboring gene DUF2655 domain-containing protein YceQ Neighboring gene m(7)GTP pyrophosphatase Neighboring gene ncRNA Neighboring gene DUF177 domain-containing protein YceD

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Suppression of DeltabipA phenotypes in Escherichia coli by abolishment of pseudouridylation at specific sites on the 23S rRNA. Krishnan K, et al. J Bacteriol, 2008 Dec. PMID 18820021, Free PMC Article
  2. Analysis of the altered mRNA stability (ams) gene from Escherichia coli. Nucleotide sequence, transcriptional analysis, and homology of its product to MRP3, a mitochondrial ribosomal protein from Neurospora crassa. Claverie-Martin F, et al. J Biol Chem, 1991 Feb 15. PMID 1704367
  3. Role of DNA supercoiling and rpoS sigma factor in the osmotic and growth phase-dependent induction of the gene osmE of Escherichia coli K12. Conter A, et al. J Mol Biol, 1997 Oct 17. PMID 9367747
  4. Crystal structures of the catalytic domains of pseudouridine synthases RluC and RluD from Escherichia coli. Mizutani K, et al. Biochemistry, 2004 Apr 20. PMID 15078091
  5. Physical locations of genes in the rne (ams)-rpmF-plsX-fab region of the Escherichia coli K-12 chromosome. Oh W, et al. J Bacteriol, 1992 Dec. PMID 1447160, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables 23S rRNA pseudouridine(955/2504/2580) synthase activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables isomerase activity IEA
Inferred from Electronic Annotation
more info
  
enables pseudouridine synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables pseudouridine synthase activity IEA
Inferred from Electronic Annotation
more info
  
enables rRNA pseudouridine synthase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables rRNA pseudouridine synthase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in enzyme-directed rRNA pseudouridine synthesis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within enzyme-directed rRNA pseudouridine synthesis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in enzyme-directed rRNA pseudouridine synthesis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within enzyme-directed rRNA pseudouridine synthesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in pseudouridine synthesis IEA
Inferred from Electronic Annotation
more info
  
involved_in rRNA processing IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
23S rRNA pseudouridine(955/2504/2580) synthase
NP_415604.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1144940..1145899
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415604.1 23S rRNA pseudouridine(955/2504/2580) synthase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415604.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0AAN3UGQ1
    Conserved Domains (1) summary
    PRK11025
    Location:1 → 319
    PRK11025; 23S rRNA pseudouridine(955/2504/2580) synthase RluC
Nucleotide Protein
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