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hcaD putative 3-phenylpropionate/cinnamate dioxygenase ferredoxin reductase subunit [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945427, updated on 19-Sep-2024

Summary

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Official Symbol
hcaD
Official Full Name
putative 3-phenylpropionate/cinnamate dioxygenase ferredoxin reductase subunit
Primary source
ECOCYC:G7336
Locus tag
b2542
See related
ASAP:ABE-0008363
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2539; hcaa4; phdA; yfhY
Summary
Hydrocinnamic acid is a synonym for 3-phenylpropionic acid. [More information is available at EcoGene: EG13460]. The 3-phenylpropionate dioxygenase component is the product of the hcaA1 and hcaA2 genes. [More information is available at EcoCyc: G7336].
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Genomic context

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Sequence:
NC_000913.3 (2672047..2673249)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative 3-phenylpropionate/cinnamate dioxygenase subunit alpha Neighboring gene putative 3-phenylpropionate/cinnamate dioxygenase subunit beta Neighboring gene putative 3-phenylpropionate/cinnamate dioxygenase ferredoxin subunit Neighboring gene 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase Neighboring gene putative inner membrane protein Neighboring gene putative aldose 1-epimerase YphB

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. 3-phenylpropionate catabolism and the Escherichia coli oxidative stress response. Turlin E, et al. Res Microbiol, 2005 Apr. PMID 15808934
  2. Isolation and characterization of Escherichia coli mutants defective for phenylpropionate degradation. Burlingame RP, et al. J Bacteriol, 1986 Oct. PMID 3531186, Free PMC Article
  3. Flavoprotein disulfide reductases: advances in chemistry and function. Argyrou A, et al. Prog Nucleic Acid Res Mol Biol, 2004. PMID 15210329
  4. Characterization of the hca cluster encoding the dioxygenolytic pathway for initial catabolism of 3-phenylpropionic acid in Escherichia coli K-12. Díaz E, et al. J Bacteriol, 1998 Jun. PMID 9603882, Free PMC Article
  5. The binary protein-protein interaction landscape of Escherichia coli. Rajagopala SV, et al. Nat Biotechnol, 2014 Mar. PMID 24561554, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables 3-phenylpropionate dioxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables ferredoxin-NAD+ reductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on NAD(P)H IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in 3-phenylpropionate catabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within 3-phenylpropionate catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in 3-phenylpropionate catabolic process NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in catabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of 3-phenylpropionate dioxygenase complex NAS
Non-traceable Author Statement
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
putative 3-phenylpropionate/cinnamate dioxygenase ferredoxin reductase subunit
NP_417037.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2672047..2673249
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417037.1 putative 3-phenylpropionate/cinnamate dioxygenase ferredoxin reductase subunit [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_417037.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A376WZD0
    Conserved Domains (1) summary
    PRK09754
    Location:1 → 396
    PRK09754; phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional
Nucleotide Protein
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