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arnF undecaprenyl-phosphate-alpha-L-Ara4N flippase - ArnF subunit [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945344, updated on 19-Sep-2024

Summary

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Official Symbol
arnF
Official Full Name
undecaprenyl-phosphate-alpha-L-Ara4N flippase - ArnF subunit
Primary source
ECOCYC:G7171
Locus tag
b2258
See related
ASAP:ABE-0007466
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2252; yfbJ
Summary
Involved in the modification of lipid A phosphates with aminoarabinose that is required for polymyxin B and cationic antimicrobial peptide resistance. [More information is available at EcoGene: EG14094]. ArnF is an integral membrane component of the ArnE/ArnF undecaprenyl-phosphate--L-Ara4N flippase. [More information is available at EcoCyc: G7171].
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Genomic context

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Sequence:
NC_000913.3 (2372892..2373278)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene fused UDP-4-amino-4-deoxy-L-arabinose formyltransferase/UDP-glucuronate dehydrogenase Neighboring gene putative 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD Neighboring gene lipid IVA 4-amino-4-deoxy-L-arabinosyltransferase Neighboring gene undecaprenyl-phosphate-alpha-L-Ara4N flippase - ArnE subunit Neighboring gene signal transduction protein PmrD Neighboring gene o-succinylbenzoate--CoA ligase Neighboring gene o-succinylbenzoate synthase Neighboring gene 1,4-dihydroxy-2-naphthoyl-CoA synthase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The pleiotropic two-component regulatory system PhoP-PhoQ. Groisman EA. J Bacteriol, 2001 Mar. PMID 11222580, Free PMC Article
  2. Fe(III)-mediated cellular toxicity. Chamnongpol S, et al. Mol Microbiol, 2002 Aug. PMID 12139617
  3. Role of Mg2+ and pH in the modification of Salmonella lipid A after endocytosis by macrophage tumour cells. Gibbons HS, et al. Mol Microbiol, 2005 Jan. PMID 15659161
  4. An undecaprenyl phosphate-aminoarabinose flippase required for polymyxin resistance in Escherichia coli. Yan A, et al. J Biol Chem, 2007 Dec 7. PMID 17928292, Free PMC Article
  5. Accumulation of a polyisoprene-linked amino sugar in polymyxin-resistant Salmonella typhimurium and Escherichia coli: structural characterization and transfer to lipid A in the periplasm. Trent MS, et al. J Biol Chem, 2001 Nov 16. PMID 11535605

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables carbohydrate derivative transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables carbohydrate derivative transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within carbohydrate derivative transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in lipid A biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in lipopolysaccharide biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within response to iron(III) ion IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within response to iron(III) ion IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
undecaprenyl-phosphate-alpha-L-Ara4N flippase - ArnF subunit

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2372892..2373278
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416761.4 undecaprenyl-phosphate-alpha-L-Ara4N flippase - ArnF subunit [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416761.4

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A1X3JEH5
    Conserved Domains (1) summary
    PRK02971
    Location:1 → 128
    PRK02971; 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional
Nucleotide Protein
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