U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

hscC chaperone protein HscC [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945218, updated on 19-Sep-2024

Summary

Go to the top of the page Help
Official Symbol
hscC
Official Full Name
chaperone protein HscC
Primary source
ECOCYC:G6357
Locus tag
b0650
See related
ASAP:ABE-0002225
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0643; ybeW
Summary
dnaK, hscA, hscC and yegD are paralogs. [More information is available at EcoGene: EG13653]. HscC (Hsc62) is an Escherichia coli-specific member of the Hsc66 subfamily of Hsp70-family chaperones . [More information is available at EcoCyc: G6357].
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Sequence:
NC_000913.3 (681723..683393, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene Sel1 repeat-containing protein YbeT Neighboring gene DUF1266 domain-containing protein YbeU Neighboring gene co-chaperone DjlC Neighboring gene pyrimidine-specific ribonucleoside hydrolase RihA Neighboring gene glutamate/aspartate ABC transporter ATP binding subunit Neighboring gene glutamate/aspartate ABC transporter membrane subunit GltK

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Phylogenetic analysis of the third hsp70 homolog in Escherichia coli; a novel member of the Hsc66 subfamily and its possible co-chaperone. Itoh T, et al. DNA Res, 1999 Oct 29. PMID 10574456
  2. Hsc62, Hsc56, and GrpE, the third Hsp70 chaperone system of Escherichia coli. Yoshimune K, et al. Biochem Biophys Res Commun, 2002 May 24. PMID 12054669
  3. The Hsp70 chaperone machines of Escherichia coli: a paradigm for the repartition of chaperone functions. Genevaux P, et al. Mol Microbiol, 2007 Nov. PMID 17919282
  4. Not all J domains are created equal: implications for the specificity of Hsp40-Hsp70 interactions. Hennessy F, et al. Protein Sci, 2005 Jul. PMID 15987899, Free PMC Article
  5. The ATPase domain of HscC (DnaK homolog) is essential for interfering sigma70 activity in E. coli. Arifuzzaman M, et al. FEMS Microbiol Lett, 2004 Jan 15. PMID 14734171

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATP hydrolysis activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ATP-dependent protein folding chaperone IEA
Inferred from Electronic Annotation
more info
  
enables heat shock protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein folding chaperone IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in chaperone cofactor-dependent protein refolding IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein refolding IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within response to stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
chaperone protein HscC

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    681723..683393 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415183.1 chaperone protein HscC [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415183.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A377DWA4
    Conserved Domains (1) summary
    cd10235
    Location:8 → 343
    HscC_like_NBD; Nucleotide-binding domain of Escherichia coli HscC and similar proteins
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.