U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

accA acetyl-CoA carboxyltransferase subunit alpha [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 944895, updated on 10-Oct-2024

Summary

Go to the top of the page Help
Official Symbol
accA
Official Full Name
acetyl-CoA carboxyltransferase subunit alpha
Primary source
ECOCYC:EG11647
Locus tag
b0185
See related
ASAP:ABE-0000630
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0184
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Sequence:
NC_000913.3 (208621..209580)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene lipid A disaccharide synthase Neighboring gene RNase HII Neighboring gene DNA polymerase III subunit alpha Neighboring gene lysine decarboxylase 2 Neighboring gene VOC domain-containing protein YaeR

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Acetyl CoA carboxylase, II. Deomonstration of biotin-protein and biotin carboxylase subunits. Alberts AW, et al. Proc Natl Acad Sci U S A, 1969 Aug. PMID 4901473, Free PMC Article
  2. A bisubstrate analog inhibitor of the carboxyltransferase component of acetyl-CoA carboxylase. Levert KL, et al. Biochem Biophys Res Commun, 2002 Mar 15. PMID 11883946
  3. Overexpression and kinetic characterization of the carboxyltransferase component of acetyl-CoA carboxylase. Blanchard CZ, et al. J Biol Chem, 1998 Jul 24. PMID 9668099
  4. Acetyl CoA carboxylase. I. Requirement for two protein fractions. Alberts AW, et al. Proc Natl Acad Sci U S A, 1968 Feb. PMID 4868901, Free PMC Article
  5. The structure of the carboxyltransferase component of acetyl-coA carboxylase reveals a zinc-binding motif unique to the bacterial enzyme. Bilder P, et al. Biochemistry, 2006 Feb 14. PMID 16460018

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. N-terminus verified by Edman degradation on mature peptide
    Title: Comparing the predicted and observed properties of proteins encoded in the genome of Escherichia coli K-12.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables acetyl-CoA carboxylase activity IEA
Inferred from Electronic Annotation
more info
  
enables carboxyl- or carbamoyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in fatty acid biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in fatty acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within fatty acid biosynthetic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within fatty acid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within long-chain fatty acid biosynthetic process NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in malonyl-CoA biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in malonyl-CoA biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of acetate CoA-transferase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of acetyl-CoA carboxylase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of acetyl-CoA carboxylase complex IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IC
Inferred by Curator
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
acetyl-CoA carboxyltransferase subunit alpha
NP_414727.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    208621..209580
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_414727.1 acetyl-CoA carboxyltransferase subunit alpha [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_414727.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0AAN5UG88
    Conserved Domains (1) summary
    PRK05724
    Location:1 → 318
    PRK05724; acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.