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hscA iron-sulfur cluster biosynthesis chaperone HscA [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 944885, updated on 19-Sep-2024

Summary

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Official Symbol
hscA
Official Full Name
iron-sulfur cluster biosynthesis chaperone HscA
Primary source
ECOCYC:EG12130
Locus tag
b2526
See related
ASAP:ABE-0008315
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2523; hsc
Summary
dnaK, hscA, hscC and yegD are paralogs. [More information is available at EcoGene: EG12130]. Hsc66 together with Hsc20 may comprise a chaperone system similar to DnaK/DnaJ . [More information is available at EcoCyc: EG12130].
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Genomic context

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Sequence:
NC_000913.3 (2657085..2658935, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene accessory iron-sulfur cluster assembly protein IscX Neighboring gene reduced ferredoxin Neighboring gene [Fe-S] cluster biosynthesis co-chaperone HscB Neighboring gene iron-sulfur cluster insertion protein IscA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Role of the DnaK and HscA homologs of Hsp70 chaperones in protein folding in E.coli. Hesterkamp T, et al. EMBO J, 1998 Aug 17. PMID 9707441, Free PMC Article
  2. Kinetic characterization of the ATPase cycle of the molecular chaperone Hsc66 from Escherichia coli. Silberg JJ, et al. J Biol Chem, 2000 Mar 17. PMID 10713091
  3. Molecular chaperones HscA/Ssq1 and HscB/Jac1 and their roles in iron-sulfur protein maturation. Vickery LE, et al. Crit Rev Biochem Mol Biol, 2007 Mar-Apr. PMID 17453917
  4. Structural determinants of HscA peptide-binding specificity. Tapley TL, et al. Biochemistry, 2006 Jul 4. PMID 16800630
  5. Tuning of chaperone activity of Hsp70 proteins by modulation of nucleotide exchange. Brehmer D, et al. Nat Struct Biol, 2001 May. PMID 11323718

See all (41) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables ADP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables ATP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATP hydrolysis activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent protein folding chaperone IEA
Inferred from Electronic Annotation
more info
  
enables heat shock protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein folding chaperone IBA
Inferred from Biological aspect of Ancestor
more info
  
enables unfolded protein binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cellular response to cold IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in chaperone cofactor-dependent protein refolding IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in iron-sulfur cluster assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in protein folding IEA
Inferred from Electronic Annotation
more info
  
involved_in protein maturation by iron-sulfur cluster transfer IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein maturation by iron-sulfur cluster transfer IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein refolding IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
part_of iron-sulfur cluster transfer complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
iron-sulfur cluster biosynthesis chaperone HscA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2657085..2658935 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417021.1 iron-sulfur cluster biosynthesis chaperone HscA [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_417021.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A830SGK2
    Conserved Domains (1) summary
    PRK05183
    Location:1 → 616
    hscA; chaperone protein HscA; Provisional
Nucleotide Protein
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