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P polymerase [ Hepatitis B virus ]

Gene ID: 944565, updated on 18-Jul-2024

Summary

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Gene symbol
P
Gene description
polymerase
Locus tag
HBVgp1
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Hepatitis B virus (strain: ayw)
Lineage
Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes; Blubervirales; Hepadnaviridae; Orthohepadnavirus
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Genomic context

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Sequence:
NC_003977.2 (2309..3182)
NC_003977.2 (1..1625)

NC_003977.2Genomic Context describing neighboring genes Neighboring gene large envelope protein;middle envelope protein;small envelope protein Neighboring gene X protein Neighboring gene capsid protein;pre-capsid protein Neighboring gene large envelope protein;middle envelope protein;small envelope protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003977.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. rtE218G, a novel hepatitis B virus mutation with resistance to adefovir dipivoxil in patients with chronic hepatitis B. Liu LJ, et al. J Viral Hepat, 2010 Mar. PMID 20586936
  2. Clonal evolution of hepatitis B virus polymerase gene mutations during lamivudine-adefovir combination treatment. Ko SY, et al. World J Gastroenterol, 2012 Nov 28. PMID 23197889, Free PMC Article
  3. Genotype-specific mutations in the polymerase gene of hepatitis B virus potentially associated with resistance to oral antiviral therapy. Mirandola S, et al. Antiviral Res, 2012 Dec. PMID 23026293
  4. Evolution of adefovir-resistant HBV polymerase gene variants after switching to tenofovir disoproxil fumarate monotherapy. van Bömmel F, et al. Antivir Ther, 2012. PMID 22892524
  5. Correlation of the occurrence of YMDD mutations with HBV genotypes, HBV-DNA levels, and HBeAg status in Chinese patients with chronic hepatitis B during lamivudine treatment. Wu F, et al. Hepatobiliary Pancreat Dis Int, 2012 Apr. PMID 22484586

See all (48) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Hepatitis B virus polymerase restricts LINE-1 mobility.
    Title: Hepatitis B virus polymerase restricts LINE-1 mobility.
  2. Persistent Hepatitis B Viraemia with Polymerase Mutations among HIV/HBV Co-Infected Patients on HBV-Active ART in KwaZulu-Natal, South Africa.
    Title: Persistent Hepatitis B Viraemia with Polymerase Mutations among HIV/HBV Co-Infected Patients on HBV-Active ART in KwaZulu-Natal, South Africa.
  3. Characterization of Hepatitis B virus polymerase mutations A194T and CYEI and tenofovir disoproxil fumarate or tenofovir alafenamide resistance.
    Title: Characterization of Hepatitis B virus polymerase mutations A194T and CYEI and tenofovir disoproxil fumarate or tenofovir alafenamide resistance.
  4. Mutational characterization of HBV reverse transcriptase gene and the genotype-phenotype correlation of antiviral resistance among Chinese chronic hepatitis B patients.
    Title: Mutational characterization of HBV reverse transcriptase gene and the genotype-phenotype correlation of antiviral resistance among Chinese chronic hepatitis B patients.
  5. Association of HBsAg mutation patterns with hepatitis B infection outcome: Asymptomatic carriers versus HCC/cirrhotic patients.
    Title: Association of HBsAg mutation patterns with hepatitis B infection outcome: Asymptomatic carriers versus HCC/cirrhotic patients.
  6. findings suggested that HBV reverse transcriptase showed a strong conservative tendency and a majority of their natural mutations were derived from the same genetic changes in the S gene.
    Title: A strong conservative tendency in HBV transcriptase (RT): a majority of natural RT mutations derived from the S gene.
  7. The authors found that the majority of Pol localized to the mitochondria in cells undergoing viral replication.
    Title: Hepatitis B Virus Polymerase Localizes to the Mitochondria, and Its Terminal Protein Domain Contains the Mitochondrial Targeting Signal.
  8. The growth promoting effect of due to large core gene deletion in HBV polymerase was partly due to polymerase overexpression, leading to binding inhibition of microRNA-100 and up-regulation of PLK1.
    Title: HBV polymerase overexpression due to large core gene deletion enhances hepatoma cell growth by binding inhibition of microRNA-100.
  9. this study suggests that substitution at rt269 in HBV polymerase is associated with multi-drug resistance, which may serve as a novel compensatory mutation for replication-defective multi-drug resistant HBV.
    Title: Substitution at rt269 in Hepatitis B Virus Polymerase Is a Compensatory Mutation Associated with Multi-Drug Resistance.
  10. A report on mutations and variations within the polymerase gene of HBV isolated from patients.
    Title: Subgenotypes and mutations in the s and polymerase genes of hepatitis B virus carriers in the West Bank, palestine.
Submit: New GeneRIF Correction See all GeneRIFs (45)

General gene information

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regulatory

  • Loc: 1592-1602

General protein information

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Preferred Names
polymerase

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003977.2 Reference assembly

    Range
    2309..3182, 1..1625
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_009173866.1 polymerase [Hepatitis B virus]

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P03156, P04484
    UniProtKB/TrEMBL
    A0A0A7R703, A0A2P1E6C6, H6UNA0, H6UNA4, Q2F516
Nucleotide Protein
Heading Accession and Version

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