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ZNF264 zinc finger protein 264 [ Homo sapiens (human) ]

Gene ID: 9422, updated on 23-Mar-2024

Summary

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Official Symbol
ZNF264provided by HGNC
Official Full Name
zinc finger protein 264provided by HGNC
Primary source
HGNC:HGNC:13057
See related
Ensembl:ENSG00000083844 MIM:604668; AllianceGenome:HGNC:13057
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a zinc finger protein and belongs to the krueppel C2H2-type zinc-finger protein family. Zinc finger proteins are often localized in the nucleus, bind nucleic acids, and regulate transcription. [provided by RefSeq, Jan 2010]
Expression
Ubiquitous expression in thyroid (RPKM 2.8), testis (RPKM 2.6) and 25 other tissues See more
Orthologs
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Genomic context

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See ZNF264 in Genome Data Viewer
Location:
19q13.43
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (57191500..57222846)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (60288010..60319383)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (57702868..57734214)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene double homeobox A Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11071 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15123 Neighboring gene uncharacterized LOC124904780 Neighboring gene pentatricopeptide repeat domain 3 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15124 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15125 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15126 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11072 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15127 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15128 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11073 Neighboring gene aurora kinase C Neighboring gene Sharpr-MPRA regulatory region 2652 Neighboring gene zinc finger protein 805

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Imprinting and evolution of two Kruppel-type zinc-finger genes, ZIM3 and ZNF264, located in the PEG3/USP29 imprinted domain. Kim J, et al. Genomics, 2001 Sep. PMID 11543637
  2. Wnt signaling and Dupuytren's disease. Dolmans GH, et al. N Engl J Med, 2011 Jul 28. PMID 21732829
  3. Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro. Ishikawa K, et al. DNA Res, 1997 Oct 31. PMID 9455477
  4. Human POGZ modulates dissociation of HP1alpha from mitotic chromosome arms through Aurora B activation. Nozawa RS, et al. Nat Cell Biol, 2010 Jul. PMID 20562864
  5. The DNA sequence and biology of human chromosome 19. Grimwood J, et al. Nature, 2004 Apr 1. PMID 15057824

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Copy number response

Description
Copy number response
Haploinsufficency

No evidence available (Last evaluated 2012-05-10)

ClinGen Genome Curation Page
Triplosensitivity

No evidence available (Last evaluated 2012-05-10)

ClinGen Genome Curation Page

EBI GWAS Catalog

Description
Wnt signaling and Dupuytren's disease.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 264

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016432.1 RefSeqGene

    Range
    5001..36347
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_003417.5 → NP_003408.1  zinc finger protein 264

    See identical proteins and their annotated locations for NP_003408.1

    Status: REVIEWED

    Source sequence(s)
    AB007872, AC005261, AK292504, BF063192
    Consensus CDS
    CCDS33127.1
    UniProtKB/Swiss-Prot
    A8K8Y9, O43296, Q9P1V0
    Related
    ENSP00000263095.5, ENST00000263095.10
    Conserved Domains (6) summary
    smart00349
    Location:14 → 74
    KRAB; krueppel associated box
    COG5048
    Location:184 → 568
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:485 → 505
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:399 → 421
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:14 → 53
    KRAB; KRAB box
    pfam13465
    Location:413 → 438
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    57191500..57222846
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011527522.3 → XP_011525824.1  zinc finger protein 264 isoform X2

    Conserved Domains (6) summary
    smart00349
    Location:14 → 56
    KRAB; krueppel associated box
    COG5048
    Location:152 → 536
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:453 → 473
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:367 → 389
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:14 → 53
    KRAB; KRAB box
    pfam13465
    Location:381 → 406
    zf-H2C2_2; Zinc-finger double domain

  2. XM_047439724.1 → XP_047295680.1  zinc finger protein 264 isoform X1

    UniProtKB/Swiss-Prot
    A8K8Y9, O43296, Q9P1V0

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    60288010..60319383
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054322684.1 → XP_054178659.1  zinc finger protein 264 isoform X1

    UniProtKB/TrEMBL
    Q14C61, Q14C62

  2. XM_054322685.1 → XP_054178660.1  zinc finger protein 264 isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O43296.1 GenPept UniProtKB/Swiss-Prot:O43296

Gene LinkOut

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