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Cabin1 calcineurin binding protein 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 94165, updated on 2-Nov-2024

Summary

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Symbol
Cabin1provided by RGD
Full Name
calcineurin binding protein 1provided by RGD
Primary source
RGD:620263
See related
EnsemblRapid:ENSRNOG00000001237 AllianceGenome:RGD:620263
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Cain
Summary
Enables protein domain specific binding activity and protein phosphatase 2B binding activity. Involved in negative regulation of apoptotic process and response to activity. Predicted to be located in aggresome; cytosol; and nucleoplasm. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in ovarian carcinoma. Orthologous to human CABIN1 (calcineurin binding protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 62.0), Lung (RPKM 59.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Cabin1 in Genome Data Viewer
Location:
20p12
Exon count:
38
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (12892750..13014801)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (12893314..13015357)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (13836032..13963003)

Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134483890 Neighboring gene glutathione S-transferase, theta 3 Neighboring gene D-dopachrome tautomerase Neighboring gene uncharacterized LOC102556116 Neighboring gene sushi domain containing 2 Neighboring gene U6 spliceosomal RNA Neighboring gene gamma-glutamyltransferase 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Knocking down Cabin1 induces glomerular podocyte injury. Wen Y, et al. Int Urol Nephrol, 2018 May. PMID 29368245
  2. Upregulation of Cabin1 During Injury to Renal Tubular Epithelial Cells in Rats. Wen Y, et al. Iran J Kidney Dis, 2017 Nov. PMID 29190603
  3. Gene expression profiling of exercise-induced cardiac hypertrophy in rats. Iemitsu M, et al. Acta Physiol Scand, 2005 Dec. PMID 16266368
  4. Cain, a novel physiologic protein inhibitor of calcineurin. Lai MM, et al. J Biol Chem, 1998 Jul 17. PMID 9660798
  5. Effect of the knockdown of Cabin1 on p53 in glomerular podocyte. Wen Y, et al. J Recept Signal Transduct Res, 2016. PMID 26400065

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Cabin1 involves in renal tubular epithelial cells mitochondrial dysfunction through SIRT1/p53 pathway.
    Title: Cabin1 involves in renal tubular epithelial cells mitochondrial dysfunction through SIRT1/p53 pathway.
  2. Knocking down Cabin1 induces the disruption of cytoskeleton and mitochondrial dysfunction in podocyte. Cabin1 could be a crucial factor in podocyte damage.
    Title: Knocking down Cabin1 induces glomerular podocyte injury.
  3. Injury to renal tubular epithelial cells results in up-regulation of cabin1 expression.
    Title: Upregulation of Cabin1 During Injury to Renal Tubular Epithelial Cells in Rats.
  4. In conclusion, Cabin1 expression significantly increases during podocyte injury. Knockdown of Cabin1 induces p53 expression decrease in cultured podocyte. Cabin1 may provide a new target to investigate podocyte injury.
    Title: Effect of the knockdown of Cabin1 on p53 in glomerular podocyte.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
contributes_to nucleosome binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein domain specific binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein phosphatase 2B binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein phosphatase inhibitor activity TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in chromatin organization IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nucleosome assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in nucleosome assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in response to activity IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
located_in aggresome IEA
Inferred from Electronic Annotation
more info
  
located_in aggresome ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
calcineurin-binding protein cabin-1
Names
calcineurin inhibitor
calcineurin-binding protein cabin-1-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053575.2 → NP_446027.2  calcineurin-binding protein cabin-1

    See identical proteins and their annotated locations for NP_446027.2

    Status: VALIDATED

    Source sequence(s)
    AF061947, DV716961, JAXUCZ010000020
    UniProtKB/Swiss-Prot
    O88480
    UniProtKB/TrEMBL
    A0A1W2Q6J1, A6JKH7
    Related
    ENSRNOP00000076295.1, ENSRNOT00000093157.3
    Conserved Domains (4) summary
    PHA03247
    Location:1914 → 2156
    PHA03247; large tegument protein UL36; Provisional
    COG0457
    Location:34 → 210
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:90 → 118
    TPR; TPR repeat [structural motif]
    pfam09047
    Location:2118 → 2152
    MEF2_binding; MEF2 binding

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086038.1 Reference GRCr8

    Range
    12892750..13014801
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039099132.2 → XP_038955060.1  calcineurin-binding protein cabin-1 isoform X3

    Conserved Domains (2) summary
    COG0457
    Location:34 → 210
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:90 → 118
    TPR; TPR repeat [structural motif]

  2. XM_063279580.1 → XP_063135650.1  calcineurin-binding protein cabin-1 isoform X2

  3. XM_039099130.2 → XP_038955058.1  calcineurin-binding protein cabin-1 isoform X1

    UniProtKB/Swiss-Prot
    O88480
    Conserved Domains (4) summary
    PHA03247
    Location:1885 → 2127
    PHA03247; large tegument protein UL36; Provisional
    COG0457
    Location:34 → 210
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:90 → 118
    TPR; TPR repeat [structural motif]
    pfam09047
    Location:2089 → 2123
    MEF2_binding; MEF2 binding

RNA

  1. XR_005497345.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O88480.1 GenPept UniProtKB/Swiss-Prot:O88480

Gene LinkOut

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