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Trim11 tripartite motif-containing 11 [ Mus musculus (house mouse) ]

Gene ID: 94091, updated on 5-Nov-2024

Summary

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Official Symbol
Trim11provided by MGI
Official Full Name
tripartite motif-containing 11provided by MGI
Primary source
MGI:MGI:2137355
See related
Ensembl:ENSMUSG00000020455 AllianceGenome:MGI:2137355
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables protein domain specific binding activity and ubiquitin protein ligase activity. Involved in several processes, including defense response to symbiont; negative regulation of viral transcription; and regulation of viral entry into host cell. Located in cytoplasm and nucleus. Is expressed in several structures, including gut; hemolymphoid system gland; nervous system; submandibular gland primordium; and urinary system. Orthologous to human TRIM11 (tripartite motif containing 11). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in thymus adult (RPKM 23.0), spleen adult (RPKM 15.4) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Trim11 in Genome Data Viewer
Location:
11 B1.3; 11 36.4 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (58865054..58882288)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (58973726..58991462)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E114 Neighboring gene STARR-positive B cell enhancer ABC_E5230 Neighboring gene STARR-positive B cell enhancer ABC_E6989 Neighboring gene RIKEN cDNA 2310058D17 gene Neighboring gene H2A clustered histone 25 Neighboring gene tripartite motif-containing 17 Neighboring gene STARR-seq mESC enhancer starr_29613 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:58796334-58796535 Neighboring gene H3.4 histone, cluster member Neighboring gene obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF Neighboring gene predicted gene 10435 Neighboring gene STARR-seq mESC enhancer starr_29614 Neighboring gene STARR-positive B cell enhancer ABC_E5231 Neighboring gene IBA57 homolog, iron-sulfur cluster assembly

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. TRIM11 expression levels was downregulated and prevents ferroptosis of cardiomyocyte by Dusp6 in acute myocardial infarction. Wu X, et al. Anticancer Drugs, 2024 Sep 1. PMID 38718254
  2. A tripartite motif protein TRIM11 binds and destabilizes Humanin, a neuroprotective peptide against Alzheimer's disease-relevant insults. Niikura T, et al. Eur J Neurosci, 2003 Mar. PMID 12670303
  3. Regulation of KDM5C stability and enhancer reprogramming in breast cancer. Xiao Q, et al. Cell Death Dis, 2022 Oct 3. PMID 36192394, Free PMC Article
  4. General anesthetics activate a nociceptive ion channel to enhance pain and inflammation. Matta JA, et al. Proc Natl Acad Sci U S A, 2008 Jun 24. PMID 18574153, Free PMC Article
  5. Trim11 modulates the function of neurogenic transcription factor Pax6 through ubiquitin-proteosome system. Tuoc TC, et al. Genes Dev, 2008 Jul 15. PMID 18628401, Free PMC Article

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TRIM11 expression levels was downregulated and prevents ferroptosis of cardiomyocyte by Dusp6 in acute myocardial infarction.
    Title: TRIM11 expression levels was downregulated and prevents ferroptosis of cardiomyocyte by Dusp6 in acute myocardial infarction.
  2. TRIM11 attenuates Treg cell differentiation by p62-selective autophagic degradation of AIM2.
    Title: TRIM11 attenuates Treg cell differentiation by p62-selective autophagic degradation of AIM2.
  3. TRIM11 suppresses AIM2 inflammasome by degrading AIM2 via p62-dependent selective autophagy.
    Title: TRIM11 Suppresses AIM2 Inflammasome by Degrading AIM2 via p62-Dependent Selective Autophagy.
  4. The results suggest that TRIM11 plays a role in the regulation of intracellular humanin level through ubiquitin-mediated protein degradation pathways.
    Title: A tripartite motif protein TRIM11 binds and destabilizes Humanin, a neuroprotective peptide against Alzheimer's disease-relevant insults.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein domain specific binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-macromolecule adaptor activity ISO
Inferred from Sequence Orthology
more info
  
enables protein-macromolecule adaptor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables transcription factor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in innate immune response IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in innate immune response ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of AIM2 inflammasome complex assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of AIM2 inflammasome complex assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of neurogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of viral entry into host cell IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of viral entry into host cell IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of viral entry into host cell ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of viral transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of viral transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of viral transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of viral entry into host cell IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of viral entry into host cell ISO
Inferred from Sequence Orthology
more info
  
involved_in protein autoubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in protein autoubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in suppression of viral release by host IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in suppression of viral release by host IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in suppression of viral release by host ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
E3 ubiquitin-protein ligase TRIM11
Names
RING-type E3 ubiquitin transferase TRIM11
tripartite motif-containing protein 11
NP_001277917.1
NP_444398.1
XP_006534642.1
XP_011247637.1
XP_030102306.1
XP_036013004.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290988.1 → NP_001277917.1  E3 ubiquitin-protein ligase TRIM11 isoform 1

    See identical proteins and their annotated locations for NP_001277917.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK040618, AK139477, AL662809
    Consensus CDS
    CCDS70195.1
    UniProtKB/Swiss-Prot
    Q99PQ2
    Related
    ENSMUSP00000104438.4, ENSMUST00000108810.10
    Conserved Domains (3) summary
    pfam00643
    Location:87 → 127
    zf-B_box; B-box zinc finger
    pfam15227
    Location:16 → 56
    zf-C3HC4_4; zinc finger of C3HC4-type, RING
    cl02614
    Location:303 → 471
    SPRY; SPRY domain

  2. NM_053168.2 → NP_444398.1  E3 ubiquitin-protein ligase TRIM11 isoform 2

    See identical proteins and their annotated locations for NP_444398.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
    Source sequence(s)
    AK040618, AK139477, AL662809
    Consensus CDS
    CCDS36168.1
    UniProtKB/Swiss-Prot
    A2A868, A2AB84, Q3TCL5, Q8VDX5, Q99PQ2
    Related
    ENSMUSP00000090749.7, ENSMUST00000093061.7
    Conserved Domains (3) summary
    pfam00643
    Location:87 → 127
    zf-B_box; B-box zinc finger
    pfam15227
    Location:16 → 56
    zf-C3HC4_4; zinc finger of C3HC4-type, RING
    cl02614
    Location:287 → 455
    SPRY; SPRY domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    58865054..58882288
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036157111.1 → XP_036013004.1  E3 ubiquitin-protein ligase TRIM11 isoform X1

    Conserved Domains (4) summary
    COG1196
    Location:132 → 234
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00162
    Location:16 → 56
    RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
    cl00034
    Location:90 → 131
    Bbox_SF; B-box-type zinc finger superfamily
    cl17238
    Location:13 → 57
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

  2. XM_006534579.4 → XP_006534642.1  E3 ubiquitin-protein ligase TRIM11 isoform X3

    UniProtKB/TrEMBL
    A2AB83
    Conserved Domains (4) summary
    COG1196
    Location:132 → 234
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00162
    Location:16 → 56
    RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
    cl00034
    Location:90 → 131
    Bbox_SF; B-box-type zinc finger superfamily
    cl17238
    Location:13 → 57
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

  3. XM_030246446.2 → XP_030102306.1  E3 ubiquitin-protein ligase TRIM11 isoform X2

    Conserved Domains (1) summary
    cl02614
    Location:135 → 303
    SPRY; SPRY domain

  4. XM_011249335.4 → XP_011247637.1  E3 ubiquitin-protein ligase TRIM11 isoform X4

    Conserved Domains (1) summary
    cl02614
    Location:62 → 230
    SPRY; SPRY domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99PQ2.1 GenPept UniProtKB/Swiss-Prot:Q99PQ2

Gene LinkOut

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