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LENG9 leukocyte receptor cluster member 9 [ Homo sapiens (human) ]

Gene ID: 94059, updated on 5-Mar-2024

Summary

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Official Symbol
LENG9provided by HGNC
Official Full Name
leukocyte receptor cluster member 9provided by HGNC
Primary source
HGNC:HGNC:16306
See related
Ensembl:ENSG00000275183 AllianceGenome:HGNC:16306
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable metal ion binding activity. [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See LENG9 in Genome Data Viewer
Location:
19q13.42
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (54461732..54463778, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (57555012..57557061, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (54972912..54974961, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene LIM domain-containing protein A-like Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:54933359-54934162 Neighboring gene tweety family member 1 Neighboring gene Sharpr-MPRA regulatory region 3780 Neighboring gene LENG8 antisense RNA 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:54960127-54961034 Neighboring gene leukocyte receptor cluster member 8 Neighboring gene CDC42 effector protein 5 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_51709 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:55018677-55019177 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:55020667-55021482 Neighboring gene leukocyte associated immunoglobulin like receptor 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Extensive gene duplications and a large inversion characterize the human leukocyte receptor cluster. Wende H, et al. Immunogenetics, 2000 Jul. PMID 10941842
  2. Image-based genome-wide siRNA screen identifies selective autophagy factors. Orvedahl A, et al. Nature, 2011 Dec 1. PMID 22020285, Free PMC Article
  3. Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice. Llères D, et al. EMBO Rep, 2010 Jun. PMID 20467437, Free PMC Article
  4. Mutual regulation between OGT and XIAP to control colon cancer cell growth and invasion. Seo HG, et al. Cell Death Dis, 2020 Sep 29. PMID 32994395, Free PMC Article
  5. Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. Li X, et al. Mol Syst Biol, 2015 Jan 21. PMID 25609649, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
leukocyte receptor cluster member 9
Names
leukocyte receptor cluster (LRC) member 9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001301782.2 → NP_001288711.1  leukocyte receptor cluster member 9

    Status: VALIDATED

    Source sequence(s)
    AC245884, CA450132
    Consensus CDS
    CCDS77358.1
    UniProtKB/TrEMBL
    A0A087WVD1
    Related
    ENSP00000479355.1, ENST00000611161.2
    Conserved Domains (3) summary
    smart00356
    Location:24 → 39
    ZnF_C3H1; zinc finger
    pfam10469
    Location:297 → 477
    AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain
    cl00661
    Location:87 → 138
    DUF504; Protein of unknown function (DUF504)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    54461732..54463778 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NW_003571054.1 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    368246..370292 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_7

Genomic

  1. NW_003571060.1 Reference GRCh38.p14 ALT_REF_LOCI_7

    Range
    366320..368654 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_045181401.2 → XP_045037336.1  leukocyte receptor cluster member 9 isoform X1

    UniProtKB/Swiss-Prot
    B2VAM3, Q96B70
    Conserved Domains (3) summary
    pfam04457
    Location:87 → 160
    DUF504; Protein of unknown function (DUF504)
    pfam18345
    Location:46 → 61
    zf_CCCH_4; Zinc finger domain
    cl26521
    Location:320 → 500
    AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain

Reference GRCh38.p14 ALT_REF_LOCI_9

Genomic

  1. NT_187693.1 Reference GRCh38.p14 ALT_REF_LOCI_9

    Range
    443926..446260 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_045181402.2 → XP_045037337.1  leukocyte receptor cluster member 9 isoform X2

    UniProtKB/Swiss-Prot
    B2VAM3, Q96B70
    Conserved Domains (3) summary
    pfam04457
    Location:87 → 160
    DUF504; Protein of unknown function (DUF504)
    pfam18345
    Location:46 → 61
    zf_CCCH_4; Zinc finger domain
    cl26521
    Location:320 → 500
    AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    57555012..57557061 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_198988.2: Suppressed sequence

    Description
    NM_198988.2: This RefSeq was removed because there were mismatches and indels compared to available sequence data. One of the mismatches resulted in the use of an upstream start codon, which is not supported by available homology data.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96B70.2 GenPept UniProtKB/Swiss-Prot:Q96B70

Gene LinkOut

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