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P2rx5 purinergic receptor P2X, ligand-gated ion channel, 5 [ Mus musculus (house mouse) ]

Gene ID: 94045, updated on 28-Oct-2024

Summary

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Official Symbol
P2rx5provided by MGI
Official Full Name
purinergic receptor P2X, ligand-gated ion channel, 5provided by MGI
Primary source
MGI:MGI:2137026
See related
Ensembl:ENSMUSG00000005950 AllianceGenome:MGI:2137026
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
P2X5
Summary
Enables extracellularly ATP-gated monoatomic cation channel activity. Predicted to be involved in several processes, including positive regulation of calcium ion import across plasma membrane; regulation of skeletal muscle tissue regeneration; and response to ATP. Predicted to act upstream of or within cell surface receptor signaling pathway. Predicted to be located in cytosol. Predicted to be active in plasma membrane. Is expressed in several structures, including forelimb bud; nervous system; neural ectoderm; olfactory epithelium; and retina. Orthologous to human P2RX5 (purinergic receptor P2X 5). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Broad expression in heart adult (RPKM 2.0), mammary gland adult (RPKM 2.0) and 21 other tissues See more
Orthologs
human all
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Genomic context

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See P2rx5 in Genome Data Viewer
Location:
11 B4; 11 45.25 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (73029164..73063509)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (73155389..73172687)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E5246 Neighboring gene nuclear cap binding subunit 3 Neighboring gene STARR-positive B cell enhancer mm9_chr11:72885264-72885564 Neighboring gene STARR-seq mESC enhancer starr_29927 Neighboring gene integrin alpha E, epithelial-associated Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:72921846-72921999 Neighboring gene STARR-seq mESC enhancer starr_29929 Neighboring gene histone H3 associated protein kinase Neighboring gene STARR-positive B cell enhancer ABC_E1141 Neighboring gene Tax1 (human T cell leukemia virus type I) binding protein 3 Neighboring gene ER membrane protein complex subunit 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The purinergic receptor P2X5 regulates inflammasome activity and hyper-multinucleation of murine osteoclasts. Kim H, et al. Sci Rep, 2017 Mar 15. PMID 28298636, Free PMC Article
  2. Expression of P2X5 receptors in the mouse CNS. Guo W, et al. Neuroscience, 2008 Oct 15. PMID 18773945
  3. Gene structure, chromosomal localization, cDNA cloning and expression of the mouse ATP-gated ionotropic receptor P2X5 subunit. Cox JA, et al. Gene, 2001 May 30. PMID 11404011
  4. Mice Lacking the Purinergic Receptor P2X5 Exhibit Defective Inflammasome Activation and Early Susceptibility to Listeria monocytogenes. Jeong YH, et al. J Immunol, 2020 Aug 1. PMID 32540996, Free PMC Article
  5. Developmental expression of P2X5 receptors in the mouse prenatal central and peripheral nervous systems. Guo W, et al. Purinergic Signal, 2013 Jun. PMID 23271560, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mice Lacking the Purinergic Receptor P2X5 Exhibit Defective Inflammasome Activation and Early Susceptibility to Listeria monocytogenes.
    Title: Mice Lacking the Purinergic Receptor P2X5 Exhibit Defective Inflammasome Activation and Early Susceptibility to Listeria monocytogenes.
  2. Results identify P2X5 as highly expressed during the osteoclasts (OCs) maturation phase and demonstrate that P2X5 is required for ATP-mediated inflammasome activation and IL-1beta production by OCs, and that P2X5-deficient OC maturation is rescued in vitro by addition of exogenous IL-1beta.
    Title: The purinergic receptor P2X5 regulates inflammasome activity and hyper-multinucleation of murine osteoclasts.
  3. The amino acid transporter PAT2 and the purinergic receptor P2RX5 are cell surface markers expressed in classical brown and beige adipocytes.
    Title: ASC-1, PAT2, and P2RX5 are cell surface markers for white, beige, and brown adipocytes.
  4. Real-time PCR showed that P2XRs except P2X5R were expressed in Bone Marrow and spleen macrophages.
    Title: Functional expression of P2X family receptors in macrophages is affected by microenvironment in mouse T cell acute lymphoblastic leukemia.
  5. transient high expression pattern of P2X5 receptors in epithelium-like structures suggests a role during early neurogenesis
    Title: Developmental expression of P2X5 receptors in the mouse prenatal central and peripheral nervous systems.
  6. This study provides the first evidence that P2X5 receptors are expressed on LHRH-containing neurons.
    Title: P2X receptors are expressed on neurons containing luteinizing hormone-releasing hormone in the mouse hypothalamus.
  7. The identification of extensive P2X5 receptor immunoreactivity and mRNA distribution within the CNS of the mouse demonstrated here is consistent with a role for extracellular ATP acting as a fast neurotransmitter.
    Title: Expression of P2X5 receptors in the mouse CNS.
  8. Immunoreactivity for P2X3-, P2X5-, and P2X6-purinoceptors was observed in mouse retina.
    Title: Distribution of immunoreactivity for P2X3, P2X5, and P2X6-purinoceptors in mouse retina.
  9. sequential expression of the P2X5, P2Y1, and P2X2 receptors during the process of muscle regeneration
    Title: Purinoceptor expression in regenerating skeletal muscle in the mdx mouse model of muscular dystrophy and in satellite cell cultures.
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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (3) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding ISO
Inferred from Sequence Orthology
more info
  
enables ATP-gated ion channel activity ISO
Inferred from Sequence Orthology
more info
  
enables extracellularly ATP-gated monoatomic cation channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables extracellularly ATP-gated monoatomic cation channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables extracellularly ATP-gated monoatomic cation channel activity ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables ligand-gated monoatomic anion channel activity ISO
Inferred from Sequence Orthology
more info
  
enables voltage-gated monoatomic ion channel activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in calcium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cell surface receptor signaling pathway TAS
Traceable Author Statement
more info
 PubMed 
involved_in chloride transport ISO
Inferred from Sequence Orthology
more info
  
involved_in monoatomic cation transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of calcium ion import across plasma membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of skeletal muscle tissue regeneration ISO
Inferred from Sequence Orthology
more info
  
involved_in response to ATP ISO
Inferred from Sequence Orthology
more info
  
involved_in response to calcium ion ISO
Inferred from Sequence Orthology
more info
  
involved_in response to pH ISO
Inferred from Sequence Orthology
more info
  
involved_in response to zinc ion ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IC
Inferred by Curator
more info
 PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
P2X purinoceptor 5
Names
purinergic receptor P2X5-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001376982.1 → NP_001363911.1  P2X purinoceptor 5 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL670399
    UniProtKB/TrEMBL
    B7ZND5
    Conserved Domains (1) summary
    TIGR00863
    Location:1 → 373
    P2X; cation transporter protein

  2. NM_001376983.1 → NP_001363912.1  P2X purinoceptor 5 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL670399
    UniProtKB/TrEMBL
    B7ZND5
    Related
    ENSMUSP00000121834.2, ENSMUST00000136894.3
    Conserved Domains (1) summary
    TIGR00863
    Location:1 → 373
    P2X; cation transporter protein

  3. NM_001424833.1 → NP_001411762.1  P2X purinoceptor 5 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL670399

  4. NM_001425088.1 → NP_001412017.1  P2X purinoceptor 5 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL670399

  5. NM_001425089.1 → NP_001412018.1  P2X purinoceptor 5 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL670399

  6. NM_033321.4 → NP_201578.2  P2X purinoceptor 5 isoform 1

    See identical proteins and their annotated locations for NP_201578.2

    Status: VALIDATED

    Source sequence(s)
    AL670399
    Consensus CDS
    CCDS24998.1
    UniProtKB/Swiss-Prot
    B9EHM6, Q3UYI1, Q91VE2
    UniProtKB/TrEMBL
    B7ZND5
    Related
    ENSMUSP00000006104.4, ENSMUST00000006104.10
    Conserved Domains (1) summary
    TIGR00863
    Location:1 → 373
    P2X; cation transporter protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    73029164..73063509
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91VE2.2 GenPept UniProtKB/Swiss-Prot:Q91VE2

Gene LinkOut

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