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Tm2d1 TM2 domain containing 1 [ Mus musculus (house mouse) ]

Gene ID: 94043, updated on 18-Sep-2024

Summary

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Official Symbol
Tm2d1provided by MGI
Official Full Name
TM2 domain containing 1provided by MGI
Primary source
MGI:MGI:2137022
See related
Ensembl:ENSMUSG00000028563 AllianceGenome:MGI:2137022
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Bbp; 2310026L18Rik
Summary
Enables G protein-coupled receptor activity and amyloid-beta binding activity. Acts upstream of or within apoptotic signaling pathway. Is integral component of plasma membrane. Orthologous to human TM2D1 (TM2 domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 15.6), placenta adult (RPKM 15.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Tm2d1 in Genome Data Viewer
Location:
4 C6; 4 45.6 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (98243607..98271523, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (98355370..98383265, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_10844 Neighboring gene STARR-seq mESC enhancer starr_10845 Neighboring gene predicted gene 12787 Neighboring gene RIKEN cDNA 0610025J13 gene Neighboring gene STARR-seq mESC enhancer starr_10846 Neighboring gene STARR-seq mESC enhancer starr_10847 Neighboring gene PATJ, crumbs cell polarity complex component Neighboring gene STARR-seq mESC enhancer starr_10849 Neighboring gene STARR-seq mESC enhancer starr_10850 Neighboring gene predicted gene, 40210 Neighboring gene ornithine decarboxylase, structural 1 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. beta -Amyloid peptide-induced apoptosis regulated by a novel protein containing a g protein activation module. Kajkowski EM, et al. J Biol Chem, 2001 Jun 1. PMID 11278849
  2. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
  3. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
  4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G protein-coupled receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables amyloid-beta binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables amyloid-beta binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in apoptotic signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within apoptotic signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
TM2 domain-containing protein 1
Names
amyloid-beta-binding protein
beta-amyloid binding protein
mBBP

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053157.2 → NP_444387.1  TM2 domain-containing protein 1 precursor

    See identical proteins and their annotated locations for NP_444387.1

    Status: PROVISIONAL

    Source sequence(s)
    BC089492
    Consensus CDS
    CCDS18374.1
    UniProtKB/Swiss-Prot
    A2ADR1, A2ADR4, Q99MB3
    Related
    ENSMUSP00000099855.5, ENSMUST00000102793.11
    Conserved Domains (1) summary
    pfam05154
    Location:118 → 167
    TM2; TM2 domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    98243607..98271523 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036164579.1 → XP_036020472.1  TM2 domain-containing protein 1 isoform X1

    Conserved Domains (1) summary
    pfam05154
    Location:118 → 167
    TM2; TM2 domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99MB3.1 GenPept UniProtKB/Swiss-Prot:Q99MB3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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