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CPA5 carboxypeptidase A5 [ Homo sapiens (human) ]

Gene ID: 93979, updated on 3-Apr-2024

Summary

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Official Symbol
CPA5provided by HGNC
Official Full Name
carboxypeptidase A5provided by HGNC
Primary source
HGNC:HGNC:15722
See related
Ensembl:ENSG00000158525 MIM:609561; AllianceGenome:HGNC:15722
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Carboxypeptidases have functions ranging from digestion of food to selective biosynthesis of neuroendocrine peptides. Members of the A/B subfamily of carboxypeptidases, such as CPA5, contain an approximately 90-amino acid pro region that assists in the folding of the active carboxypeptidase domain. Cleavage of the pro region activates the enzyme (Wei et al., 2002 [PubMed 11836249]).[supplied by OMIM, Mar 2008]
Expression
Restricted expression toward testis (RPKM 7.8) See more
Orthologs
mouse all
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Genomic context

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See CPA5 in Genome Data Viewer
Location:
7q32.2
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (130344816..130374599)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (131658548..131682444)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (129984656..130008571)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene carboxypeptidase A4 Neighboring gene uncharacterized LOC105375503 Neighboring gene small nucleolar RNA U13 Neighboring gene small nucleolar RNA U13 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:129985848-129986818 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26653 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26654 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:129992089-129992735 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:130005327-130005828 Neighboring gene uncharacterized LOC105375504 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18645 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:130019942-130020463 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26655 Neighboring gene carboxypeptidase A1 Neighboring gene centrosomal protein 41 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:130080543-130081297

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The imprinted region on human chromosome 7q32 extends to the carboxypeptidase A gene cluster: an imprinted candidate for Silver-Russell syndrome. Bentley L, et al. J Med Genet, 2003 Apr. PMID 12676894, Free PMC Article
  2. A full genome screen for autism with evidence for linkage to a region on chromosome 7q. International Molecular Genetic Study of Autism Consortium. . Hum Mol Genet, 1998 Mar. PMID 9546821
  3. Mutation screening and imprinting analysis of four candidate genes for autism in the 7q32 region. Bonora E, et al. Mol Psychiatry, 2002. PMID 11920156
  4. Identification and characterization of three members of the human metallocarboxypeptidase gene family. Wei S, et al. J Biol Chem, 2002 Apr 26. PMID 11836249
  5. A synthetic interaction screen identifies factors selectively required for proliferation and TERT transcription in p53-deficient human cancer cells. Xie L, et al. PLoS Genet, 2012. PMID 23284306, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. mutation screening and imprinting analysis of candidate genes for autism in the 7q12 region.
    Title: Mutation screening and imprinting analysis of four candidate genes for autism in the 7q32 region.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • FLJ35969

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metallocarboxypeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
carboxypeptidase A5
Names
testicular tissue protein Li 32
NP_001120913.1
NP_001120914.1
NP_001305152.1
NP_525124.3
XP_005250767.1
XP_005250769.1
XP_011515000.1
XP_011515005.1
XP_024302767.1
XP_024302768.1
XP_024302769.1
XP_047276991.1
XP_047276992.1
XP_047276993.1
XP_047276994.1
XP_047276995.1
XP_054215322.1
XP_054215323.1
XP_054215324.1
XP_054215325.1
XP_054215326.1
XP_054215327.1
XP_054215328.1
XP_054215329.1
XP_054215330.1
XP_054215331.1
XP_054215332.1
XP_054215333.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001127441.2 → NP_001120913.1  carboxypeptidase A5 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001120913.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 4 encode the same isoform (1).
    Source sequence(s)
    BC039362, BC053681, BK000187, KF495711
    Consensus CDS
    CCDS5819.1
    UniProtKB/Swiss-Prot
    G3V0G8, Q6ZNI6, Q86SE2, Q86XM3, Q8NA08, Q8WXQ8
    UniProtKB/TrEMBL
    A4D1M2, B2RCS8
    Conserved Domains (2) summary
    cd03870
    Location:134 → 434
    M14_CPA; Peptidase M14 carboxypeptidase subfamily A/B-like; Carboxypeptidase A subgroup
    pfam02244
    Location:48 → 117
    Propep_M14; Carboxypeptidase activation peptide

  2. NM_001127442.2 → NP_001120914.1  carboxypeptidase A5 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001120914.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and lacks an exon in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AK131191, BC053681, BK000187
    Consensus CDS
    CCDS47713.1
    UniProtKB/Swiss-Prot
    Q8WXQ8
    Related
    ENSP00000393045.2, ENST00000431780.6
    Conserved Domains (2) summary
    pfam02244
    Location:44 → 116
    Propep_M14; Carboxypeptidase activation peptide
    cl11393
    Location:134 → 380
    Peptidase_M14_like; M14 family of metallocarboxypeptidases and related proteins

  3. NM_001318223.2 → NP_001305152.1  carboxypeptidase A5 isoform 1 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 4 encode the same isoform (1).
    Source sequence(s)
    AK315256, BC053681, BK000187
    Consensus CDS
    CCDS5819.1
    UniProtKB/Swiss-Prot
    G3V0G8, Q6ZNI6, Q86SE2, Q86XM3, Q8NA08, Q8WXQ8
    UniProtKB/TrEMBL
    A4D1M2, B2RCS8
    Related
    ENSP00000418183.1, ENST00000461828.5
    Conserved Domains (2) summary
    cd03870
    Location:134 → 434
    M14_CPA; Peptidase M14 carboxypeptidase subfamily A/B-like; Carboxypeptidase A subgroup
    pfam02244
    Location:48 → 117
    Propep_M14; Carboxypeptidase activation peptide

  4. NM_080385.5 → NP_525124.3  carboxypeptidase A5 isoform 1 precursor

    See identical proteins and their annotated locations for NP_525124.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform (1). Variants 1, 2, and 4 encode the same isoform.
    Source sequence(s)
    BC053681, BK000187
    Consensus CDS
    CCDS5819.1
    UniProtKB/Swiss-Prot
    G3V0G8, Q6ZNI6, Q86SE2, Q86XM3, Q8NA08, Q8WXQ8
    UniProtKB/TrEMBL
    A4D1M2, B2RCS8
    Related
    ENSP00000417314.1, ENST00000474905.6
    Conserved Domains (2) summary
    cd03870
    Location:134 → 434
    M14_CPA; Peptidase M14 carboxypeptidase subfamily A/B-like; Carboxypeptidase A subgroup
    pfam02244
    Location:48 → 117
    Propep_M14; Carboxypeptidase activation peptide

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    130344816..130374599
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047421035.1 → XP_047276991.1  carboxypeptidase A5 isoform X1

    UniProtKB/Swiss-Prot
    G3V0G8, Q6ZNI6, Q86SE2, Q86XM3, Q8NA08, Q8WXQ8
    UniProtKB/TrEMBL
    A4D1M2

  2. XM_047421036.1 → XP_047276992.1  carboxypeptidase A5 isoform X1

    UniProtKB/Swiss-Prot
    G3V0G8, Q6ZNI6, Q86SE2, Q86XM3, Q8NA08, Q8WXQ8
    UniProtKB/TrEMBL
    A4D1M2

  3. XM_024447000.2 → XP_024302768.1  carboxypeptidase A5 isoform X1

    UniProtKB/Swiss-Prot
    G3V0G8, Q6ZNI6, Q86SE2, Q86XM3, Q8NA08, Q8WXQ8
    UniProtKB/TrEMBL
    A4D1M2, B2RCS8
    Conserved Domains (2) summary
    cd03870
    Location:134 → 434
    M14_CPA; Peptidase M14 carboxypeptidase subfamily A/B-like; Carboxypeptidase A subgroup
    pfam02244
    Location:48 → 117
    Propep_M14; Carboxypeptidase activation peptide

  4. XM_047421037.1 → XP_047276993.1  carboxypeptidase A5 isoform X1

    UniProtKB/Swiss-Prot
    G3V0G8, Q6ZNI6, Q86SE2, Q86XM3, Q8NA08, Q8WXQ8
    UniProtKB/TrEMBL
    A4D1M2

  5. XM_024446999.2 → XP_024302767.1  carboxypeptidase A5 isoform X1

    UniProtKB/Swiss-Prot
    G3V0G8, Q6ZNI6, Q86SE2, Q86XM3, Q8NA08, Q8WXQ8
    UniProtKB/TrEMBL
    A4D1M2, B2RCS8
    Related
    ENSP00000419025.2, ENST00000466363.6
    Conserved Domains (2) summary
    cd03870
    Location:134 → 434
    M14_CPA; Peptidase M14 carboxypeptidase subfamily A/B-like; Carboxypeptidase A subgroup
    pfam02244
    Location:48 → 117
    Propep_M14; Carboxypeptidase activation peptide

  6. XM_047421038.1 → XP_047276994.1  carboxypeptidase A5 isoform X2

  7. XM_005250710.2 → XP_005250767.1  carboxypeptidase A5 isoform X1

    See identical proteins and their annotated locations for XP_005250767.1

    UniProtKB/Swiss-Prot
    G3V0G8, Q6ZNI6, Q86SE2, Q86XM3, Q8NA08, Q8WXQ8
    UniProtKB/TrEMBL
    A4D1M2, B2RCS8
    Conserved Domains (2) summary
    cd03870
    Location:134 → 434
    M14_CPA; Peptidase M14 carboxypeptidase subfamily A/B-like; Carboxypeptidase A subgroup
    pfam02244
    Location:48 → 117
    Propep_M14; Carboxypeptidase activation peptide

  8. XM_005250712.2 → XP_005250769.1  carboxypeptidase A5 isoform X1

    See identical proteins and their annotated locations for XP_005250769.1

    UniProtKB/Swiss-Prot
    G3V0G8, Q6ZNI6, Q86SE2, Q86XM3, Q8NA08, Q8WXQ8
    UniProtKB/TrEMBL
    A4D1M2, B2RCS8
    Conserved Domains (2) summary
    cd03870
    Location:134 → 434
    M14_CPA; Peptidase M14 carboxypeptidase subfamily A/B-like; Carboxypeptidase A subgroup
    pfam02244
    Location:48 → 117
    Propep_M14; Carboxypeptidase activation peptide

  9. XM_024447001.2 → XP_024302769.1  carboxypeptidase A5 isoform X1

    UniProtKB/Swiss-Prot
    G3V0G8, Q6ZNI6, Q86SE2, Q86XM3, Q8NA08, Q8WXQ8
    UniProtKB/TrEMBL
    A4D1M2, B2RCS8
    Conserved Domains (2) summary
    cd03870
    Location:134 → 434
    M14_CPA; Peptidase M14 carboxypeptidase subfamily A/B-like; Carboxypeptidase A subgroup
    pfam02244
    Location:48 → 117
    Propep_M14; Carboxypeptidase activation peptide

  10. XM_047421039.1 → XP_047276995.1  carboxypeptidase A5 isoform X3

  11. XM_011516703.2 → XP_011515005.1  carboxypeptidase A5 isoform X1

    See identical proteins and their annotated locations for XP_011515005.1

    UniProtKB/Swiss-Prot
    G3V0G8, Q6ZNI6, Q86SE2, Q86XM3, Q8NA08, Q8WXQ8
    UniProtKB/TrEMBL
    A4D1M2, B2RCS8
    Related
    ENSP00000376907.3, ENST00000393213.7
    Conserved Domains (2) summary
    cd03870
    Location:134 → 434
    M14_CPA; Peptidase M14 carboxypeptidase subfamily A/B-like; Carboxypeptidase A subgroup
    pfam02244
    Location:48 → 117
    Propep_M14; Carboxypeptidase activation peptide

  12. XM_011516698.2 → XP_011515000.1  carboxypeptidase A5 isoform X1

    See identical proteins and their annotated locations for XP_011515000.1

    UniProtKB/Swiss-Prot
    G3V0G8, Q6ZNI6, Q86SE2, Q86XM3, Q8NA08, Q8WXQ8
    UniProtKB/TrEMBL
    A4D1M2, B2RCS8
    Related
    ENSP00000420237.1, ENST00000485477.5
    Conserved Domains (2) summary
    cd03870
    Location:134 → 434
    M14_CPA; Peptidase M14 carboxypeptidase subfamily A/B-like; Carboxypeptidase A subgroup
    pfam02244
    Location:48 → 117
    Propep_M14; Carboxypeptidase activation peptide

RNA

  1. XR_007060171.1 RNA Sequence

  2. XR_007060172.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    131658548..131682444
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054359349.1 → XP_054215324.1  carboxypeptidase A5 isoform X1

  2. XM_054359352.1 → XP_054215327.1  carboxypeptidase A5 isoform X1

  3. XM_054359353.1 → XP_054215328.1  carboxypeptidase A5 isoform X1

  4. XM_054359356.1 → XP_054215331.1  carboxypeptidase A5 isoform X1

  5. XM_054359350.1 → XP_054215325.1  carboxypeptidase A5 isoform X1

  6. XM_054359347.1 → XP_054215322.1  carboxypeptidase A5 isoform X1

  7. XM_054359357.1 → XP_054215332.1  carboxypeptidase A5 isoform X2

  8. XM_054359351.1 → XP_054215326.1  carboxypeptidase A5 isoform X1

  9. XM_054359354.1 → XP_054215329.1  carboxypeptidase A5 isoform X1

  10. XM_054359358.1 → XP_054215333.1  carboxypeptidase A5 isoform X3

  11. XM_054359355.1 → XP_054215330.1  carboxypeptidase A5 isoform X1

  12. XM_054359348.1 → XP_054215323.1  carboxypeptidase A5 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8WXQ8.1 GenPept UniProtKB/Swiss-Prot:Q8WXQ8

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