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Pnck pregnancy upregulated non-ubiquitously expressed CaM kinase [ Mus musculus (house mouse) ]

Gene ID: 93843, updated on 14-Nov-2024

Summary

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Official Symbol
Pnckprovided by MGI
Official Full Name
pregnancy upregulated non-ubiquitously expressed CaM kinaseprovided by MGI
Primary source
MGI:MGI:1347357
See related
Ensembl:ENSMUSG00000002012 AllianceGenome:MGI:1347357
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Punc; Bstk3; Camk1b; CaMKlb2; caMKlb1; CaMKIbeta2
Summary
Predicted to enable calcium/calmodulin-dependent protein kinase activity and calmodulin binding activity. Predicted to be involved in signal transduction. Predicted to be located in nucleus. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human PNCK (pregnancy up-regulated nonubiquitous CaM kinase). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in CNS E18 (RPKM 58.1), bladder adult (RPKM 49.0) and 15 other tissues See more
Orthologs
human all
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Genomic context

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See Pnck in Genome Data Viewer
Location:
X A7.3; X 37.38 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (72699598..72703723, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (73655992..73660117, complement)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_47347 Neighboring gene dual specificity phosphatase 9 Neighboring gene predicted gene, 52444 Neighboring gene STARR-seq mESC enhancer starr_47348 Neighboring gene predicted gene, 32261 Neighboring gene solute carrier family 6 (neurotransmitter transporter, creatine), member 8 Neighboring gene STARR-seq mESC enhancer starr_47349 Neighboring gene B cell receptor associated protein 31 Neighboring gene STARR-positive B cell enhancer ABC_E11048 Neighboring gene ATP-binding cassette, sub-family D member 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Distribution and intracellular localization of a mouse homologue of Ca2+/calmodulin-dependent protein kinase Ibeta2 in the nervous system. Ueda T, et al. J Neurochem, 1999 Nov. PMID 10537072
  2. Mammary gland development, reproductive history, and breast cancer risk. Chodosh LA, et al. Cancer Res, 1999 Apr 1. PMID 10197594
  3. Cloning, characterization, and chromosomal localization of Pnck, a Ca(2+)/calmodulin-dependent protein kinase. Gardner HP, et al. Genomics, 2000 Jan 15. PMID 10673339
  4. Spatiotemporal expression of four isoforms of Ca2+/calmodulin-dependent protein kinase I in brain and its possible roles in hippocampal dendritic growth. Kamata A, et al. Neurosci Res, 2007 Jan. PMID 17056143
  5. Pax1 and Pax9 synergistically regulate vertebral column development. Peters H, et al. Development, 1999 Dec. PMID 10556064

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables calcium/calmodulin-dependent protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium/calmodulin-dependent protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables calcium/calmodulin-dependent protein kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables calmodulin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
calcium/calmodulin-dependent protein kinase type 1B
Names
caM kinase I beta
caM kinase IB
caM-KI beta
caMKI-beta
calcium/calmodulin-dependent protein kinase 1, beta
pregnancy up-regulated non-ubiquitously-expressed CaM kinase homolog
NP_001186280.1
NP_001186281.1
NP_036170.1
XP_006528407.1
XP_011245994.1
XP_030107390.1
XP_030107391.1
XP_036018022.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001199351.1 → NP_001186280.1  calcium/calmodulin-dependent protein kinase type 1B

    See identical proteins and their annotated locations for NP_001186280.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, and 3 encode the same protein.
    Source sequence(s)
    AF181984, AK134665, CD776443, CX243772
    Consensus CDS
    CCDS30207.1
    UniProtKB/Swiss-Prot
    Q80W07, Q9QYK9
    UniProtKB/TrEMBL
    Q3TYC1, Q3UYI0
    Related
    ENSMUSP00000110117.2, ENSMUST00000114473.8
    Conserved Domains (1) summary
    cd14169
    Location:11 → 287
    STKc_CaMKI_beta; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I beta

  2. NM_001199352.1 → NP_001186281.1  calcium/calmodulin-dependent protein kinase type 1B

    See identical proteins and their annotated locations for NP_001186281.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains a different alternate exon in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same protein.
    Source sequence(s)
    AK158755, BC051996, CD776443
    Consensus CDS
    CCDS30207.1
    UniProtKB/Swiss-Prot
    Q80W07, Q9QYK9
    UniProtKB/TrEMBL
    Q3TYC1, Q3UYI0
    Related
    ENSMUSP00000110116.2, ENSMUST00000114472.8
    Conserved Domains (1) summary
    cd14169
    Location:11 → 287
    STKc_CaMKI_beta; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I beta

  3. NM_012040.3 → NP_036170.1  calcium/calmodulin-dependent protein kinase type 1B

    See identical proteins and their annotated locations for NP_036170.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses a different splice site in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same protein.
    Source sequence(s)
    AF181984, CD776443, CX243772
    Consensus CDS
    CCDS30207.1
    UniProtKB/Swiss-Prot
    Q80W07, Q9QYK9
    UniProtKB/TrEMBL
    Q3TYC1, Q3UYI0
    Related
    ENSMUSP00000002087.8, ENSMUST00000002087.14
    Conserved Domains (1) summary
    cd14169
    Location:11 → 287
    STKc_CaMKI_beta; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I beta

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    72699598..72703723 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011247692.3 → XP_011245994.1  calcium/calmodulin-dependent protein kinase type 1B isoform X1

    See identical proteins and their annotated locations for XP_011245994.1

    UniProtKB/Swiss-Prot
    Q80W07, Q9QYK9
    UniProtKB/TrEMBL
    Q3TYC1, Q3UYI0
    Conserved Domains (1) summary
    cd14169
    Location:11 → 287
    STKc_CaMKI_beta; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I beta

  2. XM_036162129.1 → XP_036018022.1  calcium/calmodulin-dependent protein kinase type 1B isoform X2

    UniProtKB/TrEMBL
    Q3UYI0
    Conserved Domains (1) summary
    cl21453
    Location:2 → 258
    PKc_like; Protein Kinases, catalytic domain

  3. XM_030251530.2 → XP_030107390.1  calcium/calmodulin-dependent protein kinase type 1B isoform X1

    UniProtKB/Swiss-Prot
    Q80W07, Q9QYK9
    UniProtKB/TrEMBL
    Q3TYC1, Q3UYI0
    Conserved Domains (1) summary
    cd14169
    Location:11 → 287
    STKc_CaMKI_beta; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I beta

  4. XM_006528344.5 → XP_006528407.1  calcium/calmodulin-dependent protein kinase type 1B isoform X1

    See identical proteins and their annotated locations for XP_006528407.1

    UniProtKB/Swiss-Prot
    Q80W07, Q9QYK9
    UniProtKB/TrEMBL
    Q3TYC1, Q3UYI0
    Conserved Domains (1) summary
    cd14169
    Location:11 → 287
    STKc_CaMKI_beta; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I beta

  5. XM_030251531.1 → XP_030107391.1  calcium/calmodulin-dependent protein kinase type 1B isoform X1

    UniProtKB/Swiss-Prot
    Q80W07, Q9QYK9
    UniProtKB/TrEMBL
    Q3TYC1, Q3UYI0
    Conserved Domains (1) summary
    cd14169
    Location:11 → 287
    STKc_CaMKI_beta; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I beta

RNA

  1. XR_003953034.1 RNA Sequence

  2. XR_001782761.2 RNA Sequence

  3. XR_003953032.1 RNA Sequence

  4. XR_003953033.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9QYK9.1 GenPept UniProtKB/Swiss-Prot:Q9QYK9

Gene LinkOut

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