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pucM 5-hydroxyisourate hydrolase; also uricase subunit [ Bacillus subtilis subsp. subtilis str. 168 ]

Gene ID: 937977, updated on 4-Apr-2024

Summary

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Gene symbol
pucM
Gene description
5-hydroxyisourate hydrolase; also uricase subunit
Locus tag
BSU_32460
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bacillus subtilis subsp. subtilis str. 168 (strain: 168, sub-species: subtilis, type-material: type strain of Bacillus subtilis)
Lineage
Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus
Old locus tag
BSU32460
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Genomic context

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Sequence:
NC_000964.3 (3334646..3334990)

NC_000964.3Genomic Context describing neighboring genes Neighboring gene uric acid permease subunit Neighboring gene urate oxidase with peroxide reductase N-terminal domain Neighboring gene putative type I toxin Neighboring gene ncRNA Neighboring gene xanthine dehydrogenase, iron-sulfur subunit Neighboring gene xanthine dehydrogenase, substrate and molybdenum cofactor subunit

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000964.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Structural and functional analysis of PucM, a hydrolase in the ureide pathway and a member of the transthyretin-related protein family. Jung DK, et al. Proc Natl Acad Sci U S A, 2006 Jun 27. PMID 16782815, Free PMC Article
  2. Transthyretin-related proteins function to facilitate the hydrolysis of 5-hydroxyisourate, the end product of the uricase reaction. Lee Y, et al. FEBS Lett, 2005 Aug 29. PMID 16098976
  3. Bacillus subtilis, the model Gram-positive bacterium: 20 years of annotation refinement. Borriss R, et al. Microb Biotechnol, 2018 Jan. PMID 29280348, Free PMC Article
  4. An updated metabolic view of the Bacillus subtilis 168 genome. Belda E, et al. Microbiology (Reading), 2013 Apr. PMID 23429746
  5. From a consortium sequence to a unified sequence: the Bacillus subtilis 168 reference genome a decade later. Barbe V, et al. Microbiology (Reading), 2009 Jun. PMID 19383706, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data suggest that PucM, a transthyretin-related protein, functions to facilitate the hydrolysis of 5-hydroxyisourate, the end product of the uricase reaction.
    Title: Transthyretin-related proteins function to facilitate the hydrolysis of 5-hydroxyisourate, the end product of the uricase reaction.
  2. The crystal structures of PucM at 2.0 A and its complexes with the substrate analogs 8-azaxanthine and 5,6-diaminouracil were reported.
    Title: Structural and functional analysis of PucM, a hydrolase in the ureide pathway and a member of the transthyretin-related protein family.
Submit: New GeneRIF Correction

General gene information

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Homology

General protein information

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Preferred Names
5-hydroxyisourate hydrolase; also uricase subunit
NP_391126.2
  • Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 16098976, 16782815, 21795808; Product type e: enzyme

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000964.3 Reference assembly

    Range
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_391126.2 5-hydroxyisourate hydrolase; also uricase subunit [Bacillus subtilis subsp. subtilis str. 168]

    See identical proteins and their annotated locations for NP_391126.2

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    D4G105
    Conserved Domains (1) summary
    COG2351
    Location:1 → 114
    HiuH; 5-hydroxyisourate hydrolase (purine catabolism), transthyretin-related family [Nucleotide transport and metabolism]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O32142.2

Gene LinkOut

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Other Literature Sources
Molecular Biology Databases