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abrB transcriptional regulator for transition state genes (AbrB-SurF) [ Bacillus subtilis subsp. subtilis str. 168 ]

Gene ID: 937009, updated on 6-Oct-2023

Summary

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Gene symbol
abrB
Gene description
transcriptional regulator for transition state genes (AbrB-SurF)
Locus tag
BSU_00370
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bacillus subtilis subsp. subtilis str. 168 (strain: 168, sub-species: subtilis, type-material: type strain of Bacillus subtilis)
Lineage
Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus
Old locus tag
BSU00370
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Genomic context

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Sequence:
NC_000964.3 (44848..45138, complement)

NC_000964.3Genomic Context describing neighboring genes Neighboring gene tRNA1(Val) (adenine(37)-N6)-methyltransferase Neighboring gene putative UvrC-Intron-type (URI) endonuclease Neighboring gene 16S rRNA 2'-O-ribose C1402 methyltransferase Neighboring gene methionyl-tRNA synthetase Neighboring gene D-amino acyl-tRNA deacylase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000964.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. SMTracker: a tool for quantitative analysis, exploration and visualization of single-molecule tracking data reveals highly dynamic binding of B. subtilis global repressor AbrB throughout the genome. Rösch TC, et al. Sci Rep, 2018 Oct 24. PMID 30356068, Free PMC Article
  2. Small regulatory RNA-induced growth rate heterogeneity of Bacillus subtilis. Mars RA, et al. PLoS Genet, 2015 Mar. PMID 25790031, Free PMC Article
  3. Chemical crosslinking and LC/MS analysis to determine protein domain orientation: application to AbrB. Olson AL, et al. Biochem Biophys Res Commun, 2013 Feb 8. PMID 23313475, Free PMC Article
  4. ScoC regulates bacilysin production at the transcription level in Bacillus subtilis. Inaoka T, et al. J Bacteriol, 2009 Dec. PMID 19801406, Free PMC Article
  5. Abh and AbrB control of Bacillus subtilis antimicrobial gene expression. Strauch MA, et al. J Bacteriol, 2007 Nov. PMID 17720793, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. the global transcriptional repressor AbrB performs highly dynamic binding throughout the Bacillus subtilis genome, with short dwell times that indicate high on/off rates in vivo
    Title: SMTracker: a tool for quantitative analysis, exploration and visualization of single-molecule tracking data reveals highly dynamic binding of B. subtilis global repressor AbrB throughout the genome.
  2. we show that the sRNA-induced diversity in AbrB levels generates heterogeneity in growth rates during the exponential growth phase
    Title: Small regulatory RNA-induced growth rate heterogeneity of Bacillus subtilis.
  3. C-termini are responsible for the cooperative character observed for AbrB interaction with some DNA targets like tycA and phyC
    Title: Substitutional analysis of the C-terminal domain of AbrB revealed its essential role in DNA-binding activity.
  4. this study solved the NMR structures of both domains independently and utilized gas-phase cleavable chemical crosslinking and LC/MS(n) analysis to correctly position the domains within the full tetrameric AbrB protein structure.
    Title: Chemical crosslinking and LC/MS analysis to determine protein domain orientation: application to AbrB.
  5. A report on the in vivo distribution over the entire B. subtilis genome of AbrB-binding sites during exponential growth phase when AbrB principally functions.
    Title: Genome-wide binding profiles of the Bacillus subtilis transition state regulator AbrB and its homolog Abh reveals their interactive role in transcriptional regulation.
  6. Results indicate that the transition state regulator ScoC, together with CodY and AbrB, negatively regulates bacilysin production in B. subtilis. [ScoC]
    Title: ScoC regulates bacilysin production at the transcription level in Bacillus subtilis.
  7. Abh gene, controling AbrB expression is part of the complex interconnected regulatory system that controls gene expression during the transition from active growth to stationary phase.
    Title: Abh and AbrB control of Bacillus subtilis antimicrobial gene expression.
  8. we demonstrate that overproduction of the phosphorelay components KinA and Spo0A stimulates cell bundle formation in biofilms, while overproduction of the transition state regulators AbrB and SinR leads to repression of formation of elevated bundles.
    Title: Effects of phosphorelay perturbations on architecture, sporulation, and spore resistance in biofilms of Bacillus subtilis.
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General gene information

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Homology

General protein information

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Preferred Names
transcriptional regulator for transition state genes (AbrB-SurF)
NP_387918.1
  • Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10754235, 10809710, 11101881, 11101897, 16159768, 16223496, 16702211, 25308864, 25381239, 18676675, 22183144, 23196984, 24832089, 24847778, 25288929; Product type r: regulator

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000964.3 Reference assembly

    Range
    44848..45138 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_387918.1 transcriptional regulator for transition state genes (AbrB-SurF) [Bacillus subtilis subsp. subtilis str. 168]

    See identical proteins and their annotated locations for NP_387918.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A7U5HS29
    Conserved Domains (1) summary
    COG2002
    Location:3 → 92
    AbrB; Bifunctional DNA-binding transcriptional regulator of stationary/sporulation/toxin gene expression and antitoxin component of the YhaV-PrlF toxin-antitoxin module [Transcription, Defense mechanisms]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P08874.1

Gene LinkOut

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Other Literature Sources
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Research Materials