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Csnk1a1 casein kinase 1, alpha 1 [ Mus musculus (house mouse) ]

Gene ID: 93687, updated on 2-Nov-2024

Summary

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Official Symbol
Csnk1a1provided by MGI
Official Full Name
casein kinase 1, alpha 1provided by MGI
Primary source
MGI:MGI:1934950
See related
Ensembl:ENSMUSG00000024576 AllianceGenome:MGI:1934950
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CK1a; Csnk1a; 2610208K14Rik; 4632404G05Rik; 5430427P18Rik
Summary
Enables protein serine/threonine kinase activity. Involved in negative regulation of NLRP3 inflammasome complex assembly and protein phosphorylation. Acts upstream of or within cell morphogenesis. Located in ciliary basal body and spindle. Part of ribonucleoprotein complex. Is expressed in several structures, including central nervous system; endocrine gland; metanephros; retina nuclear layer; and thymus primordium. Orthologous to human CSNK1A1 (casein kinase 1 alpha 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in CNS E14 (RPKM 23.9), bladder adult (RPKM 23.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Csnk1a1 in Genome Data Viewer
Location:
18 E1; 18 34.62 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (61687307..61723391)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (61554236..61590320)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 46637 Neighboring gene Rho guanine nucleotide exchange factor 37 Neighboring gene STARR-seq mESC enhancer starr_44745 Neighboring gene STARR-seq mESC enhancer starr_44746 Neighboring gene STARR-positive B cell enhancer ABC_E9979 Neighboring gene STARR-seq mESC enhancer starr_44748 Neighboring gene VISTA enhancer mm36 Neighboring gene STARR-seq mESC enhancer starr_44754 Neighboring gene predicted gene, 41747 Neighboring gene STARR-seq mESC enhancer starr_44755 Neighboring gene predicted gene, 35607

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Exploring the role of casein kinase 1α splice variants across cancer cell lines. Meléndez RA, et al. Biochem Biophys Res Commun, 2024 Sep 3. PMID 38852281,
  2. Tissue-specific distribution of mouse casein kinase I alpha mRNA. McInnes C, et al. DNA Seq, 1997. PMID 9522121
  3. Systems biology approach identifies the kinase Csnk1a1 as a regulator of the DNA damage response in embryonic stem cells. Carreras Puigvert J, et al. Sci Signal, 2013 Jan 22. PMID 23354688
  4. Casein kinase 1 alpha regulates chromosome congression and separation during mouse oocyte meiotic maturation and early embryo development. Wang L, et al. PLoS One, 2013. PMID 23690993, Free PMC Article
  5. Csnk1a1 inhibition modulates the inflammatory secretome and enhances response to radiotherapy in glioma. Liu G, et al. J Cell Mol Med, 2021 Aug. PMID 34216174, Free PMC Article

See all (89) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Casein kinase 1alpha mediates estradiol secretion via CYP19A1 expression in mouse ovarian granulosa cells.
    Title: Casein kinase 1α mediates estradiol secretion via CYP19A1 expression in mouse ovarian granulosa cells.
  2. Exploring the role of casein kinase 1alpha splice variants across cancer cell lines.
    Title: Exploring the role of casein kinase 1α splice variants across cancer cell lines.
  3. CK1alpha deficiency impairs mouse uterine adenogenesis by inducing epithelial cell apoptosis through GSK3beta pathway and inhibiting Foxa2 expression through p53 pathwaydagger.
    Title: CK1α deficiency impairs mouse uterine adenogenesis by inducing epithelial cell apoptosis through GSK3β pathway and inhibiting Foxa2 expression through p53 pathway†.
  4. Collaborative effect of Csnk1a1 haploinsufficiency and mutant p53 in Myc induction can promote leukemic transformation.
    Title: Collaborative effect of Csnk1a1 haploinsufficiency and mutant p53 in Myc induction can promote leukemic transformation.
  5. CSNK1A1/CK1alpha suppresses autoimmunity by restraining the CGAS-STING1 signaling.
    Title: CSNK1A1/CK1α suppresses autoimmunity by restraining the CGAS-STING1 signaling.
  6. Casein Kinase 1alpha Regulates Testosterone Synthesis and Testis Development in Adult Mice.
    Title: Casein Kinase 1α Regulates Testosterone Synthesis and Testis Development in Adult Mice.
  7. Glutaredoxin 1 protects lens epithelial cells from epithelial-mesenchymal transition by preventing casein kinase 1alpha S-glutathionylation during posterior capsular opacification.
    Title: Glutaredoxin 1 protects lens epithelial cells from epithelial-mesenchymal transition by preventing casein kinase 1α S-glutathionylation during posterior capsular opacification.
  8. Casein Kinase 1alpha as a Novel Factor Affects Thyrotropin Synthesis via PKC/ERK/CREB Signaling.
    Title: Casein Kinase 1α as a Novel Factor Affects Thyrotropin Synthesis via PKC/ERK/CREB Signaling.
  9. Knockdown of Csnk1a1 results in preimplantation developmental arrest in mice.
    Title: Knockdown of Csnk1a1 results in preimplantation developmental arrest in mice.
  10. Class III beta-Tubulin Expression Is of Value in Selecting nab -Paclitaxel and Gemcitabine as First-Line Therapy in Unresectable Pancreatic Cancer.
    Title: Class III β-Tubulin Expression Is of Value in Selecting nab -Paclitaxel and Gemcitabine as First-Line Therapy in Unresectable Pancreatic Cancer.
Submit: New GeneRIF Correction See all GeneRIFs (27)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Gene trapped (1) 
  • Targeted (4)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC29354, MGC30571

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding ISO
Inferred from Sequence Orthology
more info
  
enables histone H2AS1 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion binding ISO
Inferred from Sequence Orthology
more info
  
enables peptide binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphoprotein binding ISO
Inferred from Sequence Orthology
more info
  
enables protein kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein serine/threonine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
  
Process Evidence Code Pubs
involved_in Golgi organization ISO
Inferred from Sequence Orthology
more info
  
involved_in Golgi organization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell morphogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in cellular response to nutrient ISO
Inferred from Sequence Orthology
more info
  
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in intermediate filament cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
involved_in intermediate filament cytoskeleton organization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of NLRP3 inflammasome complex assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in peptidyl-serine phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of Rho protein signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of TORC1 signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in protein phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of beta-catenin destruction complex ISO
Inferred from Sequence Orthology
more info
  
part_of beta-catenin destruction complex ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of beta-catenin destruction complex NAS
Non-traceable Author Statement
more info
 PubMed 
located_in centrosome IEA
Inferred from Electronic Annotation
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in ciliary basal body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cilium TAS
Traceable Author Statement
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
colocalizes_with keratin filament ISO
Inferred from Sequence Orthology
more info
  
colocalizes_with keratin filament ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in kinetochore IEA
Inferred from Electronic Annotation
more info
  
part_of mRNA cleavage and polyadenylation specificity factor complex ISO
Inferred from Sequence Orthology
more info
  
part_of mRNA cleavage and polyadenylation specificity factor complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear speck ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ribonucleoprotein complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in spindle IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
casein kinase I isoform alpha; casein kinase I
Names
CK1
CKI-alpha
casein kinase I-alpha
NP_001344427.1
NP_001344428.1
NP_001344429.1
NP_666199.1
XP_006526446.1
XP_006526449.1
XP_011245350.1
XP_030106505.1
XP_030106506.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357498.1 → NP_001344427.1  casein kinase I isoform alpha isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC153155, AI853067
    Consensus CDS
    CCDS89252.1
    UniProtKB/TrEMBL
    E9Q3W1, Q3U772
    Related
    ENSMUSP00000127265.2, ENSMUST00000170862.8
    Conserved Domains (1) summary
    cd14128
    Location:16 → 309
    STKc_CK1_alpha; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 alpha

  2. NM_001357499.1 → NP_001344428.1  casein kinase I isoform alpha isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC153155, AI853067
    Consensus CDS
    CCDS89251.1
    UniProtKB/TrEMBL
    E9Q2U6, Q3U844
    Related
    ENSMUSP00000127463.2, ENSMUST00000167187.8
    Conserved Domains (1) summary
    cd14128
    Location:16 → 309
    STKc_CK1_alpha; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 alpha

  3. NM_001357500.1 → NP_001344429.1  casein kinase I isoform alpha isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC153155, AI853067
    Consensus CDS
    CCDS89254.1
    UniProtKB/Swiss-Prot
    Q3UIL0, Q64506, Q80XI2, Q8BK63, Q99LY3
    UniProtKB/TrEMBL
    Q3U772
    Related
    ENSMUSP00000132083.2, ENSMUST00000165721.8
    Conserved Domains (1) summary
    cd14128
    Location:16 → 281
    STKc_CK1_alpha; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 alpha

  4. NM_146087.3 → NP_666199.1  casein kinase I isoform alpha isoform 1

    See identical proteins and their annotated locations for NP_666199.1

    Status: VALIDATED

    Source sequence(s)
    AC153155, AI853067, AK076070, AK146873, BY065893
    Consensus CDS
    CCDS37838.1
    UniProtKB/TrEMBL
    Q3U844, Q6PJ87
    Related
    ENSMUSP00000128871.2, ENSMUST00000165123.8
    Conserved Domains (1) summary
    cd14128
    Location:16 → 281
    STKc_CK1_alpha; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 alpha

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    61687307..61723391
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011247048.3 → XP_011245350.1  casein kinase I isoform X1

    UniProtKB/TrEMBL
    Q3U772
    Conserved Domains (1) summary
    cd14128
    Location:16 → 309
    STKc_CK1_alpha; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 alpha

  2. XM_006526383.4 → XP_006526446.1  casein kinase I isoform X2

    UniProtKB/TrEMBL
    Q3U772
    Conserved Domains (1) summary
    cd14128
    Location:16 → 309
    STKc_CK1_alpha; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 alpha

  3. XM_006526386.4 → XP_006526449.1  casein kinase I isoform X3

    UniProtKB/TrEMBL
    Q3U844
    Conserved Domains (1) summary
    cd14128
    Location:16 → 309
    STKc_CK1_alpha; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 alpha

  4. XM_030250645.1 → XP_030106505.1  casein kinase I isoform X4

    UniProtKB/TrEMBL
    Q3U772
    Related
    ENSMUSP00000127144.2, ENSMUST00000163205.8
    Conserved Domains (1) summary
    cd14128
    Location:16 → 281
    STKc_CK1_alpha; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 alpha

  5. XM_030250646.1 → XP_030106506.1  casein kinase I isoform X5

    UniProtKB/TrEMBL
    H7BXB1, Q3U844
    Related
    ENSMUSP00000110901.3, ENSMUST00000115246.9
    Conserved Domains (1) summary
    cd14128
    Location:16 → 281
    STKc_CK1_alpha; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 alpha

RNA

  1. XR_386022.4 RNA Sequence

  2. XR_386023.4 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BK63.2 GenPept UniProtKB/Swiss-Prot:Q8BK63

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
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