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Sec31a SEC31 homolog A, COPII coat complex component [ Rattus norvegicus (Norway rat) ]

Gene ID: 93646, updated on 2-Nov-2024

Summary

Official Symbol
Sec31aprovided by RGD
Official Full Name
SEC31 homolog A, COPII coat complex componentprovided by RGD
Primary source
RGD:620233
See related
EnsemblRapid:ENSRNOG00000002251 AllianceGenome:RGD:620233
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
VAP1; Sec31l1
Summary
Predicted to enable calcium-dependent protein binding activity and structural molecule activity. Predicted to be involved in COPII-coated vesicle cargo loading; endoplasmic reticulum organization; and response to calcium ion. Located in endosome. Human ortholog(s) of this gene implicated in Halperin-Birk syndrome. Orthologous to human SEC31A (SEC31 homolog A, COPII coat complex component). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 158.6), Adrenal (RPKM 139.7) and 9 other tissues See more
Orthologs
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Genomic context

See Sec31a in Genome Data Viewer
Location:
14p22
Exon count:
30
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (9518655..9573579)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (9214324..9269281)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (10854713..10909579)

Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102550950 Neighboring gene lin-54 DREAM MuvB core complex component Neighboring gene transfer RNA serine (anticodon AGA) 37 Neighboring gene uncharacterized LOC102551078

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC93320

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables calcium-dependent protein binding IEA
Inferred from Electronic Annotation
more info
 
enables calcium-dependent protein binding ISO
Inferred from Sequence Orthology
more info
 
enables structural molecule activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in COPII-coated vesicle cargo loading IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in COPII-coated vesicle cargo loading IEA
Inferred from Electronic Annotation
more info
 
involved_in COPII-coated vesicle cargo loading ISO
Inferred from Sequence Orthology
more info
 
involved_in endoplasmic reticulum organization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
 
involved_in response to calcium ion IEA
Inferred from Electronic Annotation
more info
 
involved_in response to calcium ion ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of COPII vesicle coat IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of COPII vesicle coat IEA
Inferred from Electronic Annotation
more info
 
part_of COPII vesicle coat ISO
Inferred from Sequence Orthology
more info
 
part_of COPII vesicle coat ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in COPII-coated ER to Golgi transport vesicle ISO
Inferred from Sequence Orthology
more info
 
located_in COPII-coated ER to Golgi transport vesicle ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
is_active_in endoplasmic reticulum exit site IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in endoplasmic reticulum exit site IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum exit site ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum exit site ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
located_in endosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
part_of vesicle coat ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
protein transport protein Sec31A
Names
SEC31 homolog A, COPII coating complex component
SEC31-like 1
SEC31-like protein 1
SEC31-related protein A
vesicle associated protein
vesicle-associated protein 1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_033021.2NP_148981.2  protein transport protein Sec31A

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000014
    UniProtKB/Swiss-Prot
    Q5RKK4, Q9Z2Q1
    UniProtKB/TrEMBL
    A6K602, G3V699
    Related
    ENSRNOP00000003072.3, ENSRNOT00000003072.7
    Conserved Domains (4) summary
    PHA03247
    Location:7951146
    PHA03247; large tegument protein UL36; Provisional
    sd00039
    Location:1365
    7WD40; WD40 repeat [structural motif]
    cl14807
    Location:573767
    ACE1-Sec16-like; Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16
    cl29593
    Location:84340
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086032.1 Reference GRCr8

    Range
    9518655..9573579
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063273705.1XP_063129775.1  protein transport protein Sec31A isoform X14

  2. XM_063273710.1XP_063129780.1  protein transport protein Sec31A isoform X18

  3. XM_006250677.4XP_006250739.1  protein transport protein Sec31A isoform X1

    See identical proteins and their annotated locations for XP_006250739.1

    UniProtKB/Swiss-Prot
    Q5RKK4, Q9Z2Q1
    Conserved Domains (4) summary
    COG2319
    Location:31405
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:1365
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:84340
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    cl14807
    Location:573767
    ACE1-Sec16-like; Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16
  4. XM_063273696.1XP_063129766.1  protein transport protein Sec31A isoform X5

    UniProtKB/TrEMBL
    A0A0G2K0X9, A6K603
  5. XM_063273698.1XP_063129768.1  protein transport protein Sec31A isoform X8

  6. XM_063273704.1XP_063129774.1  protein transport protein Sec31A isoform X13

  7. XM_063273714.1XP_063129784.1  protein transport protein Sec31A isoform X23

    UniProtKB/TrEMBL
    A0A8L2QIX3
  8. XM_063273703.1XP_063129773.1  protein transport protein Sec31A isoform X12

  9. XM_063273707.1XP_063129777.1  protein transport protein Sec31A isoform X15

    UniProtKB/TrEMBL
    A0A8I5ZP55, A6K604
  10. XM_063273711.1XP_063129781.1  protein transport protein Sec31A isoform X19

  11. XM_063273713.1XP_063129783.1  protein transport protein Sec31A isoform X21

  12. XM_006250690.4XP_006250752.1  protein transport protein Sec31A isoform X26

    See identical proteins and their annotated locations for XP_006250752.1

    UniProtKB/Swiss-Prot
    Q5RKK4, Q9Z2Q1
    Conserved Domains (4) summary
    COG2319
    Location:31405
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:1365
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:84340
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    cl14807
    Location:534728
    ACE1-Sec16-like; Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16
  13. XM_063273700.1XP_063129770.1  protein transport protein Sec31A isoform X10

  14. XM_006250678.5XP_006250740.1  protein transport protein Sec31A isoform X2

    UniProtKB/Swiss-Prot
    Q5RKK4, Q9Z2Q1
    Conserved Domains (4) summary
    COG2319
    Location:31405
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:1365
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:84340
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    cl14807
    Location:573767
    ACE1-Sec16-like; Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16
  15. XM_006250680.5XP_006250742.1  protein transport protein Sec31A isoform X4

    UniProtKB/Swiss-Prot
    Q5RKK4, Q9Z2Q1
    Conserved Domains (4) summary
    COG2319
    Location:31405
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:1365
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:84340
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    cl14807
    Location:573767
    ACE1-Sec16-like; Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16
  16. XM_006250687.5XP_006250749.1  protein transport protein Sec31A isoform X22

    UniProtKB/Swiss-Prot
    Q5RKK4, Q9Z2Q1
    Conserved Domains (4) summary
    COG2319
    Location:31405
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:1365
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:84340
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    cl14807
    Location:573767
    ACE1-Sec16-like; Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16
  17. XM_006250681.5XP_006250743.1  protein transport protein Sec31A isoform X5

    See identical proteins and their annotated locations for XP_006250743.1

    UniProtKB/Swiss-Prot
    Q5RKK4, Q9Z2Q1
    UniProtKB/TrEMBL
    A0A0G2K0X9, A6K603
    Related
    ENSRNOP00000071621.2, ENSRNOT00000091367.3
    Conserved Domains (4) summary
    COG2319
    Location:31405
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:1365
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:84340
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    cl14807
    Location:573767
    ACE1-Sec16-like; Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16
  18. XM_006250683.5XP_006250745.1  protein transport protein Sec31A isoform X8

    UniProtKB/Swiss-Prot
    Q5RKK4, Q9Z2Q1
    Related
    ENSRNOP00000038196.6, ENSRNOT00000033489.7
    Conserved Domains (4) summary
    COG2319
    Location:31405
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:1365
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:84340
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    cl14807
    Location:573767
    ACE1-Sec16-like; Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16
  19. XM_063273699.1XP_063129769.1  protein transport protein Sec31A isoform X9

  20. XM_006250684.5XP_006250746.1  protein transport protein Sec31A isoform X13

    UniProtKB/Swiss-Prot
    Q5RKK4, Q9Z2Q1
    Conserved Domains (4) summary
    COG2319
    Location:31405
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:1365
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:84340
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    cl14807
    Location:573767
    ACE1-Sec16-like; Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16
  21. XM_006250688.5XP_006250750.1  protein transport protein Sec31A isoform X23

    UniProtKB/Swiss-Prot
    Q5RKK4, Q9Z2Q1
    UniProtKB/TrEMBL
    A0A8L2QIX3
    Related
    ENSRNOP00000109931.1, ENSRNOT00000153513.1
    Conserved Domains (4) summary
    COG2319
    Location:31405
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:1365
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:84340
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    cl14807
    Location:573767
    ACE1-Sec16-like; Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16
  22. XM_006250679.5XP_006250741.1  protein transport protein Sec31A isoform X3

    UniProtKB/Swiss-Prot
    Q5RKK4, Q9Z2Q1
    Conserved Domains (4) summary
    COG2319
    Location:31405
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:1365
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:84340
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    cl14807
    Location:547741
    ACE1-Sec16-like; Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16
  23. XM_063273697.1XP_063129767.1  protein transport protein Sec31A isoform X6

  24. XM_063273702.1XP_063129772.1  protein transport protein Sec31A isoform X12

    Related
    ENSRNOP00000079808.2, ENSRNOT00000097169.2
  25. XM_063273706.1XP_063129776.1  protein transport protein Sec31A isoform X15

    UniProtKB/TrEMBL
    A0A8I5ZP55, A6K604
  26. XM_063273709.1XP_063129779.1  protein transport protein Sec31A isoform X17

  27. XM_063273712.1XP_063129782.1  protein transport protein Sec31A isoform X20

  28. XM_039092523.2XP_038948451.1  protein transport protein Sec31A isoform X25

    UniProtKB/Swiss-Prot
    Q5RKK4, Q9Z2Q1
    Conserved Domains (3) summary
    sd00039
    Location:1365
    7WD40; WD40 repeat [structural motif]
    cl14807
    Location:547741
    ACE1-Sec16-like; Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16
    cl29593
    Location:84340
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  29. XM_006250682.5XP_006250744.1  protein transport protein Sec31A isoform X7

    UniProtKB/Swiss-Prot
    Q5RKK4, Q9Z2Q1
    Conserved Domains (4) summary
    COG2319
    Location:31405
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:1365
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:84340
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    cl14807
    Location:534728
    ACE1-Sec16-like; Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16
  30. XM_063273701.1XP_063129771.1  protein transport protein Sec31A isoform X11

  31. XM_063273715.1XP_063129785.1  protein transport protein Sec31A isoform X24

  32. XM_063273708.1XP_063129778.1  protein transport protein Sec31A isoform X16

    UniProtKB/TrEMBL
    A0A8I6GED0
    Related
    ENSRNOP00000085826.1, ENSRNOT00000116260.2
  33. XM_006250685.5XP_006250747.1  protein transport protein Sec31A isoform X19

    UniProtKB/Swiss-Prot
    Q5RKK4, Q9Z2Q1
    Conserved Domains (4) summary
    COG2319
    Location:31405
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:1365
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:84340
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    cl14807
    Location:534728
    ACE1-Sec16-like; Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16
  34. XM_006250686.5XP_006250748.1  protein transport protein Sec31A isoform X21

    UniProtKB/Swiss-Prot
    Q5RKK4, Q9Z2Q1
    Conserved Domains (4) summary
    COG2319
    Location:31405
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:1365
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:84340
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    cl14807
    Location:534728
    ACE1-Sec16-like; Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16
  35. XM_006250689.5XP_006250751.1  protein transport protein Sec31A isoform X26

    See identical proteins and their annotated locations for XP_006250751.1

    UniProtKB/Swiss-Prot
    Q5RKK4, Q9Z2Q1
    Conserved Domains (4) summary
    COG2319
    Location:31405
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:1365
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:84340
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    cl14807
    Location:534728
    ACE1-Sec16-like; Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16