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TJAP1 tight junction associated protein 1 [ Homo sapiens (human) ]

Gene ID: 93643, updated on 3-Apr-2024

Summary

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Official Symbol
TJAP1provided by HGNC
Official Full Name
tight junction associated protein 1provided by HGNC
Primary source
HGNC:HGNC:17949
See related
Ensembl:ENSG00000137221 MIM:612658; AllianceGenome:HGNC:17949
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PILT; TJP4
Summary
This gene encodes a tight junction-associated protein. Incorporation of the encoded protein into tight junctions occurs at a late stage of formation of the junctions. The encoded protein localizes to the Golgi and may function in vesicle trafficking. Alternatively spliced transcript variants have been described. A related pseudogene exists on the X chromosome. [provided by RefSeq, Mar 2009]
Expression
Ubiquitous expression in ovary (RPKM 10.1), endometrium (RPKM 8.8) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
6p21.1
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (43477570..43506554)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (43306318..43335293)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (43445308..43474292)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene ATP binding cassette subfamily C member 10 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24601 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17229 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17230 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17231 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:43423943-43424784 Neighboring gene delta like non-canonical Notch ligand 2 Neighboring gene MPRA-validated peak5814 silencer Neighboring gene RNA, U6 small nuclear 1113, pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:43445658-43446451 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:43457381-43457974 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:43457975-43458569 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17232 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17233 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17234 Neighboring gene leucine rich repeat containing 73 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24602 Neighboring gene Yip1 domain family member 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Pilt, a novel peripheral membrane protein at tight junctions in epithelial cells. Kawabe H, et al. J Biol Chem, 2001 Dec 21. PMID 11602598
  2. Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects. Deng X, et al. PLoS One, 2013. PMID 24324551, Free PMC Article
  3. BioID reveals an ATG9A interaction with ATG13-ATG101 in the degradation of p62/SQSTM1-ubiquitin clusters. Kannangara AR, et al. EMBO Rep, 2021 Oct 5. PMID 34369648, Free PMC Article
  4. LINKIN, a new transmembrane protein necessary for cell adhesion. Kato M, et al. Elife, 2014 Dec 1. PMID 25437307, Free PMC Article
  5. Protein interactome reveals converging molecular pathways among autism disorders. Sakai Y, et al. Sci Transl Med, 2011 Jun 8. PMID 21653829, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • DKFZp686F06131

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in Golgi organization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
  
located_in bicellular tight junction IEA
Inferred from Electronic Annotation
more info
  
located_in endosome IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in trans-Golgi network IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
tight junction-associated protein 1
Names
protein incorporated later into tight junctions
tight junction associated protein 1 (peripheral)
tight junction protein 4 (peripheral)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001146016.2 → NP_001139488.1  tight junction-associated protein 1 isoform a

    See identical proteins and their annotated locations for NP_001139488.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a). Variants 1, 2, and 8-15 all encode the same isoform (a).
    Source sequence(s)
    AK074241, BC046239, DA018836
    Consensus CDS
    CCDS55004.1
    UniProtKB/Swiss-Prot
    Q05BH9, Q5JTD0, Q5JTD1, Q5JWW1, Q68DB2, Q6P2P3, Q9H7V7
    Related
    ENSP00000361522.5, ENST00000372445.9
    Conserved Domains (2) summary
    COG1196
    Location:17 → 163
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam15453
    Location:284 → 556
    Pilt; Protein incorporated later into Tight Junctions

  2. NM_001146017.2 → NP_001139489.1  tight junction-associated protein 1 isoform a

    See identical proteins and their annotated locations for NP_001139489.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 8-15 all encode the same isoform (a).
    Source sequence(s)
    AK074241, DA297698, DA415818
    Consensus CDS
    CCDS55004.1
    UniProtKB/Swiss-Prot
    Q05BH9, Q5JTD0, Q5JTD1, Q5JWW1, Q68DB2, Q6P2P3, Q9H7V7
    Related
    ENSP00000408769.2, ENST00000438588.6
    Conserved Domains (2) summary
    COG1196
    Location:17 → 163
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam15453
    Location:284 → 556
    Pilt; Protein incorporated later into Tight Junctions

  3. NM_001146018.2 → NP_001139490.1  tight junction-associated protein 1 isoform b

    See identical proteins and their annotated locations for NP_001139490.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and lacks an in-frame portion of the 5' coding region, compared to variant 1. The resulting isoform (b) is shorter than isoform a. Variants 3-6, 16, and 17 all encode the same isoform (b).
    Source sequence(s)
    BC064401, DA098538
    Consensus CDS
    CCDS4898.1
    Related
    ENSP00000361521.2, ENST00000372444.6
    Conserved Domains (2) summary
    pfam15453
    Location:274 → 546
    Pilt; Protein incorporated later into Tight Junctions
    cl25732
    Location:17 → 161
    SMC_N; RecF/RecN/SMC N terminal domain

  4. NM_001146019.2 → NP_001139491.1  tight junction-associated protein 1 isoform b

    See identical proteins and their annotated locations for NP_001139491.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks an in-frame exon in the 5' coding region compared to variant 1. The resulting isoform (b) is shorter than isoform a. Variants 3-6, 16 and 17 all encode the same isoform (b).
    Source sequence(s)
    AK074241, AK225787
    Consensus CDS
    CCDS4898.1
    Conserved Domains (2) summary
    pfam15453
    Location:274 → 546
    Pilt; Protein incorporated later into Tight Junctions
    cl25732
    Location:17 → 161
    SMC_N; RecF/RecN/SMC N terminal domain

  5. NM_001146020.2 → NP_001139492.1  tight junction-associated protein 1 isoform b

    See identical proteins and their annotated locations for NP_001139492.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and lacks an in-frame portion of the 5' coding region, compared to variant 1. The resulting isoform (b) is shorter than isoform a. Variants 3-6, 16, and 17 all encode the same isoform (b).
    Source sequence(s)
    AK074241, DA051961
    Consensus CDS
    CCDS4898.1
    Related
    ENSP00000407080.2, ENST00000436109.6
    Conserved Domains (2) summary
    pfam15453
    Location:274 → 546
    Pilt; Protein incorporated later into Tight Junctions
    cl25732
    Location:17 → 161
    SMC_N; RecF/RecN/SMC N terminal domain

  6. NM_001350561.2 → NP_001337490.1  tight junction-associated protein 1 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8), as well as variants 1, 2, and 9-15, encodes isoform a.
    Source sequence(s)
    AL355802, AL359813
    Consensus CDS
    CCDS55004.1
    UniProtKB/Swiss-Prot
    Q05BH9, Q5JTD0, Q5JTD1, Q5JWW1, Q68DB2, Q6P2P3, Q9H7V7
    Conserved Domains (2) summary
    COG1196
    Location:17 → 163
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam15453
    Location:284 → 556
    Pilt; Protein incorporated later into Tight Junctions

  7. NM_001350562.2 → NP_001337491.1  tight junction-associated protein 1 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9), as well as variants 1, 2, 8, and 10-15, encodes isoform a.
    Source sequence(s)
    AL355802, AL359813
    Consensus CDS
    CCDS55004.1
    UniProtKB/Swiss-Prot
    Q05BH9, Q5JTD0, Q5JTD1, Q5JWW1, Q68DB2, Q6P2P3, Q9H7V7
    Related
    ENSP00000361527.1, ENST00000372449.6
    Conserved Domains (2) summary
    COG1196
    Location:17 → 163
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam15453
    Location:284 → 556
    Pilt; Protein incorporated later into Tight Junctions

  8. NM_001350563.2 → NP_001337492.1  tight junction-associated protein 1 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10), as well as variants 1, 2, 8, 9, and 11-15, encodes isoform a.
    Source sequence(s)
    AL355802, AL359813
    Consensus CDS
    CCDS55004.1
    UniProtKB/Swiss-Prot
    Q05BH9, Q5JTD0, Q5JTD1, Q5JWW1, Q68DB2, Q6P2P3, Q9H7V7
    Conserved Domains (2) summary
    COG1196
    Location:17 → 163
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam15453
    Location:284 → 556
    Pilt; Protein incorporated later into Tight Junctions

  9. NM_001350564.2 → NP_001337493.1  tight junction-associated protein 1 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11), as well as variants 1, 2, 8-10, and 12-15, encodes isoform a.
    Source sequence(s)
    AL355802, AL359813
    Consensus CDS
    CCDS55004.1
    UniProtKB/Swiss-Prot
    Q05BH9, Q5JTD0, Q5JTD1, Q5JWW1, Q68DB2, Q6P2P3, Q9H7V7
    Conserved Domains (2) summary
    COG1196
    Location:17 → 163
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam15453
    Location:284 → 556
    Pilt; Protein incorporated later into Tight Junctions

  10. NM_001350565.2 → NP_001337494.1  tight junction-associated protein 1 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12), as well as variants 1, 2, 8-11, and 13-15, encodes isoform a.
    Source sequence(s)
    AL355802
    Consensus CDS
    CCDS55004.1
    UniProtKB/Swiss-Prot
    Q05BH9, Q5JTD0, Q5JTD1, Q5JWW1, Q68DB2, Q6P2P3, Q9H7V7
    Conserved Domains (2) summary
    COG1196
    Location:17 → 163
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam15453
    Location:284 → 556
    Pilt; Protein incorporated later into Tight Junctions

  11. NM_001350566.2 → NP_001337495.1  tight junction-associated protein 1 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (13), as well as variants 1, 2, 8-12, 14, and 15, encodes isoform a.
    Source sequence(s)
    AL355802
    Consensus CDS
    CCDS55004.1
    UniProtKB/Swiss-Prot
    Q05BH9, Q5JTD0, Q5JTD1, Q5JWW1, Q68DB2, Q6P2P3, Q9H7V7
    Conserved Domains (2) summary
    COG1196
    Location:17 → 163
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam15453
    Location:284 → 556
    Pilt; Protein incorporated later into Tight Junctions

  12. NM_001350567.2 → NP_001337496.1  tight junction-associated protein 1 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (14), as well as variants 1, 2, 8-13, and 15, encodes isoform a.
    Source sequence(s)
    AL355802
    Consensus CDS
    CCDS55004.1
    UniProtKB/Swiss-Prot
    Q05BH9, Q5JTD0, Q5JTD1, Q5JWW1, Q68DB2, Q6P2P3, Q9H7V7
    Conserved Domains (2) summary
    COG1196
    Location:17 → 163
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam15453
    Location:284 → 556
    Pilt; Protein incorporated later into Tight Junctions

  13. NM_001350568.2 → NP_001337497.1  tight junction-associated protein 1 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (15), as well as variants 1, 2, and 8-14, encodes isoform a.
    Source sequence(s)
    AL355802
    Consensus CDS
    CCDS55004.1
    UniProtKB/Swiss-Prot
    Q05BH9, Q5JTD0, Q5JTD1, Q5JWW1, Q68DB2, Q6P2P3, Q9H7V7
    Conserved Domains (2) summary
    COG1196
    Location:17 → 163
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam15453
    Location:284 → 556
    Pilt; Protein incorporated later into Tight Junctions

  14. NM_001350569.2 → NP_001337498.1  tight junction-associated protein 1 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (16), as well as variants 3-6 and 17, encodes isoform b.
    Source sequence(s)
    AL355802, AL359813
    Consensus CDS
    CCDS4898.1
    Related
    ENSP00000361530.1, ENST00000372452.5
    Conserved Domains (2) summary
    pfam15453
    Location:274 → 546
    Pilt; Protein incorporated later into Tight Junctions
    cl25732
    Location:17 → 161
    SMC_N; RecF/RecN/SMC N terminal domain

  15. NM_001350570.2 → NP_001337499.1  tight junction-associated protein 1 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (17), as well as variants 3-6 and 16, encodes isoform b.
    Source sequence(s)
    AL355802, AL359813
    Consensus CDS
    CCDS4898.1
    Conserved Domains (2) summary
    pfam15453
    Location:274 → 546
    Pilt; Protein incorporated later into Tight Junctions
    cl25732
    Location:17 → 161
    SMC_N; RecF/RecN/SMC N terminal domain

  16. NM_001394538.1 → NP_001381467.1  tight junction-associated protein 1 isoform c

    Status: REVIEWED

    Source sequence(s)
    AL355802, AL359813
    UniProtKB/TrEMBL
    B3KT40
    Conserved Domains (2) summary
    TIGR02168
    Location:4 → 137
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam15453
    Location:243 → 515
    Pilt; Protein incorporated later into Tight Junctions

  17. NM_001394539.1 → NP_001381468.1  tight junction-associated protein 1 isoform c

    Status: REVIEWED

    Source sequence(s)
    AL355802, AL359813
    UniProtKB/TrEMBL
    B3KT40
    Conserved Domains (2) summary
    TIGR02168
    Location:4 → 137
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam15453
    Location:243 → 515
    Pilt; Protein incorporated later into Tight Junctions

  18. NM_001394540.1 → NP_001381469.1  tight junction-associated protein 1 isoform d

    Status: REVIEWED

    Source sequence(s)
    AL355802, AL359813
    UniProtKB/TrEMBL
    B3KT40
    Conserved Domains (2) summary
    COG1196
    Location:4 → 112
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam15453
    Location:233 → 505
    Pilt; Protein incorporated later into Tight Junctions

  19. NM_001394541.1 → NP_001381470.1  tight junction-associated protein 1 isoform d

    Status: REVIEWED

    Source sequence(s)
    AL355802, AL359813
    UniProtKB/TrEMBL
    B3KT40
    Conserved Domains (2) summary
    COG1196
    Location:4 → 112
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam15453
    Location:233 → 505
    Pilt; Protein incorporated later into Tight Junctions

  20. NM_001394542.1 → NP_001381471.1  tight junction-associated protein 1 isoform d

    Status: REVIEWED

    Source sequence(s)
    AL355802, AL359813
    UniProtKB/TrEMBL
    B3KT40
    Conserved Domains (2) summary
    COG1196
    Location:4 → 112
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam15453
    Location:233 → 505
    Pilt; Protein incorporated later into Tight Junctions

  21. NM_001394543.1 → NP_001381472.1  tight junction-associated protein 1 isoform d

    Status: REVIEWED

    Source sequence(s)
    AL355802, AL359813
    UniProtKB/TrEMBL
    B3KT40
    Conserved Domains (2) summary
    COG1196
    Location:4 → 112
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam15453
    Location:233 → 505
    Pilt; Protein incorporated later into Tight Junctions

  22. NM_001394544.1 → NP_001381473.1  tight junction-associated protein 1 isoform d

    Status: REVIEWED

    Source sequence(s)
    AL355802, AL359813
    UniProtKB/TrEMBL
    B3KT40
    Conserved Domains (2) summary
    COG1196
    Location:4 → 112
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam15453
    Location:233 → 505
    Pilt; Protein incorporated later into Tight Junctions

  23. NM_001394545.1 → NP_001381474.1  tight junction-associated protein 1 isoform d

    Status: REVIEWED

    Source sequence(s)
    AL355802, AL359813
    UniProtKB/TrEMBL
    B3KT40
    Conserved Domains (2) summary
    COG1196
    Location:4 → 112
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam15453
    Location:233 → 505
    Pilt; Protein incorporated later into Tight Junctions

  24. NM_080604.3 → NP_542171.2  tight junction-associated protein 1 isoform b

    See identical proteins and their annotated locations for NP_542171.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and lacks an in-frame portion of the 5' coding region, compared to variant 1. The resulting isoform (b) is shorter than isoform a. Variants 3-6, 16, and 17 all encode the same isoform (b).
    Source sequence(s)
    AK024269, AK074241, DA018836
    Consensus CDS
    CCDS4898.1
    Related
    ENSP00000259751.1, ENST00000259751.5
    Conserved Domains (2) summary
    pfam15453
    Location:274 → 546
    Pilt; Protein incorporated later into Tight Junctions
    cl25732
    Location:17 → 161
    SMC_N; RecF/RecN/SMC N terminal domain

RNA

  1. NR_146793.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL355802, AL359813

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    43477570..43506554
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017011489.2 → XP_016866978.1  tight junction-associated protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q05BH9, Q5JTD0, Q5JTD1, Q5JWW1, Q68DB2, Q6P2P3, Q9H7V7
    Conserved Domains (2) summary
    COG1196
    Location:17 → 163
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam15453
    Location:284 → 556
    Pilt; Protein incorporated later into Tight Junctions

  2. XM_047419532.1 → XP_047275488.1  tight junction-associated protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q05BH9, Q5JTD0, Q5JTD1, Q5JWW1, Q68DB2, Q6P2P3, Q9H7V7

  3. XM_047419534.1 → XP_047275490.1  tight junction-associated protein 1 isoform X2

  4. XM_047419536.1 → XP_047275492.1  tight junction-associated protein 1 isoform X2

  5. XM_047419531.1 → XP_047275487.1  tight junction-associated protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q05BH9, Q5JTD0, Q5JTD1, Q5JWW1, Q68DB2, Q6P2P3, Q9H7V7

  6. XM_047419538.1 → XP_047275494.1  tight junction-associated protein 1 isoform X2

  7. XM_047419529.1 → XP_047275485.1  tight junction-associated protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q05BH9, Q5JTD0, Q5JTD1, Q5JWW1, Q68DB2, Q6P2P3, Q9H7V7

  8. XM_047419530.1 → XP_047275486.1  tight junction-associated protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q05BH9, Q5JTD0, Q5JTD1, Q5JWW1, Q68DB2, Q6P2P3, Q9H7V7

  9. XM_024446586.2 → XP_024302354.1  tight junction-associated protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q05BH9, Q5JTD0, Q5JTD1, Q5JWW1, Q68DB2, Q6P2P3, Q9H7V7
    Conserved Domains (2) summary
    COG1196
    Location:17 → 163
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam15453
    Location:284 → 556
    Pilt; Protein incorporated later into Tight Junctions

  10. XM_047419542.1 → XP_047275498.1  tight junction-associated protein 1 isoform X2

  11. XM_024446584.2 → XP_024302352.1  tight junction-associated protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q05BH9, Q5JTD0, Q5JTD1, Q5JWW1, Q68DB2, Q6P2P3, Q9H7V7
    Conserved Domains (2) summary
    COG1196
    Location:17 → 163
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam15453
    Location:284 → 556
    Pilt; Protein incorporated later into Tight Junctions

  12. XM_017011492.2 → XP_016866981.1  tight junction-associated protein 1 isoform X2

    Conserved Domains (2) summary
    pfam15453
    Location:274 → 546
    Pilt; Protein incorporated later into Tight Junctions
    cl25732
    Location:17 → 161
    SMC_N; RecF/RecN/SMC N terminal domain

  13. XM_024446585.2 → XP_024302353.1  tight junction-associated protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q05BH9, Q5JTD0, Q5JTD1, Q5JWW1, Q68DB2, Q6P2P3, Q9H7V7
    Conserved Domains (2) summary
    COG1196
    Location:17 → 163
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam15453
    Location:284 → 556
    Pilt; Protein incorporated later into Tight Junctions

  14. XM_017011493.2 → XP_016866982.1  tight junction-associated protein 1 isoform X2

    Conserved Domains (2) summary
    pfam15453
    Location:274 → 546
    Pilt; Protein incorporated later into Tight Junctions
    cl25732
    Location:17 → 161
    SMC_N; RecF/RecN/SMC N terminal domain

  15. XM_047419540.1 → XP_047275496.1  tight junction-associated protein 1 isoform X2

  16. XM_006715250.5 → XP_006715313.1  tight junction-associated protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006715313.1

    UniProtKB/Swiss-Prot
    Q05BH9, Q5JTD0, Q5JTD1, Q5JWW1, Q68DB2, Q6P2P3, Q9H7V7
    Conserved Domains (2) summary
    COG1196
    Location:17 → 163
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam15453
    Location:284 → 556
    Pilt; Protein incorporated later into Tight Junctions

  17. XM_011514995.2 → XP_011513297.1  tight junction-associated protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011513297.1

    UniProtKB/Swiss-Prot
    Q05BH9, Q5JTD0, Q5JTD1, Q5JWW1, Q68DB2, Q6P2P3, Q9H7V7
    Conserved Domains (2) summary
    COG1196
    Location:17 → 163
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam15453
    Location:284 → 556
    Pilt; Protein incorporated later into Tight Junctions

  18. XM_047419533.1 → XP_047275489.1  tight junction-associated protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q05BH9, Q5JTD0, Q5JTD1, Q5JWW1, Q68DB2, Q6P2P3, Q9H7V7

  19. XM_024446587.2 → XP_024302355.1  tight junction-associated protein 1 isoform X2

    Conserved Domains (2) summary
    pfam15453
    Location:274 → 546
    Pilt; Protein incorporated later into Tight Junctions
    cl25732
    Location:17 → 161
    SMC_N; RecF/RecN/SMC N terminal domain

  20. XM_047419537.1 → XP_047275493.1  tight junction-associated protein 1 isoform X2

  21. XM_006715251.4 → XP_006715314.1  tight junction-associated protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006715314.1

    UniProtKB/Swiss-Prot
    Q05BH9, Q5JTD0, Q5JTD1, Q5JWW1, Q68DB2, Q6P2P3, Q9H7V7
    Conserved Domains (2) summary
    COG1196
    Location:17 → 163
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam15453
    Location:284 → 556
    Pilt; Protein incorporated later into Tight Junctions

  22. XM_047419541.1 → XP_047275497.1  tight junction-associated protein 1 isoform X2

  23. XM_047419544.1 → XP_047275500.1  tight junction-associated protein 1 isoform X2

  24. XM_006715257.3 → XP_006715320.1  tight junction-associated protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006715320.1

    UniProtKB/Swiss-Prot
    Q05BH9, Q5JTD0, Q5JTD1, Q5JWW1, Q68DB2, Q6P2P3, Q9H7V7
    Conserved Domains (2) summary
    COG1196
    Location:17 → 163
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam15453
    Location:284 → 556
    Pilt; Protein incorporated later into Tight Junctions

  25. XM_047419543.1 → XP_047275499.1  tight junction-associated protein 1 isoform X2

  26. XM_006715254.5 → XP_006715317.1  tight junction-associated protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006715317.1

    UniProtKB/Swiss-Prot
    Q05BH9, Q5JTD0, Q5JTD1, Q5JWW1, Q68DB2, Q6P2P3, Q9H7V7
    Conserved Domains (2) summary
    COG1196
    Location:17 → 163
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam15453
    Location:284 → 556
    Pilt; Protein incorporated later into Tight Junctions

  27. XM_047419535.1 → XP_047275491.1  tight junction-associated protein 1 isoform X2

  28. XM_006715265.2 → XP_006715328.1  tight junction-associated protein 1 isoform X2

    See identical proteins and their annotated locations for XP_006715328.1

    Conserved Domains (2) summary
    pfam15453
    Location:274 → 546
    Pilt; Protein incorporated later into Tight Junctions
    cl25732
    Location:17 → 161
    SMC_N; RecF/RecN/SMC N terminal domain

  29. XM_006715263.3 → XP_006715326.1  tight junction-associated protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006715326.1

    UniProtKB/Swiss-Prot
    Q05BH9, Q5JTD0, Q5JTD1, Q5JWW1, Q68DB2, Q6P2P3, Q9H7V7
    Conserved Domains (2) summary
    COG1196
    Location:17 → 163
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam15453
    Location:284 → 556
    Pilt; Protein incorporated later into Tight Junctions

  30. XM_047419545.1 → XP_047275501.1  tight junction-associated protein 1 isoform X2

  31. XM_006715266.2 → XP_006715329.1  tight junction-associated protein 1 isoform X2

    See identical proteins and their annotated locations for XP_006715329.1

    Conserved Domains (2) summary
    pfam15453
    Location:274 → 546
    Pilt; Protein incorporated later into Tight Junctions
    cl25732
    Location:17 → 161
    SMC_N; RecF/RecN/SMC N terminal domain

  32. XM_006715261.2 → XP_006715324.1  tight junction-associated protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006715324.1

    UniProtKB/Swiss-Prot
    Q05BH9, Q5JTD0, Q5JTD1, Q5JWW1, Q68DB2, Q6P2P3, Q9H7V7
    Conserved Domains (2) summary
    COG1196
    Location:17 → 163
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam15453
    Location:284 → 556
    Pilt; Protein incorporated later into Tight Junctions

  33. XM_047419547.1 → XP_047275503.1  tight junction-associated protein 1 isoform X4

  34. XM_047419548.1 → XP_047275504.1  tight junction-associated protein 1 isoform X4

  35. XM_047419546.1 → XP_047275502.1  tight junction-associated protein 1 isoform X3

    Related
    ENSP00000390981.2, ENST00000442878.6

  36. XM_006715262.3 → XP_006715325.1  tight junction-associated protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006715325.1

    UniProtKB/Swiss-Prot
    Q05BH9, Q5JTD0, Q5JTD1, Q5JWW1, Q68DB2, Q6P2P3, Q9H7V7
    Conserved Domains (2) summary
    COG1196
    Location:17 → 163
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam15453
    Location:284 → 556
    Pilt; Protein incorporated later into Tight Junctions

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    43306318..43335293
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054356772.1 → XP_054212747.1  tight junction-associated protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q05BH9, Q5JTD0, Q5JTD1, Q5JWW1, Q68DB2, Q6P2P3, Q9H7V7

  2. XM_054356768.1 → XP_054212743.1  tight junction-associated protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q05BH9, Q5JTD0, Q5JTD1, Q5JWW1, Q68DB2, Q6P2P3, Q9H7V7

  3. XM_054356774.1 → XP_054212749.1  tight junction-associated protein 1 isoform X2

  4. XM_054356779.1 → XP_054212754.1  tight junction-associated protein 1 isoform X2

  5. XM_054356767.1 → XP_054212742.1  tight junction-associated protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q05BH9, Q5JTD0, Q5JTD1, Q5JWW1, Q68DB2, Q6P2P3, Q9H7V7

  6. XM_054356781.1 → XP_054212756.1  tight junction-associated protein 1 isoform X2

  7. XM_054356763.1 → XP_054212738.1  tight junction-associated protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q05BH9, Q5JTD0, Q5JTD1, Q5JWW1, Q68DB2, Q6P2P3, Q9H7V7

  8. XM_054356765.1 → XP_054212740.1  tight junction-associated protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q05BH9, Q5JTD0, Q5JTD1, Q5JWW1, Q68DB2, Q6P2P3, Q9H7V7

  9. XM_054356762.1 → XP_054212737.1  tight junction-associated protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q05BH9, Q5JTD0, Q5JTD1, Q5JWW1, Q68DB2, Q6P2P3, Q9H7V7

  10. XM_054356786.1 → XP_054212761.1  tight junction-associated protein 1 isoform X2

  11. XM_054356758.1 → XP_054212733.1  tight junction-associated protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q05BH9, Q5JTD0, Q5JTD1, Q5JWW1, Q68DB2, Q6P2P3, Q9H7V7

  12. XM_054356777.1 → XP_054212752.1  tight junction-associated protein 1 isoform X2

  13. XM_054356769.1 → XP_054212744.1  tight junction-associated protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q05BH9, Q5JTD0, Q5JTD1, Q5JWW1, Q68DB2, Q6P2P3, Q9H7V7

  14. XM_054356778.1 → XP_054212753.1  tight junction-associated protein 1 isoform X2

  15. XM_054356783.1 → XP_054212758.1  tight junction-associated protein 1 isoform X2

  16. XM_054356764.1 → XP_054212739.1  tight junction-associated protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q05BH9, Q5JTD0, Q5JTD1, Q5JWW1, Q68DB2, Q6P2P3, Q9H7V7

  17. XM_054356757.1 → XP_054212732.1  tight junction-associated protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q05BH9, Q5JTD0, Q5JTD1, Q5JWW1, Q68DB2, Q6P2P3, Q9H7V7

  18. XM_054356770.1 → XP_054212745.1  tight junction-associated protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q05BH9, Q5JTD0, Q5JTD1, Q5JWW1, Q68DB2, Q6P2P3, Q9H7V7

  19. XM_054356775.1 → XP_054212750.1  tight junction-associated protein 1 isoform X2

  20. XM_054356780.1 → XP_054212755.1  tight junction-associated protein 1 isoform X2

  21. XM_054356759.1 → XP_054212734.1  tight junction-associated protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q05BH9, Q5JTD0, Q5JTD1, Q5JWW1, Q68DB2, Q6P2P3, Q9H7V7

  22. XM_054356784.1 → XP_054212759.1  tight junction-associated protein 1 isoform X2

  23. XM_054356788.1 → XP_054212763.1  tight junction-associated protein 1 isoform X2

  24. XM_054356766.1 → XP_054212741.1  tight junction-associated protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q05BH9, Q5JTD0, Q5JTD1, Q5JWW1, Q68DB2, Q6P2P3, Q9H7V7

  25. XM_054356787.1 → XP_054212762.1  tight junction-associated protein 1 isoform X2

  26. XM_054356761.1 → XP_054212736.1  tight junction-associated protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q05BH9, Q5JTD0, Q5JTD1, Q5JWW1, Q68DB2, Q6P2P3, Q9H7V7

  27. XM_054356776.1 → XP_054212751.1  tight junction-associated protein 1 isoform X2

  28. XM_054356782.1 → XP_054212757.1  tight junction-associated protein 1 isoform X2

  29. XM_054356771.1 → XP_054212746.1  tight junction-associated protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q05BH9, Q5JTD0, Q5JTD1, Q5JWW1, Q68DB2, Q6P2P3, Q9H7V7

  30. XM_054356789.1 → XP_054212764.1  tight junction-associated protein 1 isoform X2

  31. XM_054356785.1 → XP_054212760.1  tight junction-associated protein 1 isoform X2

  32. XM_054356760.1 → XP_054212735.1  tight junction-associated protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q05BH9, Q5JTD0, Q5JTD1, Q5JWW1, Q68DB2, Q6P2P3, Q9H7V7

  33. XM_054356791.1 → XP_054212766.1  tight junction-associated protein 1 isoform X4

  34. XM_054356792.1 → XP_054212767.1  tight junction-associated protein 1 isoform X4

  35. XM_054356790.1 → XP_054212765.1  tight junction-associated protein 1 isoform X3

  36. XM_054356773.1 → XP_054212748.1  tight junction-associated protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q05BH9, Q5JTD0, Q5JTD1, Q5JWW1, Q68DB2, Q6P2P3, Q9H7V7
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5JTD0.1 GenPept UniProtKB/Swiss-Prot:Q5JTD0

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