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spxA redox-sensitive regulator [ Bacillus subtilis subsp. subtilis str. 168 ]

Gene ID: 936407, updated on 12-Feb-2021

Summary

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Gene symbol
spxA
Gene description
redox-sensitive regulator
Locus tag
BSU_11500
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bacillus subtilis subsp. subtilis str. 168 (strain: 168, sub-species: subtilis, type-material: type strain of Bacillus subtilis)
Lineage
Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus
Old locus tag
BSU11500
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Genomic context

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Sequence:
NC_000964.3 (1227697..1228092)

NC_000964.3Genomic Context describing neighboring genes Neighboring gene putative exporter Neighboring gene putative thiol oxidation management factor; putative acetyltransferase Neighboring gene putative membrane protein of unknown function Neighboring gene hypothetical protein Neighboring gene adaptor protein controlling oligomerization of the AAA+ protein ClpC

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000964.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Spx, the central regulator of the heat and oxidative stress response in B. subtilis, can repress transcription of translation-related genes. Schäfer H, et al. Mol Microbiol, 2019 Feb. PMID 30480837
  2. Geobacillus thermodenitrificans YjbH recognizes the C-terminal end of Bacillus subtilis Spx to accelerate Spx proteolysis by ClpXP. Chan CM, et al. Microbiology (Reading), 2012 May. PMID 22343351, Free PMC Article
  3. Spx mediates oxidative stress regulation of the methionine sulfoxide reductases operon in Bacillus subtilis. You C, et al. BMC Microbiol, 2008 Jul 28. PMID 18662407, Free PMC Article
  4. Genome-wide identification of genes directly regulated by the pleiotropic transcription factor Spx in Bacillus subtilis. Rochat T, et al. Nucleic Acids Res, 2012 Oct. PMID 22904090, Free PMC Article
  5. Bacillus subtilis, the model Gram-positive bacterium: 20 years of annotation refinement. Borriss R, et al. Microb Biotechnol, 2018 Jan. PMID 29280348, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Here, the authors show that Spx is a central player orchestrating the heat shock response by up-regulating relevant stress response genes as revealed by comparative transcriptomic experiments. Moreover, these experiments revealed the potential of Spx to inhibit transcription of translation-related genes.
    Title: Spx, the central regulator of the heat and oxidative stress response in B. subtilis, can repress transcription of translation-related genes.
  2. Identification of 283 discrete chromosomal sites potentially bound by the Spx-RNA polymerase (Spx-RNAP) complex using chromatin immunoprecipitation of Spx.
    Title: Genome-wide identification of genes directly regulated by the pleiotropic transcription factor Spx in Bacillus subtilis.
  3. GtYjbH enhances ClpXP-catalysed proteolysis of Spx. The C terminus of Spx is required for YjbH binding.
    Title: Geobacillus thermodenitrificans YjbH recognizes the C-terminal end of Bacillus subtilis Spx to accelerate Spx proteolysis by ClpXP.
  4. Oxidative stress induced the expression of msrAB partially through an oxidation on Spx via modification of its CXXC motif.
    Title: Spx mediates oxidative stress regulation of the methionine sulfoxide reductases operon in Bacillus subtilis.
Submit: New GeneRIF Correction

General gene information

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Homology

General protein information

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Preferred Names
redox-sensitive regulator
NP_389032.1
  • Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12642660, 14597697, 15659166, 16249335, 16740936, 18662407, 22307755, 23894131, 28484046, 22720735; Product type r: regulator

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000964.3 Reference assembly

    Range
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_389032.1 redox-sensitive regulator [Bacillus subtilis subsp. subtilis str. 168]

    See identical proteins and their annotated locations for NP_389032.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    O31602
    Conserved Domains (1) summary
    PRK01655
    Location:1 → 131
    spxA; transcriptional regulator Spx; Reviewed
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O31602.1

Gene LinkOut

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Other Literature Sources
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Research Materials