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sigM RNA polymerase ECF (extracytoplasmic function)-type sigma factor (sigma(M)) [ Bacillus subtilis subsp. subtilis str. 168 ]

Gene ID: 936267, updated on 12-Feb-2021

Summary

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Gene symbol
sigM
Gene description
RNA polymerase ECF (extracytoplasmic function)-type sigma factor (sigma(M))
Locus tag
BSU_09520
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bacillus subtilis subsp. subtilis str. 168 (strain: 168, sub-species: subtilis, type-material: type strain of Bacillus subtilis)
Lineage
Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus
Old locus tag
BSU09520
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Genomic context

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Sequence:
NC_000964.3 (1029577..1030068, complement)

NC_000964.3Genomic Context describing neighboring genes Neighboring gene putative acetyltransferase Neighboring gene negative regulator of the activity of sigma-M Neighboring gene negative regulator of the activity of sigma-M Neighboring gene aldo/keto reductase specific for NADPH; protects against methylglyoxal Neighboring gene 1-acylglycerol-phosphate (1-acyl-G3P) acyltransferase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000964.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Deciphering the essentiality and function of the anti-σ(M) factors in Bacillus subtilis. Zhao H, et al. Mol Microbiol, 2019 Aug. PMID 30715747, Free PMC Article
  2. Modulation of extracytoplasmic function (ECF) sigma factor promoter selectivity by spacer region sequence. Gaballa A, et al. Nucleic Acids Res, 2018 Jan 9. PMID 29069433, Free PMC Article
  3. Induction of extracytoplasmic function sigma factors in Bacillus subtilis cells with defects in lipoteichoic acid synthesis. Hashimoto M, et al. Microbiology (Reading), 2013 Jan. PMID 23103977
  4. Analysis of the role of Bacillus subtilis σ(M) in β-lactam resistance reveals an essential role for c-di-AMP in peptidoglycan homeostasis. Luo Y, et al. Mol Microbiol, 2012 Feb. PMID 22211522, Free PMC Article
  5. Regulatory overlap and functional redundancy among Bacillus subtilis extracytoplasmic function sigma factors. Mascher T, et al. J Bacteriol, 2007 Oct. PMID 17675383, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The activity of SigM is regulated by its anti-sigma factor, YhdL, and the accessory protein YhdK.
    Title: Deciphering the essentiality and function of the anti-σ(M) factors in Bacillus subtilis.
  2. Data show that Bacillus subtilis encodes seven extracytoplasmic function (ECF) sigma (sigma) factors that regulate functions important for survival under conditions eliciting cell envelope stress.
    Title: Modulation of extracytoplasmic function (ECF) sigma factor promoter selectivity by spacer region sequence.
  3. Bacillus subtilis CsbB activates SigM in the absence of co-transcribed YfhO
    Title: A putative bactoprenol glycosyltransferase, CsbB, in Bacillus subtilis activates SigM in the absence of co-transcribed YfhO.
  4. These experiments revealed that sigM and sigX were induced in cells with a null allele of DeltaltaS and DeltayfnI, respectively, and that no extracytoplasmic function sigma factor was induced in cells with a single null allele of DeltayqgS or DeltayvgJ.
    Title: Induction of extracytoplasmic function sigma factors in Bacillus subtilis cells with defects in lipoteichoic acid synthesis.
  5. sigmaM is the major extracytoplasmic function sigma factor involved in the intrinsic resistance to cefuroxime.
    Title: Analysis of the role of Bacillus subtilis σ(M) in β-lactam resistance reveals an essential role for c-di-AMP in peptidoglycan homeostasis.
  6. sigM is a primary determinant for bacitrcin resistance in Bacillus subtilis.
    Title: Regulatory overlap and functional redundancy among Bacillus subtilis extracytoplasmic function sigma factors.
  7. A Bacillus subtilis sigM null mutant, lacking the extracytoplasmic function sigma(M) protein, was sensitive to paraquat (PQ), a superoxide-generating reagent
    Title: Bacillus subtilis paraquat resistance is directed by sigmaM, an extracytoplasmic function sigma factor, and is conferred by YqjL and BcrC.
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General gene information

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Homology

General protein information

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Preferred Names
RNA polymerase ECF (extracytoplasmic function)-type sigma factor (sigma(M))
NP_388833.1
  • Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14651641, 14769884; Product type r: regulator

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000964.3 Reference assembly

    Range
    1029577..1030068 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_388833.1 RNA polymerase ECF (extracytoplasmic function)-type sigma factor (sigma(M)) [Bacillus subtilis subsp. subtilis str. 168]

    See identical proteins and their annotated locations for NP_388833.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    O07582
    Conserved Domains (1) summary
    PRK09644
    Location:1 → 163
    PRK09644; RNA polymerase sigma factor SigM; Provisional
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O07582.1

Gene LinkOut

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Other Literature Sources
Molecular Biology Databases