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MRFAP1L2 Morf4 family associated protein 1 like 2 [ Homo sapiens (human) ]

Gene ID: 93622, updated on 5-Mar-2024

Summary

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Official Symbol
MRFAP1L2provided by HGNC
Official Full Name
Morf4 family associated protein 1 like 2provided by HGNC
Primary source
HGNC:HGNC:25109
See related
Ensembl:ENSG00000170846
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
UPP
Expression
Ubiquitous expression in brain (RPKM 12.2), ovary (RPKM 8.2) and 24 other tissues See more
Orthologs
all
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Genomic context

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See MRFAP1L2 in Genome Data Viewer
Location:
4p16.1
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (6674075..6676047)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (6648973..6651114)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (6675802..6677774)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124900840 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15234 Neighboring gene long intergenic non-protein coding RNA 2482 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:6674796-6675404 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15235 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:6684859-6685361 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:6685913-6686414 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr4:6690316-6691515 Neighboring gene long intergenic non-protein coding RNA 2481 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:6694289-6694826 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:6695136-6695872 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:6695873-6696608 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:6697811-6698573 Neighboring gene S100 calcium binding protein P

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Interaction between p12CDK2AP1 and a novel unnamed protein product inhibits cell proliferation by regulating the cell cycle. Liu L, et al. Mol Med Rep, 2014 Jan. PMID 24248101
  2. Cross-linking mass spectrometry reveals the structural topology of peripheral NuRD subunits relative to the core complex. Spruijt CG, et al. FEBS J, 2021 May. PMID 33283408, Free PMC Article
  3. Ubiquitin-mediated proteolysis of HuR by heat shock. Abdelmohsen K, et al. EMBO J, 2009 May 6. PMID 19322201, Free PMC Article
  4. RIG-I regulates myeloid differentiation by promoting TRIM25-mediated ISGylation. Wu SF, et al. Proc Natl Acad Sci U S A, 2020 Jun 23. PMID 32513696, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • AC093323.3

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of cell cycle IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
MORF4 family associated protein 1 like 2
Names
MORF4 family-associated protein 1-like protein UPP
putative MORF4 family-associated protein 1-like protein UPP

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_138699.3 → NP_619644.1  MORF4 family associated protein 1 like 2

    Status: VALIDATED

    Source sequence(s)
    AC093323
    UniProtKB/Swiss-Prot
    B2RBV5
    Related
    ENSP00000493540.1, ENST00000635031.2
    Conserved Domains (1) summary
    pfam15155
    Location:1 → 119
    MRFAP1; MORF4 family-associated protein1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    6674075..6676047
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047416419.1 → XP_047272375.1  MORF4 family associated protein 1 like 2 isoform X1

    UniProtKB/Swiss-Prot
    B2RBV5
    Related
    ENSP00000495193.1, ENST00000307533.10

  2. XM_047416420.1 → XP_047272376.1  MORF4 family associated protein 1 like 2 isoform X1

    UniProtKB/Swiss-Prot
    B2RBV5
    Related
    ENSP00000493702.1, ENST00000444232.3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    6648973..6651114
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054351268.1 → XP_054207243.1  MORF4 family associated protein 1 like 2 isoform X1

    UniProtKB/Swiss-Prot
    B2RBV5

  2. XM_054351269.1 → XP_054207244.1  MORF4 family associated protein 1 like 2 isoform X1

    UniProtKB/Swiss-Prot
    B2RBV5
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B2RBV5.1 GenPept UniProtKB/Swiss-Prot:B2RBV5

Gene LinkOut

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Chemical Information
Molecular Biology Databases
Research Materials